Functional Organization of Somatosensory Responses in the Secondary Somatosensitive Area and Insula
3 other identifiers
interventional
25
1 country
1
Brief Summary
The implication of the second somatosensory area (SII) and the insular cortex in the processing of somatosensory inputs is now well established. However the functional anatomy of these areas hidden in the depth of the sylvian scissure remain mostly unknown. The aim of this fMRI study is to determine the functional cartography of SII and insula. The localization of responses to different somatosensory stimuli (slight touch, warm, cold, heat pain and arthrokinesia) applied on the left hand of 25 healthy volunteers, will be compared.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable healthy
Started Oct 2007
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
October 1, 2007
CompletedFirst Submitted
Initial submission to the registry
October 11, 2007
CompletedFirst Posted
Study publicly available on registry
October 12, 2007
CompletedPrimary Completion
Last participant's last visit for primary outcome
April 1, 2008
CompletedStudy Completion
Last participant's last visit for all outcomes
April 1, 2008
CompletedJune 17, 2009
June 1, 2009
6 months
October 11, 2007
June 16, 2009
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Comparison of euclidian distances between the centroids of clusters activations for the different types of stimulations into SII and insula.
one day
Secondary Outcomes (1)
Determine the Talairach coordinates of the centroids of clusters of activations for the different types of somatosensory stimuli into SII and insula
one day
Study Arms (1)
1
OTHERhealthy volunteers
Interventions
Eligibility Criteria
You may qualify if:
- healthy volunteers will be included ranging in age from 18 to 50 years
- contraception needed for women
- right handed
- All the subjects have to give their written informed consent.
You may not qualify if:
- pregnancy
- neurological or psychiatric disease
- drugs taken \<12h before fMRI
- contra-indications to fMRI : pacemaker, clip, metallic device
- Refusing to be informed of the presence of a cerebral abnormality, detected during MRI.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Service de Neurologie - CHU de Saint-Etienne
Saint-Etienne, 42055, France
Related Publications (2)
Mazzola L, Isnard J, Mauguiere F. Somatosensory and pain responses to stimulation of the second somatosensory area (SII) in humans. A comparison with SI and insular responses. Cereb Cortex. 2006 Jul;16(7):960-8. doi: 10.1093/cercor/bhj038. Epub 2005 Sep 21.
PMID: 16177270BACKGROUNDPeyron R, Schneider F, Faillenot I, Convers P, Barral FG, Garcia-Larrea L, Laurent B. An fMRI study of cortical representation of mechanical allodynia in patients with neuropathic pain. Neurology. 2004 Nov 23;63(10):1838-46. doi: 10.1212/01.wnl.0000144177.61125.85.
PMID: 15557499BACKGROUND
Study Officials
- PRINCIPAL INVESTIGATOR
Laure Mazzola, MD
CHU de Saint-Etienne
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NA
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
Study Record Dates
First Submitted
October 11, 2007
First Posted
October 12, 2007
Study Start
October 1, 2007
Primary Completion
April 1, 2008
Study Completion
April 1, 2008
Last Updated
June 17, 2009
Record last verified: 2009-06