Velocity-Based Resistance Training Effects on Inflammation in Older Adults

NCT07566832 | Not Yet Recruiting

• 1 other identifier: ECKIRB1140803
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to investigate the effects of resistance training (RT) with different training volumes on immune modulation and anti-inflammatory responses in older adults. Participants will be randomly assigned to one of three RT volume groups (low, medium, or high) or a non-exercise control group. Participants in the training groups will complete a 4-week RT program, followed by a 4-week detraining phase. The findings are expected to provide evidence for volume-specific RT prescriptions to support healthy aging.

Conditions

Aging; Inflammatory Response

Outcome Measures

Primary Outcomes (6)

• Changes in IL-6 concentration

  Plasma IL-6 concentrations will be measured and reported in pg/mL.

  Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining

• Changes in soluble IL-6 receptor concentration

  Soluble IL-6 receptor concentrations will be measured and reported in ng/mL.

  Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining

• Changes in soluble gp130 concentration

  Soluble gp130 concentrations will be measured and reported in ng/mL.

  Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining

• Changes in IL-10 concentration

  IL-10 concentrations will be measured and reported in pg/mL.

  Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining

• Changes in IL-1RA concentration

  IL-1RA concentrations will be measured and reported in pg/mL.

  Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining

• Changes in TNF-α concentration

  TNF-α concentrations will be measured and reported in pg/mL.

  Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining

Secondary Outcomes (19)

• Borgs Ratings of Perceived Exertion (RPE)

  1-hour during each exercise intervention

• Handgrip strength

  Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining

• Knee extension strength

  Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining

• 30-second chair-stand test

  Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining

• Single-leg balance test

  Baseline, post-intervention (4 weeks), and at 2 and 4 weeks during detraining

Study Arms (4)

low training volume resistance exercise

EXPERIMENTAL

Participants assigned to the low-volume resistance training group will perform one set per exercise at a load corresponding to 80% of 1RM. Each set will be terminated when movement velocity decreases by 30% from the first repetition. Rest intervals of 2-3 minutes will be provided between exercises.

Other: Resistance exercise

medium training volume resistance exercise

EXPERIMENTAL

Participants assigned to the medium-volume resistance training group will perform three sets per exercise at 80% of 1RM. Each set will be terminated when movement velocity decreases by 30% relative to the first repetition. Rest intervals of 90 seconds will be provided between sets, and 2-3 minutes between exercises.

Other: Resistance exercise

high training volume resistance exercise

EXPERIMENTAL

Participants assigned to the high-volume resistance training group will perform five sets per exercise at 80% of 1RM. Each set will be terminated when movement velocity decreases by 30% relative to the first repetition. Rest intervals of 90 seconds will be provided between sets, and 2-3 minutes between exercises.

Other: Resistance exercise

sedentary control

NO INTERVENTION

Participants in control trial stayed sedentary during the period.

Interventions

Resistance exercise OTHER

The RT program will consist of 12 sessions over a 4-week period, with participants training three times per week and at least one rest day between sessions. All sessions will be supervised by research personnel to ensure proper technique and safety. Exercises will be performed using resistance machines and will include chest press, shoulder press, seated row, lat pulldown, and leg press.

high training volume resistance exercise; low training volume resistance exercise; medium training volume resistance exercise

Eligibility Criteria

• Age: 60 Years - 75 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Aged 60-75 years or older
• No regular resistance training habit (defined as ≥2 sessions per week) in the past year
• No musculoskeletal injuries within the past six months

You may not qualify if:

• Obesity (BMI \> 30 kg/m²), diabetes, hypertension, cancer, heart, kidney, or liver disease, or any other condition that may influence study outcomes.
• Regular use of anti-inflammatory medications (e.g., NSAIDs).
• Smoking or alcohol abuse
• Inability to safely perform the prescribed resistance exercise movements
• Unable to fully comprehend the study information and instructions.

Sponsors & Collaborators

• National Taipei University: lead

Study Sites (1)

National Taiwan Normal University

Taipei, 116, Taiwan

Location

MeSH Terms

Interventions

Resistance Training

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Shun-Hsi Tsai, Ph.D.

  National Taipei University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Shun-Hsi Tsai, Ph.D.

CONTACT

+88686741111; shunhsi@mail.ntpu.edu.tw

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 15, 2026
• First Posted: May 5, 2026
• Study Start: April 1, 2026
• Primary Completion (Estimated): March 1, 2029
• Study Completion (Estimated): December 1, 2029
• Last Updated: May 5, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)