S0012 Doxorubicin, Cyclophosphamide, and Paclitaxel With or Without Filgrastim in Treating Women With Inflammatory or Locally Advanced Breast Cancer
A Comparative Randomized Study of Standard Doxorubicin and Cyclophosphamide Followed by Weekly Paclitaxel Vs. Weekly Doxorubicin and Daily Oral Cyclophosphamide Plus G-CSF Followed by Weekly Paclitaxel As Neoadjuvant Therapy For Inflammatory and Locally Advanced Breast Cancer
3 other identifiers
interventional
399
1 country
314
Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known whether combination chemotherapy is more effective with or without filgrastim in treating breast cancer. PURPOSE: Randomized phase III trial to compare the effectiveness of combining doxorubicin, cyclophosphamide, and paclitaxel with or without filgrastim in treating women who have inflammatory or locally advanced breast cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for phase_3 breast-cancer
Started May 2001
Longer than P75 for phase_3 breast-cancer
314 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2001
CompletedFirst Submitted
Initial submission to the registry
May 6, 2001
CompletedFirst Posted
Study publicly available on registry
January 27, 2003
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2006
CompletedStudy Completion
Last participant's last visit for all outcomes
February 1, 2012
CompletedJanuary 24, 2013
January 1, 2013
5.3 years
May 6, 2001
January 23, 2013
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
Comparison of microscopic pathologic response rates
no sooner than 21 days after chemo
Toxicity
during chemo and at surgery
Comparison of delivered dose intensity
after chemo
Correlation of microscopic pathologic complete response with clinical complete response at the primary tumor site
no sooner than 21 days after chemo
Study Arms (2)
AC followed by P
ACTIVE COMPARATORdoxorubicin and cyclophosphamide followed by paclitaxel followed by surgery
AC+G followed by P
EXPERIMENTALweekly doxorubicin and daily cyclophosphamide with filgrastim followed by paclitaxel followed by surgery
Interventions
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
- SWOG Cancer Research Networklead
- National Cancer Institute (NCI)collaborator
Study Sites (314)
Mobile Infirmary Medical Center
Mobile, Alabama, 36607, United States
Alaska Regional Hospital Cancer Center
Anchorage, Alaska, 99508, United States
Fairbanks Cancer Treatment Center at Fairbanks Memorial Hospital
Fairbanks, Alaska, 99701, United States
Mayo Clinic Scottsdale
Scottsdale, Arizona, 85259, United States
Hembree Mercy Cancer Center at St. Edward Mercy Medical Center
Fort Smith, Arkansas, 72903, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
Highlands Oncology Group - Springdale
Springdale, Arkansas, 72764, United States
Glendale Memorial Hospital Comprehensive Cancer Center
Glendale, California, 91204, United States
Saint Rose Hospital
Hayward, California, 94545, United States
Valley Memorial Hospital
Livermore, California, 94550, United States
USC/Norris Comprehensive Cancer Center and Hospital
Los Angeles, California, 90033-0804, United States
Highland General Hospital at St. George's University School of Medicine
Oakland, California, 94602, United States
CCOP - Bay Area Tumor Institute
Oakland, California, 94609, United States
Summit Medical Center
Oakland, California, 94609, United States
Comprehensive Cancer Center at Desert Regional Medical Center
Palm Springs, California, 92262, United States
J.C. Robinson, M.D. Regional Cancer Center
San Pablo, California, 94806, United States
Memorial Hospital Cancer Center
Colorado Springs, Colorado, 80909, United States
Halifax Medical Center
Daytona Beach, Florida, 32115, United States
Michael & Dianne Bienes Comprehensive Cancer Center at Holy Cross Hospital
Fort Lauderdale, Florida, 33308, United States
Memorial Cancer Institute at Memorial Regional Hospital
Hollywood, Florida, 33021, United States
Mayo Clinic - Jacksonville
Jacksonville, Florida, 32224-9980, United States
Ella Milbank Foshay Cancer Center at Jupiter Medical Center
Jupiter, Florida, 33458, United States
CCOP - Mount Sinai Medical Center
Miami Beach, Florida, 33140, United States
Cancer Research Center of Hawaii
Honolula, Hawaii, 96813, United States
OnCare Hawaii, Incorporated - Lusitana
Honolulu, Hawaii, 96813, United States
Queen's Cancer Institute at Queen's Medical Center
Honolulu, Hawaii, 96813, United States
Straub Clinic and Hospital, Incorporated
Honolulu, Hawaii, 96813, United States
OnCare Hawaii, Incorporated - Kuakini
Honolulu, Hawaii, 96817, United States
St. Francis Medical Center
Honolulu, Hawaii, 96817, United States
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii, 96826, United States
Tripler Army Medical Center
Honolulu, Hawaii, 96859, United States
Kapiolani Medical Center at Pali Momi
‘Aiea, Hawaii, 96701, United States
Saint Alphonsus Cancer Care Center at Saint Alphonsus Regional Medical Center
Boise, Idaho, 83706, United States
St. Luke's Mountain States Tumor Institute - Boise
Boise, Idaho, 83712, United States
North Idaho Cancer Center
Coeur d'Alene, Idaho, 83814, United States
Saint Anthony's Hospital at Saint Anthony's Health Center
Alton, Illinois, 62002, United States
Rush-Copley Cancer Care Center
Aurora, Illinois, 60507, United States
Medical and Surgical Specialists, L L C
Galesburg, Illinois, 61401, United States
Joliet Oncology Hematology Associates, Limited - West
Joliet, Illinois, 60435, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center
Maywood, Illinois, 60153, United States
Trinity Medical Center - East
Moline, Illinois, 61265, United States
Good Samaritan Regional Health Center
Mount Vernon, Illinois, 62864, United States
Hematology Oncology Consultants Ltd.
Naperville, Illinois, 60540, United States
Edward Hospital Cancer Center
Naperville, Illinois, 60566, United States
Saint James Hospital and Health Centers Comprehensive Cancer Institute - Olympia Fields
Olympia Fields, Illinois, 60461, United States
Swedish American Hospital
Rockford, Illinois, 61104, United States
Carle Cancer Center at Carle Foundation Hospital
Urbana, Illinois, 61801, United States
CCOP - Carle Cancer Center
Urbana, Illinois, 61801, United States
St. Francis Hospital and Health Centers
Beech Grove, Indiana, 46107, United States
Fort Wayne Medical Oncology and Hematology
Fort Wayne, Indiana, 46815, United States
Center for Cancer Care at Goshen Health System
Goshen, Indiana, 46527, United States
Saint Anthony Memorial Health Centers
Michigan City, Indiana, 46360, United States
Hematology Oncology Associates of the Quad Cities
Bettendorf, Iowa, 52722, United States
Saint Anthony Regional Hospital
Carroll, Iowa, 51401, United States
St. Luke's Hospital
Cedar Rapids, Iowa, 52402, United States
Cedar Rapids Oncology Associates
Cedar Rapids, Iowa, 52403, United States
Mercy Regional Cancer Center at Mercy Medical Center
Cedar Rapids, Iowa, 52403, United States
Alegent Health Mercy Hospital
Council Bluffs, Iowa, 51503, United States
Genesis Regional Cancer Center at Genesis Medical Center
Davenport, Iowa, 52803, United States
Genesis Medical Center - West Campus
Davenport, Iowa, 52804, United States
Mercy Capitol Hospital
Des Moines, Iowa, 50307, United States
CCOP - Iowa Oncology Research Association
Des Moines, Iowa, 50309, United States
John Stoddard Cancer Center at Iowa Methodist Medical Center
Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates at John Stoddard Cancer Center
Des Moines, Iowa, 50309, United States
Medical Oncology and Hematology Associates at Mercy Cancer Center
Des Moines, Iowa, 50314, United States
Mercy Cancer Center at Mercy Medical Center - Des Moines
Des Moines, Iowa, 50314, United States
John Stoddard Cancer Center at Iowa Lutheran Hospital
Des Moines, Iowa, 50316, United States
Alegent Health Community Memorial Hospital
Missouri Valley, Iowa, 51555, United States
Burgess Health Center
Onawa, Iowa, 51040, United States
Siouxland Regional Cancer Center
Sioux City, Iowa, 51101-1733, United States
Siouxland Hematology-Oncology Associates at June E. Nylen Cancer Center
Sioux City, Iowa, 51101, United States
Mercy Medical Center - Sioux City
Sioux City, Iowa, 51104, United States
St. Luke's Regional Medical Center
Sioux City, Iowa, 51104, United States
Medical Oncology and Hematology Associates - West Des Moines
West Des Moines, Iowa, 50266, United States
Cancer Center of Kansas, P.A. - Chanute
Chanute, Kansas, 66720, United States
Cancer Center of Kansas, P.A. - Dodge City
Dodge City, Kansas, 67801, United States
Cancer Center of Kansas, P.A. - El Dorado
El Dorado, Kansas, 67042, United States
Kansas Masonic Cancer Research Institute at the University of Kansas Medical Center
Kansas City, Kansas, 66160, United States
Cancer Center of Kansas, P.A. - Kingman
Kingman, Kansas, 67068, United States
Southwest Medical Center
Liberal, Kansas, 67901, United States
Cancer Center of Kansas, P.A. - Newton
Newton, Kansas, 67114, United States
Cancer Center of Kansas, P.A. - Parsons
Parsons, Kansas, 67357, United States
Cancer Center of Kansas, P.A. - Pratt
Pratt, Kansas, 67124, United States
Cancer Center of Kansas, P.A. - Salina
Salina, Kansas, 67042, United States
Salina Regional Health Center
Salina, Kansas, 67401, United States
Stormont-Vail Cancer Center
Topeka, Kansas, 66604, United States
St. Francis Comprehensive Cancer Center
Topeka, Kansas, 66606, United States
Cancer Center of Kansas, P.A. - Wellington
Wellington, Kansas, 67152, United States
Associates in Womens Health, P.A. - North Review
Wichita, Kansas, 67203, United States
Cancer Center of Kansas, P.A. - Medical Arts Tower
Wichita, Kansas, 67208, United States
Cancer Center of Kansas, P.A. - Wichita
Wichita, Kansas, 67214, United States
CCOP - Wichita
Wichita, Kansas, 67214, United States
Via Christi Cancer Center at Via Christi Regional Medical Center
Wichita, Kansas, 67214, United States
Cancer Center of Kansas, P.A. - Winfield
Winfield, Kansas, 67156, United States
Markey Cancer Center at University of Kentucky Chandler Medical Center
Lexington, Kentucky, 40536, United States
Baton Rouge General Regional Cancer Center
Baton Rouge, Louisiana, 70806, United States
Mary Bird Perkins Cancer Center - Baton Rouge
Baton Rouge, Louisiana, 70809, United States
MBCCOP - LSU Health Sciences Center
New Orleans, Louisiana, 70112, United States
Medical Center of Louisiana - New Orleans
New Orleans, Louisiana, 70112, United States
Cancer Treatment Center at Christus Schumpert St. Mary Place
Shreveport, Louisiana, 71101, United States
CancerCare of Maine at Eastern Maine Medial Center
Bangor, Maine, 04401, United States
Tufts - New England Medical Center
Boston, Massachusetts, 02111, United States
Cancer Research Center at Boston Medical Center
Boston, Massachusetts, 02118, United States
Commonwealth Hematology-Oncology P. C. - Quincy
Quincy, Massachusetts, 02169, United States
Hickman Cancer Center at Bixby Medical Center
Adrian, Michigan, 49221, United States
Battle Creek Health System Cancer Care Center
Battle Creek, Michigan, 49017, United States
Mecosta County General Hospital
Big Rapids, Michigan, 49307, United States
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, 48202, United States
CCOP - Grand Rapids
Grand Rapids, Michigan, 49503, United States
Lacks Cancer Center at Saint Mary's Mercy Medical Center
Grand Rapids, Michigan, 49503, United States
Spectrum Health Cancer Care - Butterworth Campus
Grand Rapids, Michigan, 49503, United States
Metropolitan Hospital
Grand Rapids, Michigan, 49506, United States
Spectrum Health Hospital - Blodgett Campus
Grand Rapids, Michigan, 49506, United States
Holland Community Hospital
Holland, Michigan, 49423, United States
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007, United States
West Michigan Cancer Center
Kalamazoo, Michigan, 49007, United States
Borgess Medical Center
Kalamazooaa, Michigan, 49001, United States
Haematology-Oncology Associates of Ohio and Michigan, P.C.
Lambertville, Michigan, 48144, United States
Community Cancer Center of Monroe
Monroe, Michigan, 48162, United States
Mercy Memorial Hospital System
Monroe, Michigan, 48162, United States
Ted B. Wahby Cancer Center at Mount Clemens General Hospital
Mount Clemens, Michigan, 48043, United States
Hackley Hospital
Muskegon, Michigan, 49443, United States
Northern Michigan Hospital
Petoskey, Michigan, 49770, United States
William Beaumont Hospital - Royal Oak Campus
Royal Oak, Michigan, 48073, United States
Providence Cancer Institute at Providence Hospital - Southfield Campus
Southfield, Michigan, 48075, United States
Munson Medical Center
Traverse City, Michigan, 49684, United States
Fairview Ridges Hospital
Burnsville, Minnesota, 55337, United States
Mercy and Unity Cancer Center at Mercy Hospital
Coon Rapids, Minnesota, 55433, United States
Cancer Care Center at St. Luke's Hospital
Duluth, Minnesota, 55805, United States
CCOP - Duluth
Duluth, Minnesota, 55805, United States
Miller-Dwan Medical Center
Duluth, Minnesota, 55805, United States
St. Mary's - Duluth Clinic Cancer Center
Duluth, Minnesota, 55805, United States
Fairview Southdale Hospital
Edina, Minnesota, 55435, United States
Mercy and Unity Cancer Center at Unity Hospital
Fridley, Minnesota, 55432, United States
Hutchinson Area Health Care
Hutchinson, Minnesota, 55350, United States
Meeker County Memorial Hospital
Litchfield, Minnesota, 55355, United States
St. John's Hospital
Maplewood, Minnesota, 55109, United States
Virginia Piper Cancer Institute at Abbott-Northwestern Hospital
Minneapolis, Minnesota, 55407, United States
Hennepin County Medical Center - Minneapolis
Minneapolis, Minnesota, 55415, United States
Hubert H. Humphrey Cancer Center at North Memorial Medical Center
Robbinsdale, Minnesota, 55422, United States
CCOP - Metro-Minnesota
Saint Louis Park, Minnesota, 55416, United States
Park Nicollet Health Services
Saint Louis Park, Minnesota, 55416, United States
Regions Hospital Cancer Care Center
Saint Paul, Minnesota, 55101, United States
St. Joseph's Hospital
Saint Paul, Minnesota, 55102, United States
United Hospital
Saint Paul, Minnesota, 55102, United States
Saint Francis Cancer Center
Shakopee, Minnesota, 55379, United States
Ridgeview Medical Center
Waconia, Minnesota, 55387, United States
Woodwinds Hospital
Woodbury, Minnesota, 55125, United States
University of Mississippi Medical Center
Jackson, Mississippi, 39216, United States
St. Francis Medical Center
Cape Girardeau, Missouri, 63701, United States
Southeast Missouri Regional Cancer Center at Southeast Missouri Hospital
Gape Girardeau, Missouri, 63701, United States
CCOP - Kansas City
Kansas City, Missouri, 64131, United States
CCOP - Cancer Research for the Ozarks
Springfield, Missouri, 65802, United States
St. John's Regional Health Center
Springfield, Missouri, 65804, United States
Hulston Cancer Center at Cox Medical Center South
Springfield, Missouri, 65807, United States
Missouri Baptist Cancer Center
St Louis, Missouri, 63131, United States
CCOP - St. Louis-Cape Girardeau
St Louis, Missouri, 63141, United States
David C. Pratt Cancer Center at St. John's Mercy
St Louis, Missouri, 63141, United States
CCOP - Montana Cancer Consortium
Billings, Montana, 59101, United States
Deaconess Billings Clinic - Downtown
Billings, Montana, 59101, United States
Hematology-Oncology Centers of the Northern Rockies - Billings
Billings, Montana, 59101, United States
Northern Rockies Radiation Oncology Center
Billings, Montana, 59101, United States
St. Vincent Healthcare
Billings, Montana, 59101, United States
Deaconess Billings Clinic Cancer Center
Billings, Montana, 59107, United States
Bozeman Deaconess Hospital
Bozeman, Montana, 59715, United States
Internal Medicine Associates of Bozeman
Bozeman, Montana, 59715, United States
St. James Community Hospital
Butte, Montana, 59701, United States
Great Falls Clinic
Great Falls, Montana, 59405, United States
Sletten Regional Cancer Institute
Great Falls, Montana, 59405, United States
St. Peter's Hospital
Helena, Montana, 59601, United States
Glacier Oncology, PLLC
Kalispell, Montana, 59901, United States
Kalispell Medical Oncology
Kalispell, Montana, 59901, United States
Kalispell Regional Medical Center
Kalispell, Montana, 59901, United States
Eastern Montana Cancer Center
Miles City, Montana, 59301, United States
Community Medical Center
Missoula, Montana, 59801, United States
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center
Missoula, Montana, 59802, United States
Montana Cancer Specialists at Montana Cancer Center
Missoula, Montana, 59802, United States
Fremont Area Medical Center
Fremont, Nebraska, 68025, United States
Good Samaritan Health Systems
Kearney, Nebraska, 68847, United States
CCOP - Missouri Valley Cancer Consortium
Omaha, Nebraska, 68106, United States
Immanuel Medical Center
Omaha, Nebraska, 68122, United States
Bergan Mercy Medical Center
Omaha, Nebraska, 68124, United States
Creighton University Medical Center
Omaha, Nebraska, 68131, United States
Midlands Cancer Center at Midlands Community Hospital
Papillion, Nebraska, 68046, United States
University Medical Center of Southern Nevada
Las Vegas, Nevada, 89102, United States
CCOP - Nevada Cancer Research Foundation
Las Vegas, Nevada, 89106, United States
Englewood Hospital and Medical Center
Englewood, New Jersey, 07631, United States
University of New Mexico Cancer Research and Treatment Center
Albuquerque, New Mexico, 87106, United States
Lovelace Medical Center
Albuquerque, New Mexico, 87108, United States
New Mexico Cancer Care Associates
Santa Fe, New Mexico, 87505, United States
Roswell Park Cancer Institute
Buffalo, New York, 14263, United States
Cancer Care Center at Catskill Regional Medical Center
Harris, New York, 12742, United States
St. Vincent's Comprehensive Cancer Center - Manhattan
New York, New York, 10011, United States
Highland Hospital of Rochester
Rochester, New York, 14620, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center
Rochester, New York, 14642, United States
Hope A Women's Cancer Center
Asheville, North Carolina, 28801, United States
Mission Hospitals - Memorial Campus
Asheville, North Carolina, 28801, United States
Wayne Memorial Hospital, Incorporated
Goldsboro, North Carolina, 27534, United States
Leo W. Jenkins Cancer Center at Pitt County Memorial Hospital
Greenville, North Carolina, 27858, United States
Lenoir Memorial Cancer Center
Kinston, North Carolina, 28501, United States
Rutherford Hospital
Rutherfordton, North Carolina, 28139, United States
Forsyth Regional Cancer Center at Forsyth Medical Center
Winston-Salem, North Carolina, 27103, United States
Bismarck Cancer Center
Bismarck, North Dakota, 58501, United States
Cancer Care Center at Medcenter One Hospital
Bismarck, North Dakota, 58501, United States
Mid Dakota Clinic, P. C.
Bismarck, North Dakota, 58501, United States
St. Alexius Medical Center
Bismarck, North Dakota, 58501, United States
Altru Cancer Center at Altru Hospital
Grand Forks, North Dakota, 58201, United States
Wood County Oncology Center
Bowling Green, Ohio, 43402, United States
Charles M. Barrett Cancer Center at University Hospital
Cincinnati, Ohio, 45267, United States
Grandview Hospital
Dayton, Ohio, 45405, United States
Good Samaritan Hospital
Dayton, Ohio, 45406, United States
David L. Rike Cancer Center at Miami Valley Hospital
Dayton, Ohio, 45409, United States
Samaritan North Cancer Care Center
Dayton, Ohio, 45415, United States
Veterans Affairs Medical Center - Dayton
Dayton, Ohio, 45428, United States
CCOP - Dayton
Dayton, Ohio, 45429, United States
Blanchard Valley Medical Associates
Findlay, Ohio, 45840, United States
Fremont Memorial Hospital
Fremont, Ohio, 43420, United States
Kenton Oncology, Incorporated
Kenton, Ohio, 43326, United States
Charles F. Kettering Memorial Hospital
Kettering, Ohio, 45429, United States
St. Rita's Medical Center
Lima, Ohio, 45801, United States
Lima Memorial Hospital
Lima, Ohio, 45804, United States
MedCentral - Mansfield Hospital
Mansfield, Ohio, 44903, United States
Northwest Ohio Oncology Center
Maumee, Ohio, 43537, United States
St. Luke's Hospital
Maumee, Ohio, 43537, United States
Middletown Regional Hospital
Middletown, Ohio, 45044, United States
St. Charles Mercy Hospital
Oregon, Ohio, 43616, United States
Toledo Clinic - Oregon
Oregon, Ohio, 43616, United States
Firelands Regional Medical Center
Sandusky, Ohio, 44870, United States
North Coast Cancer Care, Incorporated
Sandusky, Ohio, 44870, United States
Promedica Cancer Center at Flower Hospital
Sylvania, Ohio, 43560, United States
Mercy Hospital of Tiffin
Tiffin, Ohio, 44883, United States
Toledo Hospital
Toledo, Ohio, 43606, United States
St. Vincent Mercy Medical Center
Toledo, Ohio, 43608, United States
Medical College of Ohio Cancer Institute
Toledo, Ohio, 43614, United States
CCOP - Toledo Community Hospital
Toledo, Ohio, 43623, United States
Toledo Clinic, Incorporated - Main Clinic
Toledo, Ohio, 43623, United States
Toledo Surgical Specialists
Toledo, Ohio, 43623, United States
UVMC Cancer Care Center at Upper Valley Medical Center
Troy, Ohio, 45373, United States
Fulton County Health Center
Wauseon, Ohio, 43567, United States
United States Air Force Medical Center Wright-Patterson
Wright-Patterson AFB, Ohio, 45433-5529, United States
Ruth G. McMillan Cancer Center at Greene Memorial Hospital
Xenia, Ohio, 45385, United States
Natalie Warren Bryant Cancer Center at St. Francis Hospital
Tulsa, Oklahoma, 74136, United States
Legacy Mount Hood Medical Center
Glesham, Oregon, 97030, United States
Providence Milwaukie Hospital
Milwaukie, Oregon, 97222, United States
Legacy Good Samaritan Hospital & Medical Center Comprehensive Cancer Center
Portland, Oregon, 97210, United States
Providence Cancer Center at Providence Portland Medical Center
Portland, Oregon, 97213, United States
CCOP - Columbia River Oncology Program
Portland, Oregon, 97225, United States
Providence St. Vincent Medical Center
Portland, Oregon, 97225, United States
Institute of Oncology at Vilnius University
Portland, Oregon, 97227, United States
Cancer Institute at Oregon Health and Science University
Portland, Oregon, 97239, United States
Salem Hospital Regional Cancer Center
Salem, Oregon, 97309, United States
Legacy Meridian Park Hospital
Tualatin, Oregon, 97062, United States
Morgan Cancer Center at Lehigh Valley Hospital - Cedar Crest
Allentown, Pennsylvania, 18105, United States
Jennersville Regional Hospital
West Grove, Pennsylvania, 19390, United States
Rose Ramer Cancer Clinic at Anderson Area Medical Center
Anderson, South Carolina, 29621, United States
Roper St. Francis Cancer Center at Roper Hospital
Charleston, South Carolina, 29401, United States
Gibbs Regional Cancer Center at Spartanburg Regional Medical Center
Spartanburg, South Carolina, 29303, United States
CCOP - Upstate Carolina
Spartanburg, South Carolina, 29304, United States
Oncology Services of Aberdeen
Aberdeen, South Dakota, 57401, United States
Rapid City Regional Hospital
Rapid City, South Dakota, 57701, United States
MBCCOP - Meharry Medical College - Nashville
Nashville, Tennessee, 37208-3599, United States
Harrington Cancer Center
Amarillo, Texas, 79106, United States
Seton Shivers Cancer Program at Brackenridge Hospital
Austin, Texas, 78701, United States
Medical City Dallas Hospital
Dallas, Texas, 75230, United States
Brooke Army Medical Center
Fort Sam Houston, Texas, 78234, United States
Wilford Hall Medical Center
Lackland Air Force Base, Texas, 78236, United States
UMC Southwest Cancer and Research Center
Lubbock, Texas, 79415, United States
Veterans Affairs Medical Center - San Antonio (Murphy)
San Antonio, Texas, 78209, United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78229-3900, United States
Cancer Therapy and Research Center
San Antonio, Texas, 78229, United States
University Hospital - San Antonio
San Antonio, Texas, 78229, United States
CCOP - Scott and White Hospital
Temple, Texas, 76508, United States
American Fork Hospital
American Fork, Utah, 84003, United States
Logan Regional Hospital
Logan, Utah, 84321, United States
Cottonwood Hospital Medical Center
Murray, Utah, 84107, United States
McKay-Dee Hospital Center
Ogden, Utah, 84403, United States
Utah Valley Regional Medical Center - Provo
Provo, Utah, 84603, United States
Utah Cancer Specialists at UCS Cancer Center
Salt Lake City, Utah, 84106, United States
Huntsman Cancer Institute at University of Utah
Salt Lake City, Utah, 84112, United States
LDS Hospital
Salt Lake City, Utah, 84143, United States
Dixie Regional Medical Center
St. George, Utah, 84770, United States
Danville Regional Medical Center
Danville, Virginia, 24541, United States
Auburn Regional Center for Cancer Care
Auburn, Washington, 98002, United States
St. Joseph Hospital Community Cancer Center
Bellingham, Washington, 98225, United States
Olympic Hematology and Oncology
Bremerton, Washington, 98310, United States
Providence Centralia Hospital Regional Cancer Center
Centralia, Washington, 98531, United States
St. Francis Hospital
Federal Way, Washington, 98003, United States
Skagit Valley Hospital Cancer Care Center
Mount Vernon, Washington, 98273, United States
Providence St. Peter Hospital Regional Cancer Center
Olympia, Washington, 95806, United States
Capital Medical Center
Olympia, Washington, 98507, United States
Olympic Medical Center
Port Angeles, Washington, 98362, United States
Good Samaritan Cancer Center
Puyallup, Washington, 98372, United States
Valley Medical Center
Renton, Washington, 98055, United States
CCOP - Virginia Mason Research Center
Seattle, Washington, 98101, United States
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98104, United States
Group Health Central Hospital
Seattle, Washington, 98104, United States
Harborview Medical Center
Seattle, Washington, 98104, United States
Swedish Cancer Institute at Swedish Medical Center - First Hill Campus
Seattle, Washington, 98114, United States
University Cancer Center at University of Washington Medical Center
Seattle, Washington, 98195, United States
North Puget Oncology at United General Hospital
Sedro-Woolley, Washington, 98284, United States
Cancer Care Northwest - Spokane South
Spokane, Washington, 99202, United States
Allenmore Hospital
Tacoma, Washington, 98405, United States
CCOP - Northwest
Tacoma, Washington, 98405, United States
St. Joseph Medical Center at Franciscan Health System
Tacoma, Washington, 98405, United States
Madigan Army Medical Center
Tacoma, Washington, 98431, United States
St. Clare Hospital
Tacoma, Washington, 98499, United States
Southwest Washington Medical Center Cancer Center
Vancouver, Washington, 98668, United States
Central Washington Hospital
Wenatchee, Washington, 98801, United States
Wenatchee Valley Clinic
Wenatchee, Washington, 98801, United States
North Star Lodge Cancer Center
Yakima, Washington, 98902, United States
Washington Hematology - Oncology Specialists
Yakima, Washington, 98902, United States
Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601, United States
All Saints Cancer Center at All Saints Healthcare
Racine, Wisconsin, 53405, United States
Welch Cancer Center
Sheridan, Wyoming, 82801, United States
Related Publications (3)
Slovak ML, Bedell V, Lew D, et al.: Screening for clonal hematopoiesis as a predictive marker for development of t-AML following adjuvant therapy for breast cancer (S0012). [Abstract] J Clin Oncol 25 (Suppl 18): A-11051, 2007.
RESULTEllis GK, Barlow WE, Gralow JR, Hortobagyi GN, Russell CA, Royce ME, Perez EA, Lew D, Livingston RB. Phase III comparison of standard doxorubicin and cyclophosphamide versus weekly doxorubicin and daily oral cyclophosphamide plus granulocyte colony-stimulating factor as neoadjuvant therapy for inflammatory and locally advanced breast cancer: SWOG 0012. J Clin Oncol. 2011 Mar 10;29(8):1014-21. doi: 10.1200/JCO.2009.27.6543. Epub 2011 Jan 10.
PMID: 21220618RESULTSlovak ML, Bedell V, Lew D, Albain KS, Ellis GK, Livingston RB, Martino S, Perez EA, Hortobagyi GN, Sher D, Stock W. Screening for clonal hematopoiesis as a predictive marker for development of therapy-related myeloid neoplasia (t-MN) following neoadjuvant therapy for breast cancer: a Southwest Oncology Group study (S0012). Breast Cancer Res Treat. 2010 Jan;119(2):391-8. doi: 10.1007/s10549-009-0597-5.
PMID: 19851858DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Georgiana K. Ellis, MD
Seattle Cancer Care Alliance
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Allocation
- RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- NETWORK
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 6, 2001
First Posted
January 27, 2003
Study Start
May 1, 2001
Primary Completion
September 1, 2006
Study Completion
February 1, 2012
Last Updated
January 24, 2013
Record last verified: 2013-01