Correlation Between Estimated Glomerular Filtration Rate(eGFR) and Vascular Inflammation Measured by Positron Emission Tomography (PET) With 18F-fluoro-deoxyglucose (FDG)
1 other identifier
observational
360
1 country
1
Brief Summary
Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. Renal insufficiency is close correlation with atherosclerosis and cardiovascular mortality. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between eGFR and vascular inflammation detected by 18F FDG-PET.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Mar 2011
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2011
CompletedFirst Submitted
Initial submission to the registry
March 16, 2015
CompletedFirst Posted
Study publicly available on registry
March 20, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
September 1, 2016
CompletedSeptember 8, 2016
September 1, 2016
5.5 years
March 16, 2015
September 6, 2016
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Correlation between vascular inflammatory status measured by 18F FDG-PET and eGFR by Modification of Diet in Renal Disease(MDRD) formula
at 1 day of taking 18F FDG - PET
Study Arms (3)
eGFR > 90
group whose eGFR is more than 90
60 < eGFR <90
group whose eGFR is between 60 and 90
eGFR < 60
group whose eGFR is less than 60
Interventions
Eligibility Criteria
Participants who took 18FDG- PET in Korea Guro University
You may qualify if:
- absence of prior cancer diagnosis or remission from cancer at the time of PET imaging and throughout the follow-up period;
- \>=30 years of age;
- no prior history of cardiovascular disease ; and
- absence of acute or chronic inflammatory or autoimmune disease (based on documented medical history) or use of chronic anti-inflammatory therapy.
You may not qualify if:
- age \<35 years
- presence of chronic inflammatory disease
- use of anti-inflammatory medications
- presence of active malignant cancer (defined as any radiological or pathological evidence of malignant cancer disease or undergoing chemotherapy or radiation therapy within 1 year before initial PET/CT and throughout the inter-scan duration).
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Korea Universitylead
Study Sites (1)
Department of Internal Medicine, Korea University College of Medicine
Seoul, VD, South Korea
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- RETROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Medical professor
Study Record Dates
First Submitted
March 16, 2015
First Posted
March 20, 2015
Study Start
March 1, 2011
Primary Completion
September 1, 2016
Study Completion
September 1, 2016
Last Updated
September 8, 2016
Record last verified: 2016-09