Chemotherapy Followed by Surgery and Radiation Therapy With or Without Stem Cell Transplant in Treating Patients With Relapsed or Refractory Wilms' Tumor or Clear Cell Sarcoma of the Kidney
Protocol For The Treatment Of Relapsed And Refractory Wilms Tumour And Clear Cell Sarcoma Of The Kidney (CCSK)
3 other identifiers
interventional
75
2 countries
21
Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplant may allow the doctor to give higher doses of chemotherapy drugs and kill more tumor cells. PURPOSE: This phase II trial is studying how well chemotherapy followed by surgery and radiation therapy with or without stem cell transplant work in treating patients with relapsed or refractory Wilms' tumor or clear cell sarcoma of the kidney.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for phase_2
21 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2001
CompletedFirst Submitted
Initial submission to the registry
October 11, 2001
CompletedFirst Posted
Study publicly available on registry
January 27, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
November 1, 2008
CompletedAugust 2, 2013
June 1, 2009
7.5 years
October 11, 2001
August 1, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
Unified treatment strategy
Improvement of current survival rates
Efficacy and toxicity
Prognostic variables
Interventions
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
Study Sites (21)
Our Lady's Hospital for Sick Children Crumlin
Dublin, 12, Ireland
Birmingham Children's Hospital
Birmingham, England, B4 6NH, United Kingdom
Bristol Royal Hospital for Children
Bristol, England, BS2 8BJ, United Kingdom
Addenbrooke's Hospital
Cambridge, England, CB2 2QQ, United Kingdom
Leeds Cancer Centre at St. James's University Hospital
Leeds, England, LS9 7TF, United Kingdom
Leicester Royal Infirmary
Leicester, England, LE1 5WW, United Kingdom
Royal Liverpool Children's Hospital, Alder Hey
Liverpool, England, L12 2AP, United Kingdom
Saint Bartholomew's Hospital
London, England, EC1A 7BE, United Kingdom
Great Ormond Street Hospital for Children
London, England, WC1N 3JH, United Kingdom
University College of London Hospitals
London, England, WIT 3AA, United Kingdom
Royal Manchester Children's Hospital
Manchester, England, M27 4HA, United Kingdom
Newcastle Upon Tyne Hospitals NHS Trust
Newcastle upon Tyne, England, NE7 7DN, United Kingdom
Queen's Medical Centre
Nottingham, England, NG7 2UH, United Kingdom
Oxford Radcliffe Hospital
Oxford, England, 0X3 9DU, United Kingdom
Children's Hospital - Sheffield
Sheffield, England, S10 2TH, United Kingdom
Southampton General Hospital
Southampton, England, SO16 6YD, United Kingdom
Royal Marsden - Surrey
Sutton, England, SM2 5PT, United Kingdom
Royal Belfast Hospital for Sick Children
Belfast, Northern Ireland, BT12 6BE, United Kingdom
Aberdeen Royal Infirmary
Aberdeen, Scotland, AB25 2ZN, United Kingdom
Royal Hospital for Sick Children
Edinburgh, Scotland, EH9 1LF, United Kingdom
Royal Hospital for Sick Children
Glasgow, Scotland, G3 8SJ, United Kingdom
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Juliet Hale, MD
Newcastle-upon-Tyne Hospitals NHS Trust