Relationship Between Single- and Dual-Task Obstacle Crossing Performance and Fatigue and Disability in Multiple Sclerosis

NCT07736482 | Recruiting

• 1 other identifier: 2026/2-122
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This cross-sectional observational study aims to investigate the relationship between obstacle crossing performance under single-task and dual-task conditions and the levels of fatigue and disability in individuals with Relapsing-Remitting Multiple Sclerosis (RRMS). Walking performance will be assessed under standard walking and obstacle crossing conditions with and without a concurrent cognitive task. The study will examine how increased task complexity affects walking performance and its association with fatigue, disability, cognition, and functional mobility.

Conditions

Multiple Sclerosis

Keywords

Multiple sclerosis; Dual Task; Fatigue

Outcome Measures

Primary Outcomes (1)

• Dual-Task Cost During Obstacle Crossing

  Walking performance will be assessed using the 10-Meter Walk Test under four conditions: single-task walking, dual-task walking with serial-3 subtraction, single-task obstacle crossing, and dual-task obstacle crossing with serial-3 subtraction. Walking time and cognitive task performance will be recorded. Dual-Task Cost (DTC, %) will be calculated to quantify the effect of performing a concurrent cognitive task during walking.

  Baseline

Secondary Outcomes (5)

• The Modified Fatigue Impact Scale (MFIS)

  Baseline

• Multiple Sclerosis Walking Scale-12 (MSWS-12)

  Baseline

• Monitoring My Multiple Sclerosis Scale (MMMS)

  Baseline

• Tampa Scale for Kinesiophobia (TSK)

  Baseline

• Fatigue Severity Scale (FSS)

  Baseline

Study Arms (1)

Relapsing-Remitting Multiple Sclerosis

Adults aged 18 to 65 years with a diagnosis of Relapsing-Remitting Multiple Sclerosis (RRMS) according to the 2017 McDonald criteria, an Expanded Disability Status Scale (EDSS) score between 0 and 6, a Montreal Cognitive Assessment (MoCA) score of 26 or higher, and a clinically stable disease course during the previous 6 months. Participants will undergo observational assessments of walking, obstacle crossing performance, fatigue, cognition, functional mobility, and fear of movement. No intervention will be administered.

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adults aged 18 to 65 years with Relapsing-Remitting Multiple Sclerosis who are followed at the Neurology Outpatient Clinic of Kocaeli City Hospital, have an EDSS score between 0 and 6, are clinically stable, and meet all eligibility criteria.

You may qualify if:

• Age between 18 and 65 years.
• Diagnosis of Multiple Sclerosis according to the 2017 McDonald criteria.
• Diagnosis of Relapsing-Remitting Multiple Sclerosis.
• Expanded Disability Status Scale (EDSS) score between 0 and 6.
• Clinically stable disease during the previous 6 months.
• Montreal Cognitive Assessment (MoCA) score of 26 or higher.
• Able to speak and understand Turkish.
• Able to provide written informed consent.

You may not qualify if:

• Multiple sclerosis relapse within the previous month.
• Physician-diagnosed psychiatric disorder.
• Neurological, orthopedic, cardiac, or pulmonary disease other than Multiple Sclerosis that could interfere with study assessments.
• Montreal Cognitive Assessment (MoCA) score below 26.

Sponsors & Collaborators

• Afyonkarahisar Health Sciences University: lead

Study Sites (1)

Afyonkarahisar Health Sciences University

Afyonkarahisar, Merkez, 03000, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Multiple Sclerosis; Fatigue

Condition Hierarchy (Ancestors)

Demyelinating Autoimmune Diseases, CNS; Autoimmune Diseases of the Nervous System; Nervous System Diseases; Demyelinating Diseases; Autoimmune Diseases; Immune System Diseases; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Yunus Emre Kundakcı, Assoc. Prof.

CONTACT

+90 272 246 28 34|; y.emre.kndkc@gmail.com

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assoc. Prof.

Study Record Dates

• First Submitted: July 26, 2026
• First Posted: July 30, 2026
• Study Start: March 20, 2026
• Primary Completion: July 25, 2026
• Study Completion (Estimated): February 20, 2027
• Last Updated: July 31, 2026

Record last verified: 2026-02

Locations

TU (1)