The Effect of Online Pilates on Cognitive Function and Dual-Task Performance

NCT06462339 | Completed

• 1 other identifier: MS-Cognition-Onlinepilates
• Study Type: interventional
• Target: 28
• Locations: 1 country
• Sites: 1

Brief Summary

Multiple sclerosis (MS) is a chronic, inflammatory, degenerative disease of the central nervous system, causing demyelination and axonal damage. MS typically begins with attacks resulting from demyelination of axons, eventually evolving into a neurodegenerative disease associated with neurotrophic support deficiency and neuronal loss. Depending on the location and degeneration, various neurological disorders and symptoms such as walking and balance problems, fatigue, sensory loss, and cognitive impairments are observed in MS patients. Cognitive impairments in MS are associated with lesion count, localization, axonal loss, and brain atrophy, affecting approximately 50-60% of patients. Patients exhibit impairments in verbal fluency, visual-spatial memory, processing speed, executive functions, and episodic memory. Cognitive impairments also lead to a decrease in dual-task performance, referred to as the ability to perform two tasks simultaneously, in MS patients. Cognitive problems and impaired dual-task performance negatively impact various aspects of daily life, including social participation and employment status, thus reducing their quality of life. Clinical-based exercise interventions are frequently utilized and effective in improving cognitive functions and dual-task performance in MS. Pilates is a commonly used exercise modality in clinical practice. Pilates is a core stability-based exercise method involving endurance, flexibility, movement, posture, and respiratory control. Previous studies have indicated that clinical Pilates improves cognitive functions. On the other hand, telerehabilitation approaches, the use of which has increased rapidly due to technological developments in recent times, enable the delivery of rehabilitation services to patients in distant places by using communication technologies. For this purpose, it is highly valuable to implement Pilates, which consists of core stability exercise content, through telerehabilitation. While there are studies on clinical-based Pilates interventions, no study has investigated the efficacy of one-on-one online Pilates exercises on cognitive functions and dual-task performance in an online platform. Therefore, this study aims to investigate the effects of online Pilates on cognitive functions and dual-task performance in patients with MS.

Conditions

Multiple Sclerosis

Keywords

Multiple Sclerosis; Cognitive Function; Dual-task; Pilates; Telerehabilitation

Outcome Measures

Primary Outcomes (27)

• Mini-Mental test-Baseline

  Mini Mental Test (MMT) consists of eleven items grouped under five main headings: orientation, recording memory, attention and calculation, recall and language, and is evaluated out of a total score of 30. Accordingly, getting 24 points and above is considered normal.

  Assessment will be conducted before the intervention

• Mini-Mental test-Post intervention

  Mini Mental Test (MMT) consists of eleven items grouped under five main headings: orientation, recording memory, attention and calculation, recall and language, and is evaluated out of a total score of 30. Accordingly, getting 24 points and above is considered normal.

  Assessment will be conducted immediately after the intervention

• Montreal Cognitive Assessment-Baseline

  The Montreal Cognitive Assessment (MoCA) was developed as a rapid screening test for mild cognitive impairment. MoCA evaluates different cognitive functions. These; attention and concentration, executive functions, memory, language, visual structuring skills, abstract thinking, calculation and orientation. The highest total score that can be obtained from the test is 30. Higher scores mean a better outcome.

  Assessment will be conducted before the intervention

• Montreal Cognitive Assessment-Post intervention

  The Montreal Cognitive Assessment (MoCA) was developed as a rapid screening test for mild cognitive impairment. MoCA evaluates different cognitive functions. These; attention and concentration, executive functions, memory, language, visual structuring skills, abstract thinking, calculation and orientation. The highest total score that can be obtained from the test is 30. Higher scores mean a better outcome.

  Assessment will be conducted immediately after the intervention

• Trail Making Test-Baseline

  Trail Making Test (TMT) is used to evaluate individuals' executive functions, task-sequence switching ability, attention, visual scanning speed, visual-motor perception, planning, organization, abstract thinking and reaction limitation. The test consists of 2 parts: A and B. In part A, the individual is asked to combine numbers from 1 to 25 and the completion time is recorded. In part B, the individual completes the sequence corresponding to a number and a letter respectively, and the completion time is recorded.

  Assessment will be conducted before the intervention

• Trail Making Test-Post intervention

  Trail Making Test (TMT) is used to evaluate individuals' executive functions, task-sequence switching ability, attention, visual scanning speed, visual-motor perception, planning, organization, abstract thinking and reaction limitation. The test consists of 2 parts: A and B. In part A, the individual is asked to combine numbers from 1 to 25 and the completion time is recorded. In part B, the individual completes the sequence corresponding to a number and a letter respectively, and the completion time is recorded.

  Assessment will be conducted immediately after the intervention

• Stroop Test-Baseline

  Stroop Test, one of the neuropsychological tests, is used to evaluate selective attention, information processing speed and cognitive flexibility. The test consists of three parts. The first section contains words written in black (e.g. 'blue'), the second section contains colors, and the last section contains words written in different colors (e.g. the word blue written in red ink). The participant is expected to fulfill the tasks in these three sections respectively. While keeping time for each part, the participant must read the words correctly at first, say the colors in the next part, and say the color in which the word is written in the last part. In the test, reading time, number of errors made and number of spontaneous corrections are recorded.

  Assessment will be conducted before the intervention

• Stroop Test-Post intervention

  Stroop Test, one of the neuropsychological tests, is used to evaluate selective attention, information processing speed and cognitive flexibility. The test consists of three parts. The first section contains words written in black (e.g. 'blue'), the second section contains colors, and the last section contains words written in different colors (e.g. the word blue written in red ink). The participant is expected to fulfill the tasks in these three sections respectively. While keeping time for each part, the participant must read the words correctly at first, say the colors in the next part, and say the color in which the word is written in the last part. In the test, reading time, number of errors made and number of spontaneous corrections are recorded.

  Assessment will be conducted immediately after the intervention

• Functional mobility-baseline

  Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again.

  Assessment will be conducted before the intervention

• Dual task performance in functional mobility, Cognitive additional task (arithmetic)-baseline

  Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again. Cognitive additional task (arithmetic): Individuals will be asked to perform tasks by counting backward from 3 to 3 from 100.

  Assessment will be conducted before the intervention

• Dual task performance in functional mobility, Cognitive additional task (verbal)-baseline

  Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again. Cognitive additional task (verbal): Individuals will be asked to fulfill their duties by producing name.

  Assessment will be conducted before the intervention

• functional mobility-post intervention

  Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again.

  Assessment will be conducted immediately after the intervention

• Dual task performance in functional mobility, Cognitive additional task (arithmetic)-post intervention

  Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again. Cognitive additional task (arithmetic): Individuals will be asked to perform tasks by counting backward from 3 to 3 from 100.

  Assessment will be conducted immediately after the intervention

• Dual task performance in functional mobility, Cognitive additional task (verbal)-post intervention

  Timed up and go test measures the time taken in seconds to arise from a standard chair, walk 3 m, turn through 180 degrees, walk back, and sit down again. Cognitive additional task (verbal): Individuals will be asked to fulfill their duties by producing name.

  Assessment will be conducted immediately after the intervention

• balance-baseline

  The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability.

  Assessment will be conducted before the intervention

• balance, Cognitive additional task (arithmetic)-baseline

  The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability. Cognitive additional task (arithmetic)

  Assessment will be conducted before the intervention

• Dual task performance in balance, Cognitive additional task (verbal)-baseline

  The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability. Cognitive additional task (verbal)

  Assessment will be conducted before the intervention

• Dual task performance in balance,Cognitive additional task (arithmetic)-post intervention

  The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability. Cognitive additional task (arithmetic)

  Assessment will be conducted immediately after the intervention

• balance-post intervention

  The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability.

  Assessment will be conducted immediately after the intervention

• Dual task performance in balance,Cognitive additional task (arithmetic) -post intervention

  The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability. Cognitive additional task (arithmetic)

  Assessment will be conducted immediately after the intervention

• Dual task performance in balance,Cognitive additional task (verbal) -post intervention

  The posturography (Biodex Balance System-BioSwayTM) will be used to assess postural stability. Cognitive additional task (verbal)

  Assessment will be conducted immediately after the intervention

• gait-baseline

  Wearable system (G-Walk) will be used to assess gait parameters.

  Assessment will be conducted before the intervention

• Dual task performance in gait, Cognitive additional task (arithmetic)-baseline

  Wearable system (G-Walk) will be used to assess gait parameters. Cognitive additional task (arithmetic)

  Assessment will be conducted before the intervention

• Dual task performance in gait, Cognitive additional task (verbal)-baseline

  Wearable system (G-Walk) will be used to assess gait parameters. Cognitive additional task (verbal)

  Assessment will be conducted before the intervention

• gait-post intervention

  Wearable system (G-Walk) will be used to assess gait parameters.

  Assessment will be conducted immediately after the intervention

• Dual task performance in gait, Cognitive additional task (arithmetic)-post intervention

  Wearable system (G-Walk) will be used to assess gait parameters. Cognitive additional task (arithmetic)

  Assessment will be conducted immediately after the intervention

• Dual task performance in gait, Cognitive additional task (verbal)-post intervention

  Wearable system (G-Walk) will be used to assess gait parameters. Cognitive additional task (verbal)

  Assessment will be conducted immediately after the intervention

Study Arms (2)

Pilates training via telerehabilitation

EXPERIMENTAL

The intervention group will be received online pilates training three times a week for 6 weeks.

Behavioral: Experimental: Intervention Group

Waitlist

NO INTERVENTION

The control group will be a wait-list group without any additional specific treatment.

Interventions

Experimental: Intervention Group BEHAVIORAL

The group that will receive pilates training via telerehabilitation

Pilates training via telerehabilitation

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• years of age
• Voluntarily participate in research to accept
• Having a diagnosis of "Multiple Sclerosis" by a specialist physician
• Relapse free in the last 3 mounts
• An Expanded Disability Status Scale (EDSS) score: 0-5

You may not qualify if:

• Any cardiovascular, orthopedic, visual, hearing, and perception problems that may affect the results of the research
• Having a cardiovascular, pulmonary or hormonal disorder that would prevent exercise
• Having an accompanying neurological disorder other than MS

Sponsors & Collaborators

• Gazi University: lead

Study Sites (1)

Gazi University

Ankara, Turkey (Türkiye)

Location

Related Publications (3)

• Abasiyanik Z, Ertekin O, Kahraman T, Yigit P, Ozakbas S. The effects of Clinical Pilates training on walking, balance, fall risk, respiratory, and cognitive functions in persons with multiple sclerosis: A randomized controlled trial. Explore (NY). 2020 Jan-Feb;16(1):12-20. doi: 10.1016/j.explore.2019.07.010. Epub 2019 Jul 17.

  PMID: 31377306 BACKGROUND

• Ozkul C, Guclu-Gunduz A, Eldemir K, Apaydin Y, Yazici G, Irkec C. Combined exercise training improves cognitive functions in multiple sclerosis patients with cognitive impairment: A single-blinded randomized controlled trial. Mult Scler Relat Disord. 2020 Oct;45:102419. doi: 10.1016/j.msard.2020.102419. Epub 2020 Jul 23.

  PMID: 32736216 BACKGROUND

• Eldemir K, Eldemir S, Ozkul C, Irkec C, Guclu-Gunduz A. The effects of online pilates training on cognitive functions and dual task performance in people with multiple sclerosis: A randomized controlled study. Mult Scler Relat Disord. 2025 May;97:106393. doi: 10.1016/j.msard.2025.106393. Epub 2025 Mar 17.

  PMID: 40120159 DERIVED

MeSH Terms

Conditions

Multiple Sclerosis

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases

Study Officials

• Kader Eldemir, PT, MSc.

  Ordu University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Two groups as exercise group and control group

Study Record Dates

• First Submitted: May 24, 2024
• First Posted: June 17, 2024
• Study Start: June 28, 2024
• Primary Completion: September 12, 2024
• Study Completion: November 12, 2024
• Last Updated: March 18, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)