Comparison of 18F-fluorodeoxyglucose Positron Emission Tomography and Coronary Computed Tomography in Assessing Vascular Inflammation

NCT01100671 | Completed DMC

• 1 other identifier: PET_Coronary CT
• Study Type: observational
• Target: 120
• Locations: 1 country
• Sites: 1

Brief Summary

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.cardiac multidetector-row CT can provide measurements of coronary artery calcium (CAC), the degree of stenosis, and the characteristics of plaque including its potential vulnerability. Therefore, the purpose of the investigators study is to compare the usefulness of 18 FDG-PET and MDCT in assessing the vascular inflammatory status and vulnerability.

Conditions

Atherosclerosis

Keywords

atherosclerosis; vascular inflammation; MDCT; 18FDG-PET

Outcome Measures

Primary Outcomes (1)

• Correlation between vascular inflammatory status measured by 18FDG PET and MDCT

  20weeks

Secondary Outcomes (1)

• Comparison the correlation with inflammatory marker and vascular inflammatory status assessed by 18FDG PET and MDCT

  20 weeks

Study Arms (1)

Healthy patients

Other: Cross section study

Interventions

Cross section study OTHER

This is not intervention study. The purpose of the study is to examine the relationship of vascular inflammation assessed by 18FDG-PET and MDCT at the cross section setting

Healthy patients

Eligibility Criteria

• Age: 20 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Healthy participants who underwent a medical health check in the health promotion center in Korea Guro University

You may qualify if:

• Healthy patients for visiting routine medical check in our clinic

You may not qualify if:

• History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
• Diabetes
• Stage 2 hypertension (resting blood pressure, ≥ 160/100 mmHg)
• Malignancy
• Severe renal or hepatic disease
• Subjects taking medications that might affect inflammation such as NSIAD and statin

Sponsors & Collaborators

• Korea University: lead

Study Sites (1)

Hye Jin Yoo

Seoul, South Korea

Location

Related Publications (1)

• Yoo HJ, Yong HS, Hwang SY, Eo JS, Hong HC, Seo JA, Kim SG, Kim NH, Choi DS, Baik SH, Choi KM. Association of pooled cohort risk scores with vascular inflammation and coronary artery calcification in Korean adults. Metabolism. 2016 Mar;65(3):1-7. doi: 10.1016/j.metabol.2015.10.016. Epub 2015 Oct 22.

  PMID: 26892510 DERIVED

Biospecimen

Retention: SAMPLES WITHOUT DNA

plasam and serum

MeSH Terms

Conditions

Atherosclerosis

Condition Hierarchy (Ancestors)

Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases

Study Officials

• Kyung Mook Choi, MD.PhD

  Korea University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 8, 2010
• First Posted: April 9, 2010
• Study Start: April 1, 2010
• Primary Completion: July 1, 2011
• Study Completion: August 1, 2011
• Last Updated: March 14, 2018

Record last verified: 2018-03

Locations

KR (1)