Progranulin and CTRP3 in Metabolic Syndrome
1 other identifier
observational
127
1 country
1
Brief Summary
Inflammation has been known to be a pivotal pathogenic mechanism of obesity-related disorders such as type 2 diabetes, metabolic syndrome and atherosclerosis. Adipose tissue functions as a major endocrine organ by adipokine mediated modulation of a number of signaling cascades in target tissues, that has pro-inflammatory or anti-inflammatory activities. Progranulin and CTRP3 are recently discovered novel adipokines. Therefore, the investigators tried to clarify the clinical meaning of these two adipokines in the subjects with or without metabolic syndrome
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started May 2012
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2012
CompletedPrimary Completion
Last participant's last visit for primary outcome
August 1, 2012
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2012
CompletedFirst Submitted
Initial submission to the registry
August 14, 2012
CompletedFirst Posted
Study publicly available on registry
August 20, 2012
CompletedAugust 20, 2012
August 1, 2012
3 months
August 14, 2012
August 16, 2012
Conditions
Outcome Measures
Primary Outcomes (2)
Serum concentration of progranulin in the subjects with metabolic syndrome
12week
Serum concentration of CTRP3 in the subjects with metabolic syndrome
12week
Secondary Outcomes (2)
The relationship of serum progranulin levels with cardiovascular risk factors
12 week
The relationship of serum CTRP3 levels with cardiovascular risk factors
12 week
Study Arms (1)
Apparently Helathy Subjects
Eligibility Criteria
The subjects who visited for a routine health check-up at the Health Promotion Center of Korea University Guro Hospital were enrolled using predefined inclusion and exclusion criteria.
You may qualify if:
- \<age\<80
- apparently healthy subjects
You may not qualify if:
- a history of CVD
- diabetes
- stage 2 hypertension
- malignancy
- severe renal or hepatic disease
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Korea Universitylead
Study Sites (1)
Korea University Guro Hospital
Seoul, South Korea
Related Publications (1)
Yoo HJ, Hwang SY, Hong HC, Choi HY, Yang SJ, Choi DS, Baik SH, Bluher M, Youn BS, Choi KM. Implication of progranulin and C1q/TNF-related protein-3 (CTRP3) on inflammation and atherosclerosis in subjects with or without metabolic syndrome. PLoS One. 2013;8(2):e55744. doi: 10.1371/journal.pone.0055744. Epub 2013 Feb 7.
PMID: 23409033DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
August 14, 2012
First Posted
August 20, 2012
Study Start
May 1, 2012
Primary Completion
August 1, 2012
Study Completion
August 1, 2012
Last Updated
August 20, 2012
Record last verified: 2012-08