Key Insights

Highlights

Success Rate

76% trial completion

Published Results

202 trials with published results (20%)

Research Maturity

487 completed trials (49% of total)

Clinical Risk Assessment

Based on trial outcomes

High Risk

Score: 59/100

Termination Rate

15.3%

151 terminated out of 990 trials

Success Rate

76.3%

-10.2% vs benchmark

Late-Stage Pipeline

8%

80 trials in Phase 3/4

Results Transparency

41%

202 of 487 completed with results

Key Signals

202 with results76% success151 terminated

Data Visualizations

Phase Distribution

866Total
Not Applicable (77)
Early P 1 (11)
P 1 (339)
P 2 (359)
P 3 (65)
P 4 (15)

Trial Status

Completed487
Terminated151
Recruiting132
Unknown84
Active Not Recruiting58
Withdrawn50

Trial Success Rate

76.3%

Benchmark: 86.5%

Based on 487 completed trials

Clinical Trials (990)

Showing 20 of 20 trials
NCT03560882Phase 1Active Not Recruiting

A Pilot Trial of Atorvastatin in Tumor Protein 53 (p53) -Mutant and p53 Wild-Type Malignancies

NCT06303193Phase 1RecruitingPrimary

Pacritinib, a Kinase Inhibitor of CSF1R, IRAK1, JAK2, and FLT3, in Adults and Pediatric Participants 12 Years of Age or Older With Myelodysplastic Syndromes or Myelodysplastic/Myeloproliferative Neoplasms

NCT07570056Not Yet RecruitingPrimary

Use of Electrical Bioimpedance in Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) Patients (Bioimpedance)

NCT05732961Phase 2Active Not RecruitingPrimary

Luspatercept for Anemia in Lower Risk MDS or Non-proliferative MDS/MPN Neoplasms

NCT05949684Phase 3Active Not RecruitingPrimary

ELEMENT-MDS: A Study to Compare the Efficacy and Safety of Luspatercept in Participants With Myelodysplastic Syndrome (MDS) and Anemia Not Receiving Blood Transfusions

NCT04888741Phase 2Recruiting

Methods of T Cell Depletion Trial (MoTD)

NCT04477850Phase 2CompletedPrimary

A Study to Evaluate the Efficacy, Drug Levels and Safety of Luspatercept (ACE-536) for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes in Chinese and Japanese Participants With Ring Sideroblasts Who Require Red Blood Cell Transfusions

NCT07566377Phase 2Recruiting

Cord Blood Transplantation in Children and Young Adults With Blood Cancer

NCT00662090RecruitingPrimary

Study for Epidemiology and Characterization of Myelodysplastic Syndromes (MDS) and Juvenile Myelomonocytic Leucemia (JMML) in Childhood

NCT06113302Phase 2RecruitingPrimary

A Pilot, Open-Label Study of Luspatercept for Patients With Lower Risk Myelodysplastic Syndromes (MDS)

NCT04482894Not ApplicableActive Not Recruiting

Palliative Care Oncology in Patients With Relapsed, Refractory, and High-Risk Leukemias or MDS

NCT04167917Phase 1Completed

NTX-301 in MDS/AML

NCT05320198Phase 1Recruiting

Study of DISC-0974 (RALLY-MF) in Participants With Myelofibrosis or Myelodysplastic Syndrome and Anemia

NCT04953910Phase 1Recruiting

Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Hepatic Impairment

NCT07019155Recruiting

Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants

NCT04256317Phase 2RecruitingPrimary

A Multi-phase Study of ASTX030 (Azacitidine and Cedazuridine) in Myeloid Neoplasm Alone or in Combination With Venetoclax in AML (AZTOUND Study)

NCT04953897Phase 1Recruiting

Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Renal Impairment

NCT02211755Phase 1Completed

Trial of the Combination of Bortezomib and Clofarabine in Adults With Relapsed Solid Tumors

NCT05593185Unknown

Expanded Access Program (EAP) for Galinpepimut-S (GPS) in Patients Diagnosed With AML or MDS

NCT05490446Phase 2Active Not RecruitingPrimary

A Study of Tebapivat (AG-946) in Participants With Anemia Due to Lower-Risk Myelodysplastic Syndromes (LR-MDS)

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