Insulin Resistance and Blood Pressure Regulation in Blacks

NCT00005164 | Completed

• 2 other identifiers: 1036R01HL031802
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To determine the role of insulin resistance in peripheral vascular dynamics, sodium sensitivity, and blood pressure regulation in a young representative Black population and in a group of young Blacks at high risk for hypertension.

Conditions

Cardiovascular Diseases; Hypertension; Heart Diseases; Insulin Resistance

Eligibility Criteria

• Age: Up to 100 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Related Publications (22)

• Canessa M, Spalvins A, Adragna N, Falkner B. Red cell sodium countertransport and cotransport in normotensive and hypertensive blacks. Hypertension. 1984 May-Jun;6(3):344-51. doi: 10.1161/01.hyp.6.3.344.

  PMID: 6735456 BACKGROUND

• Chinese M, Solomon H, Falkner B, Adragna N, Ellison RC: Familial Aggregation of Sodium Countertransport and Cotransport and Essential Hypertension in: Topics on Pathophysiology of Hypertension. Villareal H, Sambhi MP, Nijhoff Publish. Boston, p. 78-87, 1984

  BACKGROUND

• Falkner B, Katz S, Chinese M, Kushner H: The Response to Chronic Oral Sodium Loading in Young Blacks. Hypertension, 8 (Suppl I): I-165-168, 1986

  BACKGROUND

• Falkner B. Cardiovascular characteristics of the young with borderline hypertension. J Cardiovasc Pharmacol. 1986;8 Suppl 5:S44-7. doi: 10.1097/00005344-198608005-00009.

  PMID: 2427884 BACKGROUND

• Canessa M, Bize I, Spalvins A, Falkner B, Katz S. Na-K-C1 cotransport and Na pump in red cells of young blacks and blood pressure response to salt loading. J Clin Hypertens. 1986 Jun;2(2):101-8.

  PMID: 2428944 BACKGROUND

• Falkner B, Ragonesi S. Psychosocial stress and reactivity as risk factors of cardiovascular disease. J Am Acad Child Psychiatry. 1986 Nov;25(6):779-84. doi: 10.1016/s0002-7138(09)60195-3. No abstract available.

  PMID: 3794120 BACKGROUND

• Falkner B, Light K: The Interactive Effects of Stress and Dietary Sodium on Cardiovascular Reactivity. In: J Hypertens, Stress, Reactivity, and Cardiovascular Disease: Status and Prospects. Eds. Matthews L, Weiss SM, Detre T, Dembroski T, Falkner B, Manuch S, Williams R (Eds), John Wiley and Sons, Inc. New York, p 329-341, 1986

  BACKGROUND

• Falkner B: Mild Hypertension in Adolescence. In: Mild Hypertension: From Drug Trials to Practice. Strasser T, Gaten D, (Eds) Raven Press, New York, p 279-283, 1987

  BACKGROUND

• Falkner B, Kushner H, Khalsa DK, Canessa M, Katz S. Sodium sensitivity, growth and family history of hypertension in young blacks. J Hypertens Suppl. 1986 Dec;4(5):S381-3.

  PMID: 3471912 BACKGROUND

• Falkner B: Reactivity to Mental Stress in Hypertension and Prehypertension in: Handbook of Hypertension, Vol. 10. Behavioral Factors in Hypertension, Editor Julius S. and Bassett DR. Elsevier Science Publishers. B.V., 1987

  BACKGROUND

• Falkner B. Sodium sensitivity: a determinant of essential hypertension. J Am Coll Nutr. 1988 Feb;7(1):35-41. doi: 10.1080/07315724.1988.10720218.

  PMID: 3278039 BACKGROUND

• Falkner B: Measurement of Volume Regulation: Renal Function. in: Schneiderman N, Kaufman P and Weiss SM (Eds). Handbook of Research Methods in Cardiovascular Behavioral Medicine. New York: Plenum Publishing Corporation, 1989

  BACKGROUND

• Falkner B. Vascular reactivity and hypertension in childhood. Semin Nephrol. 1989 Sep;9(3):247-52. No abstract available.

  PMID: 2675243 BACKGROUND

• Santangelo K, Falkner B, Kushner H. Forearm hemodynamics at rest and stress in borderline hypertensive adolescents. Am J Hypertens. 1989 Jan;2(1):52-6. doi: 10.1093/ajh/2.1.52.

  PMID: 2914085 BACKGROUND

• Falkner B, Kushner H. Race differences in stress-induced reactivity in young adults. Health Psychol. 1989;8(5):613-27. doi: 10.1037//0278-6133.8.5.613.

  PMID: 2630296 BACKGROUND

• Falkner B, Kushner H. Effect of chronic sodium loading on cardiovascular response in young blacks and whites. Hypertension. 1990 Jan;15(1):36-43. doi: 10.1161/01.hyp.15.1.36.

  PMID: 2295513 BACKGROUND

• Falkner B. Differences in blacks and whites with essential hypertension: biochemistry and endocrine. State of the art lecture. Hypertension. 1990 Jun;15(6 Pt 2):681-6. doi: 10.1161/01.hyp.15.6.681.

  PMID: 2190920 BACKGROUND

• Falkner B, Hulman S, Tannenbaum J, Kushner H. Insulin resistance and blood pressure in young black men. Hypertension. 1990 Dec;16(6):706-11. doi: 10.1161/01.hyp.16.6.706.

  PMID: 2246037 BACKGROUND

• Canessa M, Laski C, Falkner B. Red blood cell Na+ transport as a predictor of blood pressure response to Na+ load in young blacks and whites. Hypertension. 1990 Nov;16(5):508-14. doi: 10.1161/01.hyp.16.5.508.

  PMID: 2228151 BACKGROUND

• Falkner B: Etiologic Factors in Essential Hypertension. Loggie J, Robson A (Eds), in: Pediatric and Adolescent Hypertension, 1992.

  BACKGROUND

• Falkner B, Rabinowitz AI, Michel SH: Nutrition and Blood Pressure in Childhood: In: Nutritional Factors in Hypertension, Langford H, Levine B (Eds), Alan R Liss, Inc., New York, 1990.

  BACKGROUND

• Falkner B, Kushner H. Interaction of sodium sensitivity and stress in young adults. Hypertension. 1991 Jan;17(1 Suppl):I162-5. doi: 10.1161/01.hyp.17.1_suppl.i162.

  PMID: 1986997 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; Hypertension; Heart Diseases; Insulin Resistance

Condition Hierarchy (Ancestors)

Vascular Diseases; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: September 1, 1983
• Study Completion: August 1, 1991
• Last Updated: May 13, 2016

Record last verified: 2000-06