Effect of Daily Steps on Fat Metabolism

NCT03697382 | Completed

• 1 other identifier: 2018-08-0031
• Study Type: interventional
• Target: 12
• Locations: 1 country
• Sites: 1

Brief Summary

Reduced ambulatory activity has been shown to effect the response to a high fat tolerance test (HFTT) after acute exercise. This study will evaluate the effect of varying levels of daily ambulation on response to a HFTT after an acute aerobic exercise bout.

Conditions

Atherosclerosis; Metabolic Syndrome

Outcome Measures

Primary Outcomes (1)

• 6-Hour Plasma Triglyceride Area Under the Curve

  Areas under the curve for triglyceride concentration will be calculated for hourly samples from a 6-hour lipid tolerance test.

  6-hours

Secondary Outcomes (2)

• 6-Hour Plasma Insulin Area Under the Curve

  6-hours

• 6-Hour Plasma Glucose Area Under the Curve

  6-hours

Study Arms (3)

Very Low Steps

EXPERIMENTAL

Subjects will be asked to undergo reduced daily stepping to a level of 2,500 steps/d for 2 days. On the evening of day 2, they will be asked to run at 65% of VO2max for 1-hour.

Behavioral: Very Low Steps

Low Steps

EXPERIMENTAL

Subjects will be asked to undergo reduced daily stepping to a level of 5,000 steps/d for 2 days. On the evening of day 2, they will be asked to run at 65% of VO2max for 1-hour.

Behavioral: Low Steps

Moderate Steps

EXPERIMENTAL

Subjects will be asked to undergo reduced daily stepping to a level of 7,500 steps/d for 2 days. On the evening of day 2, they will be asked to run at 65% of VO2max for 1-hour.

Behavioral: Moderate Steps

Interventions

Very Low Steps BEHAVIORAL

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trials. Following this 2-day period, they will undergo the Very Low Stepping trial with the acute bout of exercise on day 2. Day 3 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Very Low Steps

Low Steps BEHAVIORAL

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trials. Following this 2-day period, they will undergo the Low Stepping trial with the acute bout of exercise on day 2. Day 3 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Low Steps

Moderate Steps BEHAVIORAL

Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trials. Following this 2-day period, they will undergo the Moderate Stepping trial with the acute bout of exercise on day 2. Day 3 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides.

Moderate Steps

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may not qualify if:

• Cardiovascular problems (e.g. pre-existing heart issues, coronary artery disease, hypertension, etc.)
• Respiratory problems
• Musculoskeletal problems that prevent prolonged sitting or exercise
• Obesity
• Susceptibility to fainting
• Pregnancy

Sponsors & Collaborators

• University of Texas at Austin: lead

Study Sites (1)

University of Texas at Austin Human Performance Laboratory

Austin, Texas, 78712, United States

Location

Related Publications (1)

• Burton HM, Coyle EF. Daily Step Count and Postprandial Fat Metabolism. Med Sci Sports Exerc. 2021 Feb 1;53(2):333-340. doi: 10.1249/MSS.0000000000002486.

  PMID: 33105387 DERIVED

MeSH Terms

Conditions

Atherosclerosis; Metabolic Syndrome

Condition Hierarchy (Ancestors)

Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases; Cardiovascular Diseases; Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Heath Burton, M.S.

  University of Texas at Austin

  PRINCIPAL INVESTIGATOR

• Edward F Coyle, Ph.D.

  University of Texas at Austin

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Subjects will complete three experimental conditions which include 2 days of reduced step count (2,500, 5,000, and 7,500 steps/day) with 1-hour of exercise at 65% VO2max.

Study Record Dates

• First Submitted: September 25, 2018
• First Posted: October 5, 2018
• Study Start: September 29, 2018
• Primary Completion: February 15, 2020
• Study Completion: May 31, 2020
• Last Updated: September 30, 2021

Record last verified: 2021-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)