Charleston Heart Study - Predictors of Coronary Disease in Blacks

NCT00005165 | Completed

• 2 other identifiers: 1038R01HL031397
• Study Type: observational
• Target: N/A
• Locations: 0 countries
• Sites: N/A

Brief Summary

To examine the role of isolated systolic hypertension and other predictors of all-cause and coronary heart disease mortality in elderly Blacks and whites of the Charleston Heart Study cohort of 1960 and to compare and pool those findings with the Evans County Heart Study findings in order to develop a logistic risk function for Blacks. Also, to identify predictors of physical functioning in older Blacks and whites and to prepare rosters of the off-spring of the Charleston cohort for future studies of genetic/familial influences on cardiovascular disease.

Conditions

Cardiovascular Diseases; Coronary Disease; Hypertension; Heart Diseases

Eligibility Criteria

• Age: Up to 100 Years
• Sex: male
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

• National Heart, Lung, and Blood Institute (NHLBI): lead

Related Publications (15)

• Lackland DT, Keil JE. Epidemiology of hypertension in African Americans. Semin Nephrol. 1996 Mar;16(2):63-70.

  PMID: 8668862 BACKGROUND

• Keil JE, Gazes PC, LoadHolt CB, Gross AJ, Sutherland S, Tyroler HA, Knowes M, Rust PF: Coronary Heart Disease and Its Predictors in Charleston, South Carolina Women. In: Coronary Heart Disease in Women. Eaker E et al (Eds). Haymarket Doyma, Inc., New York, N.Y., 1987

  BACKGROUND

• Weinrich SP, Weinrich MC, Keil JE, Gazes PC, Potter E. The John Henryism and Framingham type A scales. Measurement properties in elderly blacks and whites. Am J Epidemiol. 1988 Jul;128(1):165-78. doi: 10.1093/oxfordjournals.aje.a114938.

  PMID: 3381824 BACKGROUND

• Keil JE, Gazes PC, Sutherland SE, Rust PF, Branch LG, Tyroler HA. Predictors of physical disability in elderly blacks and whites of the Charleston Heart Study. J Clin Epidemiol. 1989;42(6):521-9. doi: 10.1016/0895-4356(89)90148-0.

  PMID: 2525608 BACKGROUND

• Stevens J, Keil JE, Waid LR, Gazes PC. Accuracy of current, 4-year, and 28-year self-reported body weight in an elderly population. Am J Epidemiol. 1990 Dec;132(6):1156-63. doi: 10.1093/oxfordjournals.aje.a115758.

  PMID: 2260547 BACKGROUND

• Knapp RG, Sutherland SE, Keil JE, Rust PF, Lackland DT. A comparison of the effects of cholesterol on CHD mortality in black and white women: twenty-eight years of follow-up in the Charleston Heart Study. J Clin Epidemiol. 1992 Oct;45(10):1119-29. doi: 10.1016/0895-4356(92)90152-d.

  PMID: 1474408 BACKGROUND

• Keil JE, Sutherland SE, Knapp RG, Gazes PC. Serum cholesterol--risk factor for coronary disease mortality in younger and older blacks and whites. The Charleston Heart Study, 1960-1988. Ann Epidemiol. 1992 Jan-Mar;2(1-2):93-9.

  PMID: 1342270 BACKGROUND

• Keil JE, Sutherland SE, Knapp RG, Tyroler HA, Pollitzer WS. Skin color and mortality. Am J Epidemiol. 1992 Dec 1;136(11):1295-302. doi: 10.1093/oxfordjournals.aje.a116441.

  PMID: 1488957 BACKGROUND

• Keil JE, Sutherland SE, Knapp RG, Tyroler HA. Does equal socioeconomic status in black and white men mean equal risk of mortality? Am J Public Health. 1992 Aug;82(8):1133-6. doi: 10.2105/ajph.82.8.1133.

  PMID: 1636835 BACKGROUND

• Lackland DT, Keil JE, Gazes PC, Hames CG, Tyroler HA. Outcomes of black and white hypertensive individuals after 30 years of follow-up. Clin Exp Hypertens. 1995 Oct;17(7):1091-105. doi: 10.3109/10641969509033654.

  PMID: 8556006 BACKGROUND

• Knapp RG, Keil JE, Sutherland SE, Rust PF, Hames C, Tyroler HA. Skin color and cancer mortality among black men in the Charleston Heart Study. Clin Genet. 1995 Apr;47(4):200-6. doi: 10.1111/j.1399-0004.1995.tb03959.x.

  PMID: 7628122 BACKGROUND

• Keil JE, Sutherland SE, Hames CG, Lackland DT, Gazes PC, Knapp RG, Tyroler HA. Coronary disease mortality and risk factors in black and white men. Results from the combined Charleston, SC, and Evans County, Georgia, heart studies. Arch Intern Med. 1995 Jul 24;155(14):1521-7.

  PMID: 7605154 BACKGROUND

• Knapp RG, Schreiner PJ, Sutherland SE, Keil JE, Gilbert GE, Klein RL, Hames C, Tyroler HA. Serum lipoprotein(a) levels in elderly black and white men in the Charleston Heart Study. Clin Genet. 1993 Nov;44(5):225-31. doi: 10.1111/j.1399-0004.1993.tb03887.x.

  PMID: 8313620 BACKGROUND

• Sutherland SE, Gazes PC, Keil JE, Gilbert GE, Knapp RG. Electrocardiographic abnormalities and 30-year mortality among white and black men of the Charleston Heart Study. Circulation. 1993 Dec;88(6):2685-92. doi: 10.1161/01.cir.88.6.2685.

  PMID: 8252679 BACKGROUND

• Keil JE, Sutherland SE, Knapp RG, Lackland DT, Gazes PC, Tyroler HA. Mortality rates and risk factors for coronary disease in black as compared with white men and women. N Engl J Med. 1993 Jul 8;329(2):73-8. doi: 10.1056/NEJM199307083290201.

  PMID: 8510705 BACKGROUND

MeSH Terms

Conditions

Cardiovascular Diseases; Coronary Disease; Hypertension; Heart Diseases

Condition Hierarchy (Ancestors)

Myocardial Ischemia; Vascular Diseases

Study Design

• Study Type: observational
• Sponsor Type: NIH

Study Record Dates

• First Submitted: May 25, 2000
• First Posted: May 26, 2000
• Study Start: January 1, 1984
• Study Completion: March 1, 1995
• Last Updated: February 18, 2016

Record last verified: 2000-04