Correlation Between Various Adipokines and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG) (18FDG-PET)

NCT01150006 | Completed DMC

• 1 other identifier: PET_Adipokines
• Study Type: observational
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

The inflammatory state and composition of atherosclerotic plaques are considered the main contributing factors responsible for acute cardiovascular events, rather than the degree of stenosis. Recently, positron emission tomography (PET) with 18F-fluoro-deoxyglucose (FDG) has been suggested as a promising novel imaging technique to identify the inflammatory state of atherosclerotic plaque. Recently, a few clinical studies showed that circulating A-FABP level had a close relation with the development of atherosclerosis in human. Therefore, in the present study, the investigators examined the relationship between circulating A-FABP and vascular inflammation of carotid arteries measured using FDG-PET in healthy male subjects.

Conditions

Atherosclerosis

Keywords

atherosclerosis; vascular inflammation; adipocyte fatty acid binding protein; adiponectin; leptin; 18FDG-PET

Outcome Measures

Primary Outcomes (1)

• Vascular inflammation in carotid arterial wall, represented as the target-to-background ratio (TBR), using FDG-PET

  12 weeks

Secondary Outcomes (4)

• Circulating serum A-FABP levels

  12 weeks

• Circulating serum leptin levels

  12weeks

• Circulating serum adiponectin levels

  12 weeks

• Carotid intima-media thickness levels measured using ultrasonography

  12 weeks

Study Arms (1)

Healthy male participants

Other: Cross sectional study

Interventions

Cross sectional study OTHER

This is not intervention study. The purpose of the study is to examine the relationship between various adipokine levels and PET imaging at the cross section setting

Healthy male participants

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy male participats who underwent a medical health check in the health promotion center in Korea Guro University

You may qualify if:

• Healthy male volunteers for visiting routine medical check in our clinic

You may not qualify if:

• History of cardiovascular disease (myocardial infarction, unstable angina,stroke, or cardiovascular revascularization)
• Diabetes
• Hypertension
• Malignancy
• Severe renal or hepatic disease
• Subjects taking medications that might affect inflammation such as NSIAD and statin

Sponsors & Collaborators

• Korea University: lead

Study Sites (1)

Hye Jin Yoo

Seoul, 152-703, South Korea

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

whole blood, plasma, serum

MeSH Terms

Conditions

Atherosclerosis

Interventions

Cross-Sectional Studies

Condition Hierarchy (Ancestors)

Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Epidemiologic Studies; Epidemiologic Study Characteristics; Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• Kyung Mook Choi, MD.PhD

  Korea University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER

Study Record Dates

• First Submitted: June 9, 2010
• First Posted: June 24, 2010
• Study Start: April 1, 2010
• Primary Completion: June 1, 2010
• Study Completion: June 1, 2010
• Last Updated: June 29, 2010

Record last verified: 2010-04

Locations

KR (1)