Combination Chemotherapy Alone or With Radiation Therapy in Treating Children With Kidney Cancer
NATIONAL WILMS TUMOR STUDY-5 -- THERAPEUTIC TRIAL AND BIOLOGY STUDY
8 other identifiers
interventional
3,031
7 countries
235
Brief Summary
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high energy x-rays to damage tumor cells. It is not yet known whether combination chemotherapy alone or combination chemotherapy plus radiation therapy is more effective for childhood kidney cancer. PURPOSE: Phase III trial to compare the effectiveness of combination chemotherapy with or without radiation therapy in treating children who have kidney cancer.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for phase_3
Started Jul 1995
Longer than P75 for phase_3
235 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
July 1, 1995
CompletedFirst Submitted
Initial submission to the registry
November 1, 1999
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2002
CompletedFirst Posted
Study publicly available on registry
January 27, 2003
CompletedStudy Completion
Last participant's last visit for all outcomes
August 1, 2003
CompletedFebruary 25, 2021
July 1, 2014
6.9 years
November 1, 1999
February 23, 2021
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Progression free survival
Study Arms (9)
Stratum 1
ACTIVE COMPARATORStage I favorable histology (FH) Wilms' tumor, under 24 months of age, and tumor weight less than 550 g: After conventional surgery (nephrectomy), patients receive regimen EE-4A comprising dactinomycin (DACT) IV weekly on weeks 0, 3, 6, 9, 12, 15, and 18 and vincristine sulfate (VCR) IV weekly on weeks 1-10, 12, 15, and 18.
Stratum 2
ACTIVE COMPARATORStage I FH Wilms' tumor and age 24 months and over or tumor weight at least 550 g; stage I focal anaplastic (FA) or diffuse anaplastic (DA) Wilms' tumor: Patients receive regimen EE-4A comprising dactinomycin (DACT) IV weekly on weeks 0, 3, 6, 9, 12, 15, and 18 and vincristine sulfate (VCR) IV weekly on weeks 1-10, 12, 15, and 18.
Stratum 3
ACTIVE COMPARATORStage II FH Wilms' tumor: Patients receive regimen EE-4A comprising dactinomycin (DACT) IV weekly on weeks 0, 3, 6, 9, 12, 15, and 18 and vincristine sulfate (VCR) IV weekly on weeks 1-10, 12, 15, and 18.
Stratum 4
ACTIVE COMPARATORStage III FH Wilms' tumor; stage II or III FA Wilms' tumor: After conventional surgery (nephrectomy), patients receive regimen DD-4A comprising dactinomycin DACT IV weekly on weeks 0, 6, 12, 18, and 24; doxorubicin hydrochloride IV weekly on weeks 3, 9, 15, and 21; and vincristine sulfate VCR IV weekly on weeks 1-10, 12, 15, 18, 21, and 24. Patients also undergo abdominal radiation therapy.
Stratum 5
ACTIVE COMPARATORStage IV FH or FA Wilms' tumor: patients receive regimen DD-4A comprising dactinomycin DACT IV weekly on weeks 0, 6, 12, 18, and 24; doxorubicin hydrochloride IV weekly on weeks 3, 9, 15, and 21; and vincristine sulfate VCR IV weekly on weeks 1-10, 12, 15, 18, 21, and 24. Patients also undergo abdominal radiation therapy, and whole lung radiation therapy (at the discretion of the investigator).
Stratum 6
ACTIVE COMPARATORStage V FH, FA, or DA Wilms' tumor: After bilateral conventional surgery (biopsy), patients with FH receive chemotherapy as in stratum 1 (dactinomycin IV weeks 0, 3, 6, 9, 12, 15, and 18 and vincristine sulfate IV weeks 1-10, 12, 15, and 18) or 4 (dactinomycin IV weeks 0, 6, 12, 18, and 24; doxorubicin hydrochloride IV weeks 3, 9, 15, and 21; and vincristine sulfate VCR IV weeks 1-10, 12, 15, 18, 21, and 24). Patients with FA or DA receive chemotherapy as in stratum 7 (vincristine sulfate VCR IV weeks 1, 2, 4-8, 10-13, 18, and 24; cyclophosphamide sulfate (CTX) IV over 1 hour on days 1-3 of weeks 6, 12, 18, and 24 and on days 1-5 of weeks 3, 9, 15, and 21; doxorubicin hydrochloride IV (beginning after CTX infusion) weeks 0, 6, 12, 18, and 24; and etoposide (VP-16) IV over 1 hour (beginning after CTX infusion) on days 1-5 of weeks 3, 9, 15, and 21. Filgrastim (G-CSF) is administered subcutaneously (SC) beginning 24 hours after completion of chemotherapy.
Stratum 7
ACTIVE COMPARATORStages I-IV clear cell sarcoma): After conventional surgery (nephrectomy), patients receive vincristine sulfate VCR IV weekly on weeks 1, 2, 4-8, 10-13, 18, and 24; cyclophosphamide sulfate (CTX) IV over 1 hour on days 1-3 of weeks 6, 12, 18, and 24 and on days 1-5 of weeks 3, 9, 15, and 21; doxorubicin hydrochloride IV (beginning after CTX infusion) weekly on weeks 0, 6, 12, 18, and 24; and etoposide (VP-16) IV over 1 hour (beginning after CTX infusion) on days 1-5 of weeks 3, 9, 15, and 21. Filgrastim (G-CSF) is administered subcutaneously (SC) beginning 24 hours after completion of chemotherapy and continuing until blood counts recover. Patients also undergo abdominal radiotherapy and whole lung radiotherapy (if pulmonary metastases are present).
Stratum 8
ACTIVE COMPARATORStages II-IV DA Wilms' tumor: After conventional surgery (nephrectomy), Patients receive treatment as in stratum 7 (patients receive vincristine sulfate VCR IV weekly on weeks 1, 2, 4-8, 10-13, 18, and 24; cyclophosphamide sulfate (CTX) IV over 1 hour on days 1-3 of weeks 6, 12, 18, and 24 and on days 1-5 of weeks 3, 9, 15, and 21; doxorubicin hydrochloride IV (beginning after CTX infusion) weekly on weeks 0, 6, 12, 18, and 24; and etoposide (VP-16) IV over 1 hour (beginning after CTX infusion) on days 1-5 of weeks 3, 9, 15, and 21. Filgrastim (G-CSF) is administered subcutaneously (SC) beginning 24 hours after completion of chemotherapy and continuing until blood counts recover. Patients also undergo abdominal radiotherapy and whole lung radiotherapy (if pulmonary metastases are present).
Stratum 9
ACTIVE COMPARATORStages I-IV rhabdoid tumor: After conventional surgery (nephrectomy), patients receive carboplatin IV on days 1-2 and VP-16 IV over 1 hour (beginning after carboplatin infusion) on days 1-3 of weeks 0, 3, 9, 12, 18, and 21 and CTX IV over 1 hour on days 1-5 of weeks 6, 15, and 24. Filgrastim G-CSF is administered as on stratum 7. Patients also undergo radiation therapy. After completion of chemotherapy, patients undergo second-look conventional surgery (laparotomy) and conventional surgery (partial nephrectomy or wedge excision if feasible). After conventional surgery (second-look surgery), patients without persistent or residual disease resume chemotherapy.
Interventions
Source and Pharmacology: An anthracycline antibiotic isolated from cultures of Streptomyces peucetius. Binds to DNA and inhibits nucleic acid synthesis, with its major lethal effect occurring during the S phase of the cell cycle. Has some topoisomerase II inhibitory activity. Since it is primarily excreted by the liver, any liver impairment may enhance toxicity. 40% to 50% is excreted in the bile; \<5% in the urine. The drug has a very short initial t½ of \<20 minutes and a terminal t½ of 17 hours. Animal studies indicate cytotoxic levels persist in tissue for as long as 24 hours.
Eligibility Criteria
Contact the study team to discuss eligibility requirements. They can help determine if this study is right for you.
Sponsors & Collaborators
- Children's Oncology Grouplead
- National Cancer Institute (NCI)collaborator
Study Sites (235)
University of Alabama at Birmingham Comprehensive Cancer Center
Birmingham, Alabama, 35233, United States
University of South Alabama Medical Center
Mobile, Alabama, 36604, United States
Phoenix Children's Hospital
Phoenix, Arizona, 85016-7710, United States
Arizona Cancer Center
Tucson, Arizona, 85724, United States
University of Arkansas for Medical Sciences
Little Rock, Arkansas, 72205, United States
Southern California Permanente Medical Group
Downey, California, 90242, United States
City of Hope Comprehensive Cancer Center
Duarte, California, 91010-3000, United States
Rebecca and John Moores UCSD Cancer Center
La Jolla, California, 92093-0658, United States
Loma Linda University Medical Center
Loma Linda, California, 92354, United States
Jonathan Jaques Children's Cancer Center
Long Beach, California, 90801-1428, United States
Children's Hospital Los Angeles
Los Angeles, California, 90027-0700, United States
Cedars-Sinai Medical Center
Los Angeles, California, 90048, United States
Jonsson Comprehensive Cancer Center, UCLA
Los Angeles, California, 90095-1781, United States
Children's Hospital Central California
Madera, California, 93638-8762, United States
Children's Hospital of Oakland
Oakland, California, 94609-1809, United States
Chao Family Comprehensive Cancer Center
Orange, California, 92868, United States
Children's Hospital of Orange County
Orange, California, 92868, United States
Lucile Packard Children's Hospital at Stanford
Palo Alto, California, 94304, United States
Sutter Cancer Center
Sacramento, California, 95816, United States
University of California Davis Medical Center
Sacramento, California, 95817, United States
Kaiser Permanente Medical Center/Kaiser Foundation Hospital - San Diego
San Diego, California, 92120, United States
Children's Hospital San Diego
San Diego, California, 92123-4282, United States
Kaiser Permanente Medical Center - San Francisco Geary Campus
San Francisco, California, 94115, United States
UCSF Comprehensive Cancer Center
San Francisco, California, 94143-0128, United States
Santa Barbara Cottage Hospital
Santa Barbara, California, 93102, United States
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California, 95051-5386, United States
David Grant Medical Center
Travis Air Force Base, California, 94535, United States
Children's Hospital of Denver
Denver, Colorado, 80218-1088, United States
Childhood Hematology/Oncology Associates
Denver, Colorado, 80218, United States
Presbyterian-St Luke's Medical Center
Denver, Colorado, 80218, United States
University of Connecticut Health Center
Farmington, Connecticut, 06360-7106, United States
Yale Comprehensive Cancer Center
New Haven, Connecticut, 06520-8028, United States
Alfred I. Dupont Institute
Wilmington, Delaware, 19899, United States
Lombardi Cancer Center
Washington D.C., District of Columbia, 20007, United States
Children's National Medical Center
Washington D.C., District of Columbia, 20010-2970, United States
Walter Reed Army Medical Center
Washington D.C., District of Columbia, 20307-5000, United States
Broward General Medical Center
Fort Lauderdale, Florida, 33316, United States
Children's Hospital of Southwest Florida
Fort Myers, Florida, 33908, United States
Shands Hospital and Clinics, University of Florida
Gainesville, Florida, 32610-100277, United States
Joe DiMaggio Children's Hospital at Memorial
Hollywood, Florida, 33021, United States
Nemours Children's Clinic
Jacksonville, Florida, 32207, United States
University of Miami-Jackson Memorial Hospital
Miami, Florida, 33136, United States
Miami Children's Hospital
Miami, Florida, 33155-4069, United States
Baptist Hospital of Miami
Miami, Florida, 33176-2197, United States
Florida Hospital Cancer Institute
Orlando, Florida, 32803, United States
Nemours Children's Clinic-Orlando
Orlando, Florida, 32806, United States
Sacred Heart Children's Hospital
Pensacola, Florida, 32504, United States
All Children's Hospital
St. Petersburg, Florida, 33701, United States
Tampa Children's Hospital
Tampa, Florida, 33677-4227, United States
St. Mary's Hospital
West Palm Beach, Florida, 33407, United States
Emory University Hospital - Atlanta
Atlanta, Georgia, 30322, United States
Children's Healthcare of Atlanta - Scottish Rite
Atlanta, Georgia, 30342, United States
Medical College of Georgia Comprehensive Cancer Center
Augusta, Georgia, 30912-4000, United States
Medical Center of Central Georgia
Macon, Georgia, 31201, United States
Memorial Health University Medical Center, Inc.
Savannah, Georgia, 31403-3089, United States
Cancer Research Center of Hawaii
Honolulu, Hawaii, 96813, United States
MBCCOP - Hawaii
Honolulu, Hawaii, 96813, United States
Tripler Army Medical Center
Honolulu, Hawaii, 96859-5000, United States
Mountain States Tumor Institute
Boise, Idaho, 83712, United States
University of Chicago Cancer Research Center
Chicago, Illinois, 60601, United States
Rush-Presbyterian-St. Luke's Medical Center
Chicago, Illinois, 60612, United States
University of Illinois at Chicago
Chicago, Illinois, 60612, United States
Children's Memorial Hospital - Chicago
Chicago, Illinois, 60614, United States
Hope Children's Hospital
Oak Lawn, Illinois, 60453, United States
Lutheran General Hospital
Park Ridge, Illinois, 60068-1174, United States
Saint Jude Midwest Affiliate
Peoria, Illinois, 61637, United States
Southern Illinois University School of Medicine
Springfield, Illinois, 62794-9658, United States
Indiana University Cancer Center
Indianapolis, Indiana, 46202-5289, United States
St. Vincent Hospital and Health Care Center
Indianapolis, Indiana, 46260, United States
Raymond Blank Memorial Hospital for Children
Des Moines, Iowa, 50308, United States
John Stoddard Cancer Center
Des Moines, Iowa, 50309, United States
Holden Comprehensive Cancer Center
Iowa City, Iowa, 52242-1009, United States
Wesley Medical Center
Wichita, Kansas, 67214, United States
Albert B. Chandler Medical Center, University of Kentucky
Lexington, Kentucky, 40536-0284, United States
Kosair Children's Hospital
Louisville, Kentucky, 40202-3830, United States
Tulane University School of Medicine
New Orleans, Louisiana, 70112, United States
Children's Hospital of New Orleans
New Orleans, Louisiana, 70118, United States
Ochsner Clinic
New Orleans, Louisiana, 70121, United States
Eastern Maine Medical Center
Bangor, Maine, 04401, United States
Maine Children's Cancer Program
Scarborough, Maine, 04074, United States
Marlene and Stewart Greenebaum Cancer Center, University of Maryland
Baltimore, Maryland, 21201-1595, United States
Sinai Hospital of Baltimore
Baltimore, Maryland, 21225, United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Baltimore, Maryland, 21231-2410, United States
Floating Hospital for Children
Boston, Massachusetts, 02111, United States
Dana-Farber Cancer Institute
Boston, Massachusetts, 02115, United States
Baystate Medical Center
Springfield, Massachusetts, 01107, United States
University of Massachusetts Memorial Medical Center - University Campus
Worcester, Massachusetts, 01655, United States
Mott Children's Hospital
Ann Arbor, Michigan, 48109-0914, United States
Children's Hospital of Michigan
Detroit, Michigan, 48201, United States
Henry Ford Hospital
Detroit, Michigan, 48202, United States
St. John Hospital and Medical Center
Detroit, Michigan, 48236, United States
Michigan State University
East Lansing, Michigan, 48824, United States
Hurley Medical Center
Flint, Michigan, 48503, United States
Spectrum Health and DeVos Children's Hospital
Grand Rapids, Michigan, 49503, United States
Bronson Methodist Hospital
Kalamazoo, Michigan, 49007, United States
CCOP - Beaumont
Royal Oak, Michigan, 48073-6769, United States
William Beaumont Hospital
Royal Oak, Michigan, 48073-6769, United States
St. Mary's/Duluth Clinic Cancer Center
Duluth, Minnesota, 55805-1983, United States
Children's Hospitals and Clinics - Minneapolis
Minneapolis, Minnesota, 55404, United States
Mayo Clinic Cancer Center
Rochester, Minnesota, 55905, United States
Children's Hospitals and Clinics of Minnesota
Saint Paul, Minnesota, 55102, United States
University of Mississippi Medical Center
Jackson, Mississippi, 39216-4505, United States
Children's Mercy Hospital
Kansas City, Missouri, 64108, United States
Cardinal Glennon Children's Hospital
St Louis, Missouri, 63104, United States
St. Louis Children's Hospital
St Louis, Missouri, 63110, United States
Children's Hospital of Omaha
Omaha, Nebraska, 68114, United States
University of Nebraska Medical Center
Omaha, Nebraska, 68198-2168, United States
Sunrise Hospital and Medical Center
Las Vegas, Nevada, 89109-2306, United States
Norris Cotton Cancer Center
Lebanon, New Hampshire, 03756-0002, United States
Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
Cancer Institute of New Jersey
New Brunswick, New Jersey, 08903, United States
Newark Beth Israel Medical Center
Newark, New Jersey, 07112-2094, United States
St. Joseph's Hospital and Medical Center
Paterson, New Jersey, 07503, United States
Atlantic Health System
Summit, New Jersey, 07901, United States
University of New Mexico Cancer Research and Treatment Center
Albuquerque, New Mexico, 87131, United States
Cancer Center of Albany Medical Center
Albany, New York, 12208, United States
Brooklyn Hospital Center
Brooklyn, New York, 11201, United States
State University of New York Health Science Center at Brooklyn College of Medicine
Brooklyn, New York, 11203, United States
Brookdale University Hospital and Medical Center
Brooklyn, New York, 11212, United States
Maimonides Medical Center
Brooklyn, New York, 11219, United States
Roswell Park Cancer Institute
Buffalo, New York, 14263-0001, United States
North Shore University Hospital
Manhasset, New York, 11030, United States
Schneider Children's Hospital
New Hyde Park, New York, 11042, United States
New York Presbyterian Hospital - Cornell Campus
New York, New York, 10021-4885, United States
Memorial Sloan-Kettering Cancer Center
New York, New York, 10021, United States
Mount Sinai School of Medicine
New York, New York, 10029, United States
Columbia Presbyterian Hospital
New York, New York, 10032, United States
James P. Wilmot Cancer Center
Rochester, New York, 14642, United States
State University of New York Health Sciences Center - Stony Brook
Stony Brook, New York, 11790-7775, United States
State University of New York - Upstate Medical University
Syracuse, New York, 13210, United States
Albert Einstein Clinical Cancer Center
The Bronx, New York, 10461, United States
New York Medical College
Valhalla, New York, 10595, United States
Mission Saint Joseph's Health System
Asheville, North Carolina, 28801, United States
Lineberger Comprehensive Cancer Center, UNC
Chapel Hill, North Carolina, 27599-7295, United States
Carolinas Medical Center
Charlotte, North Carolina, 28232-2861, United States
Presbyterian Healthcare
Charlotte, North Carolina, 28233-3549, United States
Duke Comprehensive Cancer Center
Durham, North Carolina, 27710, United States
East Carolina University School of Medicine
Greenville, North Carolina, 27858-4354, United States
Comprehensive Cancer Center at Wake Forest University
Winston-Salem, North Carolina, 27157-1081, United States
Dakota Cancer Institute
Fargo, North Dakota, 58103-4940, United States
Children's Hospital Medical Center of Akron
Akron, Ohio, 44308, United States
Children's Hospital Medical Center - Cincinnati
Cincinnati, Ohio, 45229-3039, United States
Ireland Cancer Center
Cleveland, Ohio, 44106-5065, United States
Cleveland Clinic Taussig Cancer Center
Cleveland, Ohio, 44195, United States
Children's Hospital of Columbus
Columbus, Ohio, 43205-2696, United States
Children's Medical Center - Dayton
Dayton, Ohio, 45404, United States
Toledo Children's Hospital
Toledo, Ohio, 43601, United States
St. Vincent Mercy Medical Center
Toledo, Ohio, 43608, United States
Forum Health-Tod Childrens Hospital
Youngstown, Ohio, 44501, United States
Children's Hospital of Oklahoma
Oklahoma City, Oklahoma, 73104, United States
CCOP - Oklahoma
Tulsa, Oklahoma, 74136, United States
Natalie Warren Bryant Cancer Center
Tulsa, Oklahoma, 74136, United States
Doernbecher Children's Hospital
Portland, Oregon, 97201-3098, United States
Legacy Emanuel Hospital and Health Center
Portland, Oregon, 97227, United States
Geisinger Medical Center
Danville, Pennsylvania, 17822-1320, United States
Milton S. Hershey Medical Center
Hershey, Pennsylvania, 17033-0850, United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, 19104, United States
St. Christopher's Hospital for Children
Philadelphia, Pennsylvania, 19134-1095, United States
Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, 15213, United States
Rhode Island Hospital
Providence, Rhode Island, 02818, United States
Medical University of South Carolina
Charleston, South Carolina, 29425-0721, United States
Palmetto Health South Carolina Cancer Center
Columbia, South Carolina, 29203, United States
Children's Hospital of Greenville Hospital System
Greenville, South Carolina, 29605, United States
Avera Cancer Institute
Sioux Falls, South Dakota, 57105-1080, United States
Sioux Valley Hospital
Sioux Falls, South Dakota, 57117, United States
East Tennessee State University Cancer Center at JCMC
Johnson City, Tennessee, 37604, United States
East Tennessee Children's Hospital
Knoxville, Tennessee, 37901, United States
Saint Jude Children's Research Hospital
Memphis, Tennessee, 38105-2794, United States
Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, 37232-6838, United States
Texas Tech University Health Sciences Center School of Medicine
Amarillo, Texas, 79106, United States
Children's Hospital of Austin
Austin, Texas, 78701, United States
Medical City Dallas Hospital
Dallas, Texas, 75230, United States
Simmons Cancer Center - Dallas
Dallas, Texas, 75235-9154, United States
Cook Children's Medical Center - Fort Worth
Fort Worth, Texas, 76104, United States
University of Texas Medical Branch
Galveston, Texas, 77555-0361, United States
University of Texas - MD Anderson Cancer Center
Houston, Texas, 77030-4009, United States
Baylor College of Medicine
Houston, Texas, 77030, United States
San Antonio Military Pediatric Cancer and Blood Disorders Center
Lackland Air Force Base, Texas, 78236-5300, United States
Covenant Children's Hospital
Lubbock, Texas, 79410, United States
University of Texas Health Science Center at San Antonio
San Antonio, Texas, 78207, United States
Methodist Health Care System
San Antonio, Texas, 78229-3902, United States
Scott and White Memorial Hospital
Temple, Texas, 76508, United States
Huntsman Cancer Institute
Salt Lake City, Utah, 84112, United States
Vermont Cancer Center
Burlington, Vermont, 05401-3498, United States
Cancer Center at the University of Virginia
Charlottesville, Virginia, 22908, United States
Inova Fairfax Hospital
Falls Church, Virginia, 22042-3300, United States
Children's Hospital of the King's Daughters
Norfolk, Virginia, 23507, United States
Naval Medical Center, Portsmouth
Portsmouth, Virginia, 23708-5100, United States
Massey Cancer Center
Richmond, Virginia, 23298-0037, United States
Carilion Medical Center for Children
Roanoke, Virginia, 24013, United States
Children's Hospital and Regional Medical Center - Seattle
Seattle, Washington, 98105, United States
Fred Hutchinson Cancer Research Center
Seattle, Washington, 98109-1024, United States
Group Health Cooperative
Seattle, Washington, 98112, United States
Deaconess Medical Center
Spokane, Washington, 99210-0248, United States
Mary Bridge Children's Health Center
Tacoma, Washington, 98415-0299, United States
Madigan Army Medical Center
Tacoma, Washington, 98431-5000, United States
West Virginia University - Charleston
Charleston, West Virginia, 25302, United States
Cabell-Huntington Hospital, Inc
Huntington, West Virginia, 25701, United States
West Virginia University Hospitals
Morgantown, West Virginia, 26506-9300, United States
Bellin Memorial Hospital
Green Bay, Wisconsin, 54301, United States
CCOP - St. Vincent Hospital Cancer Center, Green Bay
Green Bay, Wisconsin, 54301, United States
St. Vincent Hospital
Green Bay, Wisconsin, 54307-9070, United States
Gundersen Lutheran Medical Center
La Crosse, Wisconsin, 54601, United States
University of Wisconsin Hospital and Clinics
Madison, Wisconsin, 53792-0001, United States
Marshfield Clinic
Marshfield, Wisconsin, 54449-5772, United States
Midwest Children's Cancer Center
Milwaukee, Wisconsin, 53226, United States
Sydney Children's Hospital
Randwick, New South Wales, 2031, Australia
Children's Hospital at Westmead
Westmead, New South Wales, 2145, Australia
Royal Children's Hospital
Brisbane, Queensland, 4029, Australia
Women's and Children's Hospital
North Adelaide, South Australia, 5006, Australia
Royal Children's Hospital
Parkville, Victoria, 3052, Australia
Princess Margaret Hospital for Children
Perth, Western Australia, 6001, Australia
Alberta Children's Hospital
Calgary, Alberta, T2T 5C7, Canada
Cross Cancer Institute
Edmonton, Alberta, T6G 1Z2, Canada
British Columbia Children's Hospital
Vancouver, British Columbia, V6H 3V4, Canada
CancerCare Manitoba
Winnipeg, Manitoba, R3E 0V9, Canada
Janeway Children's Health and Rehabilitation Centre
St. John's, Newfoundland and Labrador, A1B 3V6, Canada
IWK Health Centre
Halifax, Nova Scotia, B3J 3G9, Canada
Children's Hospital
Hamilton, Ontario, L8N 3Z5, Canada
Children's Hospital of Western Ontario
London, Ontario, N6C 2V5, Canada
Children's Hospital of Eastern Ontario
Ottawa, Ontario, K1H 8L1, Canada
Hospital for Sick Children
Toronto, Ontario, M5G 1X8, Canada
McGill University Health Center - Montreal Children's Hospital
Montreal, Quebec, H3H 1P3, Canada
Hopital Sainte Justine
Montreal, Quebec, H3T 1C5, Canada
Laval University Medical Center
Sainte-Foy, Quebec, G1V 4G2, Canada
Centre Hospitalier de L'Universite Laval
Sainte-Foy, Quebec, GIV 4G2, Canada
Allan Blair Cancer Centre
Regina, Saskatchewan, S4T 7T1, Canada
Saskatoon Cancer Centre
Saskatoon, Saskatchewan, S7N 4H4, Canada
Academisch Ziekenhuis Groningen
Groningen, 9700 RB, Netherlands
Starship Children's Hospital
Auckland, New Zealand
University of Puerto Rico School of Medicine Medical Sciences Campus
San Juan, 00936-5067, Puerto Rico
San Jorge Childrens Hospital
Santurce, 00912, Puerto Rico
Swiss Pediatric Oncology Group Bern
Bern, CH 3010, Switzerland
Swiss Pediatric Oncology Group Geneva
Geneva, CH 1211, Switzerland
Swiss Pediatric Oncology Group Lausanne
Lausanne, CH 1011, Switzerland
Related Publications (22)
Grundy PE, Green DM, Dirks AC, Berendt AE, Breslow NE, Anderson JR, Dome JS. Clinical significance of pulmonary nodules detected by CT and Not CXR in patients treated for favorable histology Wilms tumor on national Wilms tumor studies-4 and -5: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2012 Oct;59(4):631-5. doi: 10.1002/pbc.24123. Epub 2012 Mar 15.
PMID: 22422736BACKGROUNDKieran K, Anderson JR, Dome JS, Ehrlich PF, Ritchey ML, Shamberger RC, Perlman EJ, Green DM, Davidoff AM. Lymph node involvement in Wilms tumor: results from National Wilms Tumor Studies 4 and 5. J Pediatr Surg. 2012 Apr;47(4):700-6. doi: 10.1016/j.jpedsurg.2011.08.017.
PMID: 22498384BACKGROUNDLange J, Peterson SM, Takashima JR, Grigoriev Y, Ritchey ML, Shamberger RC, Beckwith JB, Perlman E, Green DM, Breslow NE. Risk factors for end stage renal disease in non-WT1-syndromic Wilms tumor. J Urol. 2011 Aug;186(2):378-86. doi: 10.1016/j.juro.2011.03.110. Epub 2011 Jun 17.
PMID: 21683387BACKGROUNDKalapurakal JA, Green DM, Haase G, Anderson JR, Dome JS, Grundy PE. Outcomes of children with favorable histology wilms tumor and peritoneal implants treated in National Wilms Tumor Studies-4 and -5. Int J Radiat Oncol Biol Phys. 2010 Jun 1;77(2):554-8. doi: 10.1016/j.ijrobp.2009.04.081.
PMID: 20457352BACKGROUNDEhrlich PF, Ferrer FA, Ritchey ML, Anderson JR, Green DM, Grundy PE, Dome JS, Kalapurakal JA, Perlman EJ, Shamberger RC. Hepatic metastasis at diagnosis in patients with Wilms tumor is not an independent adverse prognostic factor for stage IV Wilms tumor: a report from the Children's Oncology Group/National Wilms Tumor Study Group. Ann Surg. 2009 Oct;250(4):642-8. doi: 10.1097/SLA.0b013e3181b76f20.
PMID: 19730241BACKGROUNDRitchey M, Daley S, Shamberger RC, Ehrlich P, Hamilton T, Haase G, Sawin R; National Wilms' Tumor Study Group. Ureteral extension in Wilms' tumor: a report from the National Wilms' Tumor Study Group (NWTSG). J Pediatr Surg. 2008 Sep;43(9):1625-9. doi: 10.1016/j.jpedsurg.2008.01.067.
PMID: 18778996BACKGROUNDvan den Heuvel-Eibrink MM, Grundy P, Graf N, Pritchard-Jones K, Bergeron C, Patte C, van Tinteren H, Rey A, Langford C, Anderson JR, de Kraker J. Characteristics and survival of 750 children diagnosed with a renal tumor in the first seven months of life: A collaborative study by the SIOP/GPOH/SFOP, NWTSG, and UKCCSG Wilms tumor study groups. Pediatr Blood Cancer. 2008 Jun;50(6):1130-4. doi: 10.1002/pbc.21389.
PMID: 18095319BACKGROUNDBreslow NE, Beckwith JB, Perlman EJ, Reeve AE. Age distributions, birth weights, nephrogenic rests, and heterogeneity in the pathogenesis of Wilms tumor. Pediatr Blood Cancer. 2006 Sep;47(3):260-7. doi: 10.1002/pbc.20891.
PMID: 16700047BACKGROUNDKalapurakal JA, Nan B, Norkool P, Coppes M, Perlman E, Beckwith B, Ritchey M, Breslow N, Grundy P, D'angio GJ, Green DM, Thomas PR. Treatment outcomes in adults with favorable histologic type Wilms tumor-an update from the National Wilms Tumor Study Group. Int J Radiat Oncol Biol Phys. 2004 Dec 1;60(5):1379-84. doi: 10.1016/j.ijrobp.2004.05.057.
PMID: 15590168BACKGROUNDGadd S, Huff V, Huang CC, Ruteshouser EC, Dome JS, Grundy PE, Breslow N, Jennings L, Green DM, Beckwith JB, Perlman EJ. Clinically relevant subsets identified by gene expression patterns support a revised ontogenic model of Wilms tumor: a Children's Oncology Group Study. Neoplasia. 2012 Aug;14(8):742-56. doi: 10.1593/neo.12714.
PMID: 22952427RESULTPerlman EJ, Grundy PE, Anderson JR, Jennings LJ, Green DM, Dome JS, Shamberger RC, Ruteshouser EC, Huff V. WT1 mutation and 11P15 loss of heterozygosity predict relapse in very low-risk wilms tumors treated with surgery alone: a children's oncology group study. J Clin Oncol. 2011 Feb 20;29(6):698-703. doi: 10.1200/JCO.2010.31.5192. Epub 2010 Dec 28.
PMID: 21189373RESULTFernandez CV, Anderson J, Breslow NE, Dome JS, Grundy PE, Perlman EJ, Green DM; National Wilms Tumor Study Group/Children's Oncology Group. Anthropomorphic measurements and event-free survival in patients with favorable histology Wilms tumor: a report from the Children's Oncology Group. Pediatr Blood Cancer. 2009 Feb;52(2):254-8. doi: 10.1002/pbc.21809.
PMID: 18989885RESULTHuang CC, Gadd S, Breslow N, Cutcliffe C, Sredni ST, Helenowski IB, Dome JS, Grundy PE, Green DM, Fritsch MK, Perlman EJ. Predicting relapse in favorable histology Wilms tumor using gene expression analysis: a report from the Renal Tumor Committee of the Children's Oncology Group. Clin Cancer Res. 2009 Mar 1;15(5):1770-8. doi: 10.1158/1078-0432.CCR-08-1030. Epub 2009 Feb 10.
PMID: 19208794RESULTMalogolowkin M, Cotton CA, Green DM, Breslow NE, Perlman E, Miser J, Ritchey ML, Thomas PR, Grundy PE, D'Angio GJ, Beckwith JB, Shamberger RC, Haase GM, Donaldson M, Weetman R, Coppes MJ, Shearer P, Coccia P, Kletzel M, Macklis R, Tomlinson G, Huff V, Newbury R, Weeks D; National Wilms Tumor Study Group. Treatment of Wilms tumor relapsing after initial treatment with vincristine, actinomycin D, and doxorubicin. A report from the National Wilms Tumor Study Group. Pediatr Blood Cancer. 2008 Feb;50(2):236-41. doi: 10.1002/pbc.21267.
PMID: 17539021RESULTDome JS, Cotton CA, Perlman EJ, Breslow NE, Kalapurakal JA, Ritchey ML, Grundy PE, Malogolowkin M, Beckwith JB, Shamberger RC, Haase GM, Coppes MJ, Coccia P, Kletzel M, Weetman RM, Donaldson M, Macklis RM, Green DM. Treatment of anaplastic histology Wilms' tumor: results from the fifth National Wilms' Tumor Study. J Clin Oncol. 2006 May 20;24(15):2352-8. doi: 10.1200/JCO.2005.04.7852.
PMID: 16710034RESULTEhrlich PF, Hamilton TE, Grundy P, Ritchey M, Haase G, Shamberger RC; National Wilms' Tumor Study Group (National Wilms' Tumor Study 5). The value of surgery in directing therapy for patients with Wilms' tumor with pulmonary disease. A report from the National Wilms' Tumor Study Group (National Wilms' Tumor Study 5). J Pediatr Surg. 2006 Jan;41(1):162-7; discussion 162-7. doi: 10.1016/j.jpedsurg.2005.10.020.
PMID: 16410127RESULTSeibel NL, Sun J, Anderson JR, et al.: Outcome of clear cell sarcoma of the kidney (CCSK) treated on the National Wilms Tumor Study-5 (NWTS). [Abstract] J Clin Oncol 24 (Suppl 18): A-9000, 502s, 2006.
RESULTDome JS, Bockhold CA, Li SM, Baker SD, Green DM, Perlman EJ, Hill DA, Breslow NE. High telomerase RNA expression level is an adverse prognostic factor for favorable-histology Wilms' tumor. J Clin Oncol. 2005 Dec 20;23(36):9138-45. doi: 10.1200/JCO.2005.00.562. Epub 2005 Sep 19.
PMID: 16172460RESULTEhrlich PF, Ritchey ML, Hamilton TE, Haase GM, Ou S, Breslow N, Grundy P, Green D, Norkool P, Becker J, Shamberger RC. Quality assessment for Wilms' tumor: a report from the National Wilms' Tumor Study-5. J Pediatr Surg. 2005 Jan;40(1):208-12; discussion 212-3. doi: 10.1016/j.jpedsurg.2004.09.044.
PMID: 15868587RESULTGrundy PE, Breslow NE, Li S, Perlman E, Beckwith JB, Ritchey ML, Shamberger RC, Haase GM, D'Angio GJ, Donaldson M, Coppes MJ, Malogolowkin M, Shearer P, Thomas PR, Macklis R, Tomlinson G, Huff V, Green DM; National Wilms Tumor Study Group. Loss of heterozygosity for chromosomes 1p and 16q is an adverse prognostic factor in favorable-histology Wilms tumor: a report from the National Wilms Tumor Study Group. J Clin Oncol. 2005 Oct 10;23(29):7312-21. doi: 10.1200/JCO.2005.01.2799. Epub 2005 Aug 29.
PMID: 16129848RESULTMiller MA, Karacay B, Breslow NE, Li S, O'Dorisio MS, Grundy PE, Sandler AD. Prognostic value of quantifying apoptosis factor expression in favorable histology wilms tumors. J Pediatr Hematol Oncol. 2005 Jan;27(1):11-4. doi: 10.1097/01.mph.0000149961.71266.27.
PMID: 15654272RESULTBenedetti DJ, Varela CR, Renfro LA, Tornwall B, Dix DB, Ehrlich PF, Glick RD, Kalapurakal J, Perlman E, Gratias E, Seibel NL, Geller JI, Khanna G, Malogolowkin M, Grundy P, Fernandez CV, Dome JS, Mullen EA. Treatment of children with favorable histology Wilms tumor with extrapulmonary metastases: A report from the COG studies AREN0533 and AREN03B2 and NWTSG study NWTS-5. Cancer. 2024 Mar 15;130(6):947-961. doi: 10.1002/cncr.35099. Epub 2023 Nov 7.
PMID: 37933882DERIVED
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Daniel M. Green, MD
Roswell Park Cancer Institute
Study Design
- Study Type
- interventional
- Phase
- phase 3
- Purpose
- TREATMENT
- Sponsor Type
- NETWORK
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
November 1, 1999
First Posted
January 27, 2003
Study Start
July 1, 1995
Primary Completion
June 1, 2002
Study Completion
August 1, 2003
Last Updated
February 25, 2021
Record last verified: 2014-07