The Effect of Sitting and Moderate Exercise on Plasma Triglyceride Elevation After a Meal

NCT03098446 | Completed

• 1 other identifier: 2016-12-0022
• Study Type: interventional
• Target: 10
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the effect of 4 days of sitting and moderate exercise on plasma triglyceride elevation after a meal.

Conditions

Atherosclerosis; Metabolic Syndrome

Outcome Measures

Primary Outcomes (1)

• Plasma Triglycerides

  Areas under the curve for triglyceride concentration will be calculated for hourly samples from a 6-hour lipid tolerance test

  6-hours

Secondary Outcomes (2)

• Plasma Insulin

  6-hours

• Plasma Glucose

  6-hours

Study Arms (2)

Prolonged sitting with exercise

EXPERIMENTAL

Subjects will be asked to undergo prolonged sitting (\~14-hours/day) for 4 days. On the evening of day 4, they will be asked to run at 65% of VO2max for 1-hour.

Behavioral: Prolonged sitting with exercise

Prolonged sitting without exercise

EXPERIMENTAL

Subjects will be asked to undergo prolonged sitting (\~14-hours/day) for 4 days. Subjects will not be asked to complete the acute bout of exercise to serve as a control.

Behavioral: Prolonged sitting without exercise

Interventions

Prolonged sitting with exercise BEHAVIORAL

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo the prolonged sitting trial with the acute bout of exercise on day 4. Day 5 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Prolonged sitting with exercise

Prolonged sitting without exercise BEHAVIORAL

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trial. Following this 2-day period, they will undergo the prolonged sitting trial, but will not be asked to complete an acute bout of exercise on day 4. Day 5 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Prolonged sitting without exercise

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may not qualify if:

• cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.)
• respiratory problems
• musculoskeletal problems that prevent prolonged sitting or exercise
• obesity
• susceptibility to fainting

Sponsors & Collaborators

• University of Texas at Austin: lead

Study Sites (1)

University of Texas at Austin Human Performance Laboratory

Austin, Texas, 78712, United States

Location

MeSH Terms

Conditions

Atherosclerosis; Metabolic Syndrome

Interventions

Exercise

Condition Hierarchy (Ancestors)

Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Subjects will be randomly assigned to either the sitting plus exercise or the sitting without exercise group and then, after a one week washout period, complete the other task.

Study Record Dates

• First Submitted: March 27, 2017
• First Posted: March 31, 2017
• Study Start: April 8, 2017
• Primary Completion: August 11, 2017
• Study Completion: August 11, 2017
• Last Updated: October 5, 2018

Record last verified: 2018-10

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)