Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer

NCT00054327 | Completed Phase 2 Results DMC

• 3 other identifiers: CWRU1Y00P30CA043703CASE-CWRU-1Y00
• Study Type: interventional
• Target: 34
• Locations: 1 country
• Sites: 1

Brief Summary

RATIONALE: Giving chemotherapy and total-body irradiation before a donor peripheral stem cell transplant helps stop the growth of cancer and abnormal cells and helps stop the patient's immune system from rejecting the donor's stem cells. When the stem cells from a related donor, that do not exactly match the patient's blood, are infused into the patient they may help the patient's bone marrow make stem cells, red blood cells, white blood cells, and platelets. PURPOSE: This phase II trial is studying how well giving chemotherapy with or without radiation therapy followed by donor stem cell transplant works in treating patients with hematologic cancer.

Conditions

Leukemia; Lymphoma; Myelodysplastic Syndromes; Myelodysplastic/Myeloproliferative Diseases

Keywords

adult acute myeloid leukemia in remission; childhood acute myeloid leukemia in remission; recurrent adult acute myeloid leukemia; recurrent childhood acute myeloid leukemia; adult acute lymphoblastic leukemia in remission; childhood acute lymphoblastic leukemia in remission; refractory anemia with excess blasts in transformation; refractory anemia with excess blasts; recurrent adult diffuse large cell lymphoma; recurrent adult diffuse mixed cell lymphoma; recurrent adult diffuse small cleaved cell lymphoma; recurrent adult Burkitt lymphoma; recurrent adult immunoblastic large cell lymphoma; recurrent adult lymphoblastic lymphoma; recurrent grade 3 follicular lymphoma; secondary acute myeloid leukemia; accelerated phase chronic myelogenous leukemia; blastic phase chronic myelogenous leukemia; chronic phase chronic myelogenous leukemia; recurrent childhood large cell lymphoma; recurrent childhood lymphoblastic lymphoma; recurrent childhood small noncleaved cell lymphoma; recurrent mantle cell lymphoma; refractory anemia with ringed sideroblasts; refractory anemia; chronic myelomonocytic leukemia; refractory cytopenia with multilineage dysplasia; previously treated myelodysplastic syndromes; de novo myelodysplastic syndromes; secondary myelodysplastic syndromes; relapsing chronic myelogenous leukemia; childhood chronic myelogenous leukemia; atypical chronic myeloid leukemia; myelodysplastic/myeloproliferative disease, unclassifiable; juvenile myelomonocytic leukemia; adult acute myeloid leukemia with t(8;21)(q22;q22); adult acute myeloid leukemia with t(16;16)(p13;q22); adult acute myeloid leukemia with inv(16)(p13;q22); adult acute myeloid leukemia with 11q23 (MLL) abnormalities; adult acute myeloid leukemia with t(15;17)(q22;q12); childhood myelodysplastic syndromes

Outcome Measures

Primary Outcomes (1)

• Rates of Durable Engraftment

  Number of days that patients take to reach engraftment defined as time to hematologic engraftment will be defined as ANC \>500/µl and platelets \>20K/µl without transfusion support.

  at day 42

Secondary Outcomes (3)

• Graft-versus-host Disease (GVHD)

  at 100 days post transplant

• Incidence of Recurrent Disease

  at day 100 post transplant

• Toxicity as Measured by CTC v2.0

  at 100 days post transplant

Study Arms (6)

Regimen A

EXPERIMENTAL

Patients receive cytarabine 3.0gm/M² IV over 1 hour twice daily on days -9 to -7 and cyclophosphamide 45mg/kg IV over 2 hours on days -6 and -5. Patients also undergo total body irradiation (TBI), 165 cGY, twice daily on days -4 to -1 for a total of 1320 cGY.

Drug: cyclophosphamide; Drug: cytarabine; Radiation: radiation therapy; Procedure: Stem Cell Transfusion

Regimen B-1

EXPERIMENTAL

Patients receive cyclophosphamide 60 mg/kg IV on days -6 and -5. Patients also undergo total body irradiation (TBI) twice daily on days -4 to -1 for a total of 1320 cGY..

Drug: cyclophosphamide; Radiation: radiation therapy; Procedure: Stem Cell Transfusion

Regimen B-2

EXPERIMENTAL

Patients receive cyclophosphamide 60 mg/kg IV over 2 hours on days -5 and -4. Patients also undergo TBI twice daily on days -3 to -1 for a total of 1200 cGY.

Drug: cyclophosphamide; Radiation: radiation therapy; Procedure: Stem Cell Transfusion

Regimen C

EXPERIMENTAL

Patients receive oral busulfan 1mg/kg/dose (or 40mg/m2/dose for young children)4 times daily on days -8 to -5 and cyclophosphamide 60 mg/kg IV over 2 hours on days -4 to -2.

Drug: busulfan; Drug: cyclophosphamide; Procedure: Stem Cell Transfusion

Regimen B-3

EXPERIMENTAL

Patients undergo total body irradiation (TBI) twice daily on days -7 to -5 for a total of 1200 cGY. Patients then receive cyclophosphamide 60 mg/kg IV on days -4 and -3.

Drug: cyclophosphamide; Radiation: radiation therapy; Procedure: Stem Cell Transfusion

Regimen D

EXPERIMENTAL

Patients receive total body irradiation (TBI) on days T -6, -5 and -4 for a total of 1320 cGy , then etoposide (60mg/kg/dose) on day -3.

Radiation: radiation therapy; Drug: Etoposide; Procedure: Stem Cell Transfusion

Interventions

busulfan DRUG

Given orally 1mg/kg/dose (or 40mg/m2/dose for young children)

Also known as: Myleran

Regimen C

cyclophosphamide DRUG

Given IV

Also known as: cytoxan, CTX, CPM

Regimen A; Regimen B-1; Regimen B-2; Regimen B-3; Regimen C

cytarabine DRUG

Given IV

Also known as: Cytosine Arabinoside, Cytosar-U, Ara-C, Arabinosyl

Regimen A

radiation therapy RADIATION

Patients undergo total body irradiation

Also known as: Total body irradiation

Regimen A; Regimen B-1; Regimen B-2; Regimen B-3; Regimen D

Etoposide DRUG

infusion

Also known as: VP-16, VePesid®, VP-16-213, EPEG, epipodophyllotoixn

Regimen D

Stem Cell Transfusion PROCEDURE

Regimen A; Regimen B-1; Regimen B-2; Regimen B-3; Regimen C; Regimen D

Eligibility Criteria

• Age: Up to 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)

Eligibility Criteria: 1. Patients with histologic confirmation of the following diseases are eligible: 1. AML in first, second or greater remission 2. AML in early relapse, defined at \<30% marrow blasts 3. ALL in second or greater complete remission 4. High risk ALL in first complete remission, with high risk being defined by the presence of t(4;11), t(9;22), or t(8;14) translocation, or patients presenting with extreme hyperleukocytosis (initial WBC \>500 K/ml) or failure to achieve a complete remission after standard induction therapy. 5. CML 6. Myelodysplastic syndromes (including evolution to AML, e.g., Refractory Anemia with Excess Blasts (RAEB), or Refractory Anemia with Excess Blasts in transformation (RAEB-t). 7. Lymphoma (intermediate and high grade) chemosensitive (CR or PR) after first or greater relapse or chemosensitive to first line therapy but only achieving PR. 8. Hematologic Disease and Inherited Immunodeficiencies 9. Hodgkin's disease, relapsed or refractory to standard treatments. 2. Patients must be less than or equal to 55 years of age. 3. Patients (or guardians if minor) must be able to give informed consent. Children older than 11 years of age must assent to the process. 4. Patients or their guardians must demonstrate proof-of-payment. 5. Patients must have an ECOG Performance Status of 2 or less. (See Appendix I) 6. Patients must have no evidence of active infection at the time of transplantation. 7. Patients must be HIV nonreactive. 8. Patients must have a pre-transplant, multi-organ assessment prior to transplantation with the following outcome: 1. resting ejection fraction of 50% or greater (or shortening fraction greater than 28% for small children). 2. Diffusion capacity of 50% or greater of predicted, a FEV1 of 50% or greater, and a P2O of 80 mm Hg as demonstrated on pulmonary function testing. 3. serum creatinine of less than or equal to 2.0 mg/dL and/or a corrected creatinine clearance of 50 ml/min or greater on 24 hr urine. 4. A total bilirubin of less than 2.5 mg/dL and an AST less than 4 times the upper limits of normal. 9. Females who are childbearing age may not be pregnant or lactating and must have a current negative pregnancy test Ineligibility Criteria: * Patients who have a life expectancy of less than three months with therapy. * Patients who have an ECOG performance status greater than 2, (See Appendix I) or Lansky Scale \< 70%. * Patients who have angina and/or congestive heart failure requiring treatment, or who have had a myocardial infarction within the past year. * Patients who have a resting ejection of less than 50% (or shortening fraction less than 28%) and who have not been cleared for transplant by cardiology * Patients who have severe renal disease as demonstrated by a serum creatinine greater than 2.0 mg/dL and/or a corrected creatinine clearance less than 50 ml/min. (corrected for BSA of 1.73 m¬2) * Patients who have had any complication that makes the risk of death during transplantation from non-malignant causes greater than the risk of relapse. * Patients who have any active infection such as a soft tissue infection, sinus infection, dental infection, fungal infection or hepatitis including chronic active hepatitis; if the infection is successfully treated, the patient may be reconsidered for transplantation at a later date. * Patients who have decreased pulmonary function due to any disorder as demonstrated by a diffusion capacity of less than 50% of predicted, a FEV1 of less than 50% of predicted or a PO2 of less than 80 mm Hg pulmonary function testing. * Patients who have decreased liver function as demonstrated by a total bilirubin of greater than 2.5 mg/dL and/or an AST greater than 4 times the upper limits of normal. * Patients who have diabetes mellitus will be considered on a case-by-case basis. However, patients with diabetes who are not controlled by medical management will be ineligible. -Patients who have a significant psychiatric illness will be considered on a case- by-case basis. With the patient's consent, their Mental Health Care worker will assist the managing transplant physicians in determining if the patient can safely undergo transplantation and comply with followup recommendations. * Psychosocial assessment by the bone marrow transplant team may identify individuals for whom this form of therapy may be contraindicated. This decision will be based upon estimated adequacy of patient support systems and prediction of patient's compliance with medications, required diagnostic procedures and/or follow-up care. * Females who are childbearing age may not be pregnant or lactating and must have a current negative pregnancy test * Patients who had a stem cell transplant less than one year earlier

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• Case Comprehensive Cancer Center: lead
• National Cancer Institute (NCI): collaborator

Study Sites (1)

Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center

Cleveland, Ohio, 44106-5065, United States

Location

MeSH Terms

Conditions

Leukemia; Lymphoma; Myelodysplastic Syndromes; Myelodysplastic-Myeloproliferative Diseases; Leukemia, Myeloid, Acute; Anemia, Refractory, with Excess of Blasts; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Burkitt Lymphoma; Lymphoma, Large-Cell, Immunoblastic; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Lymphoma, Follicular; Leukemia, Myeloid, Accelerated Phase; Blast Crisis; Leukemia, Myeloid, Chronic-Phase; Dendritic Cell Sarcoma, Interdigitating; Lymphoma, Mantle-Cell; Anemia, Refractory; Leukemia, Myelomonocytic, Chronic; Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative; Myeloproliferative Disorders; Leukemia, Myelomonocytic, Juvenile; Congenital Abnormalities

Interventions

Busulfan; Cyclophosphamide; Cytarabine; Radiotherapy; Whole-Body Irradiation; Etoposide

Condition Hierarchy (Ancestors)

Neoplasms by Histologic Type; Neoplasms; Hematologic Diseases; Hemic and Lymphatic Diseases; Lymphoproliferative Disorders; Lymphatic Diseases; Immunoproliferative Disorders; Immune System Diseases; Bone Marrow Diseases; Leukemia, Myeloid; Anemia; Lymphoma, B-Cell; Epstein-Barr Virus Infections; Herpesviridae Infections; DNA Virus Infections; Virus Diseases; Infections; Tumor Virus Infections; Leukemia, Lymphoid; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Cell Transformation, Neoplastic; Carcinogenesis; Neoplastic Processes; Histiocytic Disorders, Malignant; Histiocytosis; Congenital, Hereditary, and Neonatal Diseases and Abnormalities

Intervention Hierarchy (Ancestors)

Butylene Glycols; Glycols; Alcohols; Organic Chemicals; Mesylates; Alkanesulfonates; Alkanesulfonic Acids; Alkanes; Hydrocarbons, Acyclic; Hydrocarbons; Sulfonic Acids; Sulfur Acids; Sulfur Compounds; Phosphoramide Mustards; Nitrogen Mustard Compounds; Mustard Compounds; Hydrocarbons, Halogenated; Phosphoramides; Organophosphorus Compounds; Cytidine; Pyrimidine Nucleosides; Pyrimidines; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Arabinonucleosides; Nucleosides; Nucleic Acids, Nucleotides, and Nucleosides; Therapeutics; Investigative Techniques; Podophyllotoxin; Tetrahydronaphthalenes; Naphthalenes; Polycyclic Aromatic Hydrocarbons; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Polycyclic Compounds; Glucosides; Glycosides; Carbohydrates

Results Point of Contact

• Title: Kenneth Cooke MD
• Organization: Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center

kenneth.cooke@uhhospitals.org

216-844-3345

Study Officials

• Kenneth Cooke, MD

  Case Medical Center, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center

  PRINCIPAL INVESTIGATOR

Publication Agreements

• PI is Sponsor Employee: Yes

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 5, 2003
• First Posted: February 6, 2003
• Study Start: November 1, 2000
• Primary Completion: September 1, 2011
• Study Completion: September 1, 2011
• Last Updated: July 24, 2013
• Results First Posted: July 24, 2013

Record last verified: 2013-06

Locations

US (1)