Influence of Protein Source on Satiety and Metabolism
1 other identifier
interventional
120
1 country
1
Brief Summary
Dietary protein is the more satiating nutrient, however it is not clear whether satiety may be influenced by the nature of the protein. This study was designed to assess potential differences between protein sources on satiety and their relationship with digestive and metabolic kinetics.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable healthy
Started Mar 2008
Longer than P75 for not_applicable healthy
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 1, 2008
CompletedFirst Submitted
Initial submission to the registry
March 13, 2009
CompletedFirst Posted
Study publicly available on registry
March 16, 2009
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2009
CompletedStudy Completion
Last participant's last visit for all outcomes
November 1, 2010
CompletedMarch 22, 2012
March 1, 2012
1.3 years
March 13, 2009
March 21, 2012
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
satiety
7 days
Secondary Outcomes (1)
hormonal profiles, digestive fluxes of nutrients, postprandial dietary N metabolism
9 days
Study Arms (4)
Casein
EXPERIMENTALMSP
EXPERIMENTALCasein/MSP
EXPERIMENTALSoy protein
EXPERIMENTALInterventions
Subjects consume for 9 days a supplement of 30g/d of casein
Subjects consume for 9 days a supplement of 30g/d of milk soluble protein
Subjects consume for 9 days a supplement of 30g/d of a mix of casein and milk soluble protein
Subjects consume for 9 days a supplement of 30g/d of soy protein
Eligibility Criteria
You may qualify if:
- BMI between 25 and 30
You may not qualify if:
- allergy to milk proteins
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Centre de recherche sur volontaires
Bobigny, 93, France
Related Publications (2)
Marsset-Baglieri A, Fromentin G, Airinei G, Pedersen C, Leonil J, Piedcoq J, Remond D, Benamouzig R, Tome D, Gaudichon C. Milk protein fractions moderately extend the duration of satiety compared with carbohydrates independently of their digestive kinetics in overweight subjects. Br J Nutr. 2014 Aug 28;112(4):557-64. doi: 10.1017/S0007114514001470. Epub 2014 Jun 26.
PMID: 24968280DERIVEDBoutrou R, Gaudichon C, Dupont D, Jardin J, Airinei G, Marsset-Baglieri A, Benamouzig R, Tome D, Leonil J. Sequential release of milk protein-derived bioactive peptides in the jejunum in healthy humans. Am J Clin Nutr. 2013 Jun;97(6):1314-23. doi: 10.3945/ajcn.112.055202. Epub 2013 Apr 10.
PMID: 23576048DERIVED
MeSH Terms
Interventions
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- BASIC SCIENCE
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Manager of the HNRC
Study Record Dates
First Submitted
March 13, 2009
First Posted
March 16, 2009
Study Start
March 1, 2008
Primary Completion
June 1, 2009
Study Completion
November 1, 2010
Last Updated
March 22, 2012
Record last verified: 2012-03