Effect of Dual-Task Training and Cognitive Rehabilitation in Individuals With Multiple Sclerosis.
Effects of Dual-Task Training and Cognitive Rehabilitation on Gait, Balance, Fatigue and Cognitive Performance in Individuals With Multiple Sclerosis
1 other identifier
interventional
30
1 country
1
Brief Summary
The purpose of this study is to examine the effects of dual-task training and cognitive rehabilitation on gait, balance, fatigue and cognitive performance in individuals with multiple sclerosis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable multiple-sclerosis
Started Apr 2025
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 20, 2025
CompletedFirst Submitted
Initial submission to the registry
April 22, 2025
CompletedFirst Posted
Study publicly available on registry
April 29, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 30, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
June 1, 2026
ExpectedApril 29, 2025
April 1, 2025
2 months
April 22, 2025
April 22, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Dynamic Gait Index (DGI)
DGI is a test that measures the capacity to adapt to changes in walking.It evaluates a total of 8 parameters over 24 points. Values of 19 points and below define the presence of a fall risk.
a year
Secondary Outcomes (5)
Timed 25 Food Walk Test (T25FWT)
a year
The 12-item MS Walking Scale (12-MSWS)
a year
BICAMS (Brief International Cognitive Assessment for MS)
a year
Trial Making Test (TMT)
a year
Modified Fatigue Impact Scale (MFIS)
a year
Study Arms (3)
Dual Task Training Group
EXPERIMENTALThe dual task training group will receive training 2 days a week for 6 weeks. Patients will receive dual task training. They will also receive 30 minutes of individual physiotherapy exercises. 2 days a week. The effects of dual task training and cognitive rehabilitation on gait, balance, fatigue and cognitive performance will be compared.
Cognitive Rehabilitation Group
EXPERIMENTALThe cognitive rehabilitation group will receive training 2 days a week for 6 weeks. Patients will receive cognitive rehabilitation group. They will also receive 30 minutes of individual physiotherapy exercises 2 days a week.
Conventionel Physiotherapy Group
ACTIVE COMPARATORThe conventionel physiotherapy group will receive training 2 days a week for 6 weeks.This group will only receive individual physiotherapy 2 days a week.
Interventions
In dual task training, patients will be given cognitive exercises such as counting backwards from 100 by 3, counting the names of cities, girls and boys while walking.
In cognitive rehabilitation, patients will be given paper-and-pencil activities and exercises to find the difference between two pictures.
In conventionel physiotherapy, patients will be given posture exercises for balance and strengthening.
Eligibility Criteria
You may qualify if:
- Definite MS diagnosis by a neurologist
- Can walk independently
- Expanded Disability Status Scale (EDSS) score below 5
- Has not had an attack in the last 3 months, has been medically stable for 6 months
- Has not received a regular physiotherapy program in the last 6 months volunteer
You may not qualify if:
- Scoring 26 or below on the Montreal Cognitive Assessment Scale (MoCA)
- Having systemic, orthopedic and neurological problems that may affect walking and balance in the assessments
- Having additional psychiatric disorders
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Toros Universitylead
Study Sites (1)
Mersin University
Mersin, 33140, Turkey (Türkiye)
Related Publications (2)
Ozkul C, Guclu-Gunduz A, Eldemir K, Apaydin Y, Gulsen C, Yazici G, Soke F, Irkec C. Dual-Task Cost and Related Clinical Features in Patients With Multiple Sclerosis. Motor Control. 2021 Jan 12;25(2):211-233. doi: 10.1123/mc.2020-0035.
PMID: 33440347BACKGROUNDAbasiyanik Z, Kahraman T. Effect of dual-task training on cognitive functions in persons with multiple sclerosis: A systematic review and meta-analysis. Mult Scler Relat Disord. 2022 Jun;62:103801. doi: 10.1016/j.msard.2022.103801. Epub 2022 Apr 10.
PMID: 35430546RESULT
Related Links
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Aysun Katmerlikaya, MSc
Toros University
- STUDY DIRECTOR
Öznur Tunca, Prof.Dr.
Hacettepe University
- STUDY CHAIR
Serhan Sevim, Prof.Dr.
Mersin University
- STUDY CHAIR
Yeliz Salcı, Assoc.Prof.
Hacettepe University
- STUDY CHAIR
Dilek Hande Esen, PhD
Toros University
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Masking Details
- A randomized, single-blind, controlled trial comparing a dual-task training group, a cognitive rehabilitation group, and a conventional physical therapy group.
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Research Assistant
Study Record Dates
First Submitted
April 22, 2025
First Posted
April 29, 2025
Study Start
April 20, 2025
Primary Completion
June 30, 2025
Study Completion (Estimated)
June 1, 2026
Last Updated
April 29, 2025
Record last verified: 2025-04
Data Sharing
- IPD Sharing
- Will not share