NCT00005387

Brief Summary

To investigate the genetic determinants of hypertension in three populations of the African diaspora, with a major focus on clarifying the role of genes that code for the renin-angiotensin system (RAS).

Trial Health

100
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Timeline
Completed

Started Sep 1995

Longer than P75 for all trials

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 1, 1995

Completed
4.7 years until next milestone

First Submitted

Initial submission to the registry

May 25, 2000

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 26, 2000

Completed
8.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 1, 2008

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 1, 2008

Completed
Last Updated

July 12, 2016

Status Verified

December 1, 2008

Enrollment Period

13.3 years

First QC Date

May 25, 2000

Last Update Submit

July 11, 2016

Conditions

Cardiovascular DiseasesHeart DiseasesHypertension

Eligibility Criteria

AgeUp to 100 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
No eligibility criteria

Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.

Sponsors & Collaborators

Related Publications (13)

  • Rotimi C, Cooper R, Ogunbiyi O, Morrison L, Ladipo M, Tewksbury D, Ward R. Hypertension, serum angiotensinogen, and molecular variants of the angiotensinogen gene among Nigerians. Circulation. 1997 May 20;95(10):2348-50. doi: 10.1161/01.cir.95.10.2348.

    PMID: 9170394BACKGROUND

  • Rotimi C, Okosun I, Johnson L, Owoaje E, Lawoyin T, Asuzu M, Kaufman J, Adeyemo A, Cooper R. The distribution and mortality impact of chronic energy deficiency among adult Nigerian men and women. Eur J Clin Nutr. 1999 Sep;53(9):734-9. doi: 10.1038/sj.ejcn.1600842.

    PMID: 10509771BACKGROUND

  • Rotimi C, Luke A, Li Z, Compton J, Bowsher R, Cooper R. Heritability of plasma leptin in a population sample of African-American families. Genet Epidemiol. 1997;14(3):255-63. doi: 10.1002/(SICI)1098-2272(1997)14:33.0.CO;2-4.

    PMID: 9181355BACKGROUND

  • Zhu X, McKenzie CA, Forrester T, Nickerson DA, Broeckel U, Schunkert H, Doering A, Jacob HJ, Cooper RS, Rieder MJ. Localization of a small genomic region associated with elevated ACE. Am J Hum Genet. 2000 Nov;67(5):1144-53. doi: 10.1016/S0002-9297(07)62945-0. Epub 2000 Sep 19.

    PMID: 11001581BACKGROUND

  • Lowe WL Jr, Rotimi CN, Luke A, Guo X, Zhu X, Comuzzie AG, Schuh TS, Halbach S, Kotlar TJ, Cooper RS. The beta 3-adrenergic receptor gene and obesity in a population sample of African Americans. Int J Obes Relat Metab Disord. 2001 Jan;25(1):54-60. doi: 10.1038/sj.ijo.0801487.

    PMID: 11244458BACKGROUND

  • Adeyemo AA, Omotade OO, Rotimi CN, Luke AH, Tayo BO, Cooper RS. Heritability of blood pressure in Nigerian families. J Hypertens. 2002 May;20(5):859-63. doi: 10.1097/00004872-200205000-00019.

    PMID: 12011645BACKGROUND

  • Zhu X, Zhang S, Zhao H, Cooper RS. Association mapping, using a mixture model for complex traits. Genet Epidemiol. 2002 Aug;23(2):181-96. doi: 10.1002/gepi.210.

    PMID: 12214310BACKGROUND

  • Huang J, Jiang Y. Genetic linkage analysis of a dichotomous trait incorporating a tightly linked quantitative trait in affected sib pairs. Am J Hum Genet. 2003 Apr;72(4):949-60. doi: 10.1086/374568. Epub 2003 Mar 17.

    PMID: 12644967BACKGROUND

  • Mendez MA, Cooper R, Wilks R, Luke A, Forrester T. Income, education, and blood pressure in adults in Jamaica, a middle-income developing country. Int J Epidemiol. 2003 Jun;32(3):400-8. doi: 10.1093/ije/dyg083.

    PMID: 12777427BACKGROUND

  • Zhu X, Zhang S, Kan D, Cooper R. Haplotype block definition and its application. Pac Symp Biocomput. 2004:152-63. doi: 10.1142/9789812704856_0015.

    PMID: 14992500BACKGROUND

  • Yoo HY, Shevchenko A, Shevchenko A, Dunphy WG. Mcm2 is a direct substrate of ATM and ATR during DNA damage and DNA replication checkpoint responses. J Biol Chem. 2004 Dec 17;279(51):53353-64. doi: 10.1074/jbc.M408026200. Epub 2004 Sep 22.

    PMID: 15448142BACKGROUND

  • Mendez MA, Cooper RS, Luke A, Wilks R, Bennett F, Forrester T. Higher income is more strongly associated with obesity than with obesity-related metabolic disorders in Jamaican adults. Int J Obes Relat Metab Disord. 2004 Apr;28(4):543-50. doi: 10.1038/sj.ijo.0802584.

    PMID: 14770191BACKGROUND

  • Luke A, Adeyemo A, Kramer H, Forrester T, Cooper RS. Association between blood pressure and resting energy expenditure independent of body size. Hypertension. 2004 Mar;43(3):555-60. doi: 10.1161/01.HYP.0000118020.44335.20. Epub 2004 Feb 2.

    PMID: 14757780BACKGROUND

MeSH Terms

Conditions

Cardiovascular DiseasesHeart DiseasesHypertension

Condition Hierarchy (Ancestors)

Vascular Diseases

Study Officials

  • Richard Cooper

    Loyola University

Study Design

Study Type
observational
Sponsor Type
NIH

Study Record Dates

First Submitted

May 25, 2000

First Posted

May 26, 2000

Study Start

September 1, 1995

Primary Completion

December 1, 2008

Study Completion

December 1, 2008

Last Updated

July 12, 2016

Record last verified: 2008-12