Reliability and Validity of Three DT-TUG Protocols in MS

NCT07788859 | Recruiting

• 1 other identifier: 2026/02-1
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Dual-tasking is performing two different tasks at the same time. For example, singing while cooking. Everyday activities often involve dual-task. In many researches evaluating dual-task performance in individuals with MS, it has been reported that individuals with severe disability, in particular, exhibit greater effort than healthy individuals. This increase in motor and cognitive dual-task performance in individuals with Multiple Sclerosis (MS) is associated with an increased risk of falls. There is a need for standardized, valid, and reliable assessment tools to evaluate dual-task performance in MS. The purpose of this study is to examine and compare the validity and reliability of the dual-task Timed Up and Go test administered using three different protocols.

Conditions

Multiple Sclerosis

Keywords

validity; reliability; dual-task; assessment tools; timed up and go test

Outcome Measures

Primary Outcomes (1)

• Dual-task Timed up and go test (DTUG)

  The DTUG task will be evaluated in three different ways. The primary task will consist of the Timed Up and Go (TUG) test. The TUG test involves standing up from a chair, walking 3 meters, turning around, and sitting back down. While this test is being administered, secondary tasks will be performed simultaneously, and the time taken to complete the test will be recorded. The secondary tasks consist of a three-count backward counting task, verbal fluency, and a ball-carrying task on a tray.

  A single assessment will be administered to all participants at the end of the study. The assessment takes approximately 5 minutes.

Study Arms (1)

Patients with Multiple Sclerosis

Patients with Multiple Sclerosis aged between 18-65 years

Other: Intra-rater reliability analysis; Other: Inter-rater reliability analysis; Other: Convergent validity

Interventions

Intra-rater reliability analysis OTHER

For the intra-rater reliability analysis, three DTUG protocols will be evaluated at 7- to 10-day intervals.

Patients with Multiple Sclerosis

Inter-rater reliability analysis OTHER

For the inter-rater reliability analysis, three DTUG protocols will be administered to the same patient by two different physical therapists.

Patients with Multiple Sclerosis

Convergent validity OTHER

To assess convergent validity, the relationship between the measurements from the three DTUG protocols and the results of other balance and functional mobility tests will be examined.

Patients with Multiple Sclerosis

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Participants will be recruited from among individuals who visit the outpatient clinic of the Department of Neurology at SANKO University.

You may qualify if:

• Having been diagnosed with MS according to the McDonald criteria revised in 2017,
• Being between the ages of 18 and 65,
• Having an Expanded Disability Status Scale (EDSS) score between 0 and 5.5,
• Not requiring any assistive walking devices.

You may not qualify if:

• Pregnancy;
• Having experienced a relapse within the past three months;
• The presence of another neurological condition in addition to MS;
• The presence of a different disorder that could potentially affect gait parameters;
• The presence of visual, auditory, perceptual, or cognitive impairments severe enough to interfere with the test administration

Sponsors & Collaborators

• Afyonkarahisar Health Sciences University: lead

Study Sites (1)

SANKO University

Gaziantep, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Hakan POLAT, PhD

  Sanko University

  STUDY CHAIR

• Meltem UZUN, PhD

  Sanko University

  STUDY CHAIR

• Suat EREL, PhD

  Pamukkale University

  STUDY CHAIR

• Emel TAŞVURAN HORATA, PhD

  Afyonkarahisar Health Sciences University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

EMEL TAŞVURAN HORATA, PhD

CONTACT

05547759663; ethorata@gmail.com

Hakan POLAT, PhD

CONTACT

+905386487265; fzthakanpolat@gmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof.

Study Record Dates

• First Submitted: August 24, 2026
• First Posted: August 27, 2026
• Study Start: March 16, 2026
• Primary Completion (Estimated): September 14, 2026
• Study Completion (Estimated): September 14, 2026
• Last Updated: August 27, 2026

Record last verified: 2026-08

Locations

TU (1)