Effects of Dual-Task Training in People With Multiple Sclerosis

NCT05526287 | Completed

• 1 other identifier: MOzkeskin
• Study Type: interventional
• Target: 26
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose of this study is to investigate the effects of dual task training on balance, gait, dual-task performance, cognitive function, fatigue and functional mobility in people with Multiple Sclerosis(MS).

Conditions

Multiple Sclerosis

Keywords

Multiple Sclerosis; Balance; Gait; Dual-Task; Cognitive Function; Functional Mobility; Activities of Daily Living

Outcome Measures

Primary Outcomes (3)

• Berg Balance Scale(BBS)

  BBS, evaluates daily activities including static sitting and standing balance, as well as transfers, turning, and picking up objects from the ground, in 14 items.Scoring is given as 0-4. It scores from 4 (normal performance) to 0 (not able to do the movement) according to the person's ability to do what is asked of them safely and independently. The total score is 56 points. 0-20 indicates high risk, 21-40 indicates medium risk, and 41-64 indicates low risk.

  eight weeks

• Timed Up And Go Test (TUG)

  It is a frequently used test that evaluates functional mobility and dynamic balance. At the beginning of the test, individuals sit in a chair. A distance of 3 m is set in front of the patient. With the start command, the patient gets up from his seat and walks 3 m, turns around and walks back and sits. With the start command, the time until the moment of sitting on the chair is recorded in seconds.Shorter duration indicates better functional mobility.

  eight weeks

• Tetrax((Sunlight Medical Ltd, Israel),Computerized Static Posturography Device

  Tetrax (Sunlight Medical Ltd, Israel) computerized posturography device consists of a platform system where data is collected, a computer and software system where data is processed and integrated. Participants will stand on the platform system in 8 different condition. Tetrax will be used to measure static balance and fall risk.

  eight weeks

Secondary Outcomes (6)

• MS Walking Scale-12(MSWS-12)

  eight weeks

• Fatigue Severity Index(FSI)

  eight weeks

• Brief International Cognitive Assesment for MS(BICAMS)

  eight weeks

• 10 Meter Walking Test(10MWT)

  eight weeks

• Dual-Task Performance

  eight weeks

Study Arms (2)

Dual-Task Group

EXPERIMENTAL

Participants will receive 8 weeks of dual-task training twice a week and home exercise program.Dual-task training will include motor-motor and motor-cognitive dual-task activities.Home exercise program will include core and lower extremity exercises.Home exercises will be performed three times a week.

Other: Dual-Task Training

Control Group

ACTIVE COMPARATOR

Participants will receive 8 weeks of home exercise program.Home exercise program will include core and lower extremity exercises.Home exercises will be performed three times a week.

Other: Home Exercise Program

Interventions

Dual-Task Training OTHER

Dual-task training sessions include; walking on treadmill for 10-30 minutes and half of this walking period participants will perform cognitive tasks, cognitive tasks will be repeated on tandem stance position and single leg stance position other half of the session consists of motor-motor dual task activities and gait training on firm and soft surfaces. Home exercise program includes lower extremity, core stability and balance exercises and will be performed three times a week.

Dual-Task Group

Home Exercise Program OTHER

Home exercise program includes lower extremity, core stability and balance exercises and will be performed three times a week.

Control Group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Having a definitive diagnosis of MS according to the revised McDonald criteria
• Having Expanded Disability Status Scale score between 0-5.5
• No relapse in the last 30 days
• Having a Mini Mental Test score of 24 and above
• Being fluent in Turkish language
• No condition that prevents exercising

You may not qualify if:

• Being pregnant
• Presence of a neuro-musculoskeletal disease other than Multiple Sclerosis
• Having received physiotherapy for balance and gait disorders in the last 3 months

Sponsors & Collaborators

• Ege University: lead

Study Sites (1)

Ege University Faculty of Health Sciences

Izmir, Karsıyaka, 35575, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Nur YUCEYAR, MD

  Ege University

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Professor

Study Record Dates

• First Submitted: July 29, 2022
• First Posted: September 2, 2022
• Study Start: November 1, 2022
• Primary Completion: April 1, 2023
• Study Completion: August 15, 2023
• Last Updated: November 21, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)