NCT00862017

Brief Summary

There are receptors to free glutamate in the oral cavity and stomach that may mediate effects of this amino acid on gastrointestinal physiology. The investigators hypothesize that a chronic supplementation of monosodium glutamate (MSG) could modulate gastric emptying and the further metabolism of dietary protein in healthy subjects.

Trial Health

80
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
13

participants targeted

Target at below P25 for not_applicable healthy

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 1, 2008

Completed
12 months until next milestone

First Submitted

Initial submission to the registry

March 13, 2009

Completed
3 days until next milestone

First Posted

Study publicly available on registry

March 16, 2009

Completed
Last Updated

October 6, 2025

Status Verified

October 1, 2025

First QC Date

March 13, 2009

Last Update Submit

October 1, 2025

Conditions

Healthy

Keywords

Physiology

Study Arms (2)

MSG

EXPERIMENTAL

Subjects receive a 6-d supplementation of MSG and are studied on the 7th day in the postprandial period following a standard meal ingestion with 2g MSG

Dietary Supplement: MSg supplementation

Control

PLACEBO COMPARATOR
Dietary Supplement: NaCl supplementation

Interventions

MSg supplementationDIETARY_SUPPLEMENT
MSG
NaCl supplementationDIETARY_SUPPLEMENT
Control

Eligibility Criteria

Age30 Years - 50 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • BMI 23 to 28

You may not qualify if:

  • pregnancy
  • allergy to milk protein
  • gastrointestinal diseases

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Centre de recherche sur volontaires

Bobigny, 93, France

Location

Related Publications (1)

  • Boutry C, Matsumoto H, Airinei G, Benamouzig R, Tome D, Blachier F, Bos C. Monosodium glutamate raises antral distension and plasma amino acid after a standard meal in humans. Am J Physiol Gastrointest Liver Physiol. 2011 Jan;300(1):G137-45. doi: 10.1152/ajpgi.00299.2010. Epub 2010 Oct 28.

    PMID: 21030612DERIVED

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Purpose
BASIC SCIENCE
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 13, 2009

First Posted

March 16, 2009

Study Start

April 1, 2008

Last Updated

October 6, 2025

Record last verified: 2025-10

Locations

FR(1)