NCT00428779

Brief Summary

The main purpose of the present study is to determine the relative contributions of central and peripheral fatigue during an ultra-endurance exercise.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
30

participants targeted

Target at P25-P50 for not_applicable healthy

Timeline
Completed

Started Sep 2007

Shorter than P25 for not_applicable healthy

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 29, 2007

Completed
1 day until next milestone

First Posted

Study publicly available on registry

January 30, 2007

Completed
7 months until next milestone

Study Start

First participant enrolled

September 1, 2007

Completed
3 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2007

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2007

Completed
Last Updated

June 11, 2009

Status Verified

June 1, 2009

Enrollment Period

3 months

First QC Date

January 29, 2007

Last Update Submit

June 10, 2009

Conditions

Healthy

Keywords

Running during 24 hoursVoluntary evoked force on the musclesElectrically evoked force on the musclesEMG activityMuscle biopsysubjects will be recruited among experienced ultra-runners

Outcome Measures

Primary Outcomes (1)

  • -Voluntary and electrically evoked forces on the contracted muscles

    24 hours

Secondary Outcomes (3)

  • Electrically evoked forces on the relaxed muscles and associated EMG activity

    24 hours

  • Blood samples before the exercise

    every 4 hours

  • Muscle biopsy (vastus lateralis)

    before and after the exercise

Study Arms (2)

1

EXPERIMENTAL

patients running during 24 hours without sleep

Procedure: running during 24 hours without sleep

2

PLACEBO COMPARATOR

patients without sleep during 24 hours

Other: no sleeping

Interventions

running during 24 hours without sleepPROCEDURE

patients running during 24 hours without sleep

1
no sleepingOTHER

patients without sleep during 24 hours

2

Eligibility Criteria

Age18 Years - 60 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • The subjects of the experimental group will be recruited among experienced ultra-runners . They all have run at least a 12 hour race or longer.
  • The control group will be recruited among experienced ultra-runners . Age of control group will be age experimental group more or less 2 years.

You may not qualify if:

  • The subjects will not be selected if:
  • they were injured in the 3 months before the experiment
  • they had a tendon or joint pathology that could impair strength measurements.
  • they participate to an other experiment at the same time

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Pr André GEYSSANT

Saint-Etienne, 42055, France

Location

Related Publications (2)

  • Morin JB, Samozino P, Feasson L, Geyssant A, Millet G. Effects of muscular biopsy on the mechanics of running. Eur J Appl Physiol. 2009 Jan;105(2):185-90. doi: 10.1007/s00421-008-0888-2. Epub 2008 Oct 8.

    PMID: 18841378RESULT

  • Jamart C, Francaux M, Millet GY, Deldicque L, Frere D, Feasson L. Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running. J Appl Physiol (1985). 2012 May;112(9):1529-37. doi: 10.1152/japplphysiol.00952.2011. Epub 2012 Feb 16.

    PMID: 22345427DERIVED

MeSH Terms

Interventions

Sleep

Intervention Hierarchy (Ancestors)

Nervous System Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • DENIS Christian, Professor

    Service de médecine du sport, CHU SAINT-ETIENNE

    STUDY CHAIR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
HEALTH SERVICES RESEARCH
Intervention Model
PARALLEL
Sponsor Type
OTHER

Study Record Dates

First Submitted

January 29, 2007

First Posted

January 30, 2007

Study Start

September 1, 2007

Primary Completion

December 1, 2007

Study Completion

December 1, 2007

Last Updated

June 11, 2009

Record last verified: 2009-06

Locations

FR(1)