Prolonged Sitting on Responses to Short-Term Exercise Training

NCT03352063 | Completed

• 1 other identifier: 2017-07-0074
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

Prolonged sitting has been shown to effect the response to a high fat tolerance test (HFTT) after acute exercise. This study will evaluate the effect of prolonged sitting on response to a HFTT after a short term training period.

Conditions

Atherosclerosis; Metabolic Syndrome

Outcome Measures

Primary Outcomes (1)

• Plasma Triglycerides

  Areas under the curve for triglyceride concentration will be calculated for hourly samples from a 6-hour lipid tolerance test

  6 hours

Secondary Outcomes (2)

• Plasma Insulin

  6 hours

• Plasma glucose

  6 hours

Study Arms (2)

Sitting with Exercise

ACTIVE COMPARATOR

Subjects will complete a short term training protocol while sitting \>11 hours per day. This training will be preceded by a VO2max test to aid in setting the correct intensity for training. Subjects will be asked to complete three high fat tolerance tests. One to establish a baseline, the second to determine the acute effects of training, and a third at the completion of training to determine the cumulative effect of exercise training.

Behavioral: Prolonged sitting with exercise

Walking with exercise

ACTIVE COMPARATOR

Subjects will complete a short term training protocol while sitting \<5 hours per day. This training will be preceded by a VO2max test to aid in setting the correct intensity for training. Subjects will be asked to complete three high fat tolerance tests. One to establish a baseline, the second to determine the acute effects of training, and a third at the completion of training to determine the cumulative effect of exercise training.

Behavioral: Active walking with exercise.

Interventions

Prolonged sitting with exercise BEHAVIORAL

Subjects will commit to sitting more than 11 hours per day and taking less than 5000 steps per day while participating in exercise training.

Sitting with Exercise

Active walking with exercise. BEHAVIORAL

Subjects will commit to sitting less than 5 hours per day and taking more than 10000 steps per day while participating in exercise training.

Walking with exercise

Eligibility Criteria

• Age: 18 Years - 35 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• to 35 years

You may not qualify if:

• cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.)
• respiratory problems
• musculoskeletal problems that prevent prolonged sitting or exercise
• obesity
• susceptibility to fainting
• pregnancy

Sponsors & Collaborators

• University of Texas at Austin: lead

Study Sites (1)

University of Texas at Austin Human Performance Laboratory

Austin, Texas, 78712, United States

Location

Related Publications (1)

• Burton HM, Wolfe AS, Vardarli E, Satiroglu R, Coyle EF. Background Inactivity Blunts Metabolic Adaptations to Intense Short-Term Training. Med Sci Sports Exerc. 2021 Sep 1;53(9):1937-1944. doi: 10.1249/MSS.0000000000002646.

  PMID: 34398061 DERIVED

MeSH Terms

Conditions

Atherosclerosis; Metabolic Syndrome

Interventions

Exercise

Condition Hierarchy (Ancestors)

Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Subjects will be randomly assigned to either the sitting plus exercise or walking plus exercise.

Study Record Dates

• First Submitted: October 9, 2017
• First Posted: November 24, 2017
• Study Start: July 17, 2018
• Primary Completion: April 30, 2020
• Study Completion: May 30, 2020
• Last Updated: September 30, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)