Resistance Training and Cardiometabolic Risk

NCT06054594 | Completed

• 1 other identifier: UQAM-SAP
• Study Type: interventional
• Target: 51
• Locations: 0 countries
• Sites: N/A

Brief Summary

Little is known on the effects of resistance training (RT) alone in individuals with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO). The present study aimed to examine the impact of RT on body composition, physical performance, lipid-lipoprotein profile, inflammation, and glucose-insulin homeostasis in 51 sedentary, postmenopausal women categorized as MHO vs MUHO, according to the Karelis and Rabasa- Lhoret classification or a single-phenotype adiposopathy approach (the plasma adiponectin (A)/leptin (L) ratio). Participants followed a 4-month weekly RT program of 3 non-consecutive days of 6 exercises of major muscle groups (3 sets of 10 repetitions at 80% 1-RM).

Conditions

Metabolic Syndrome

Outcome Measures

Primary Outcomes (1)

• Insulin resistance (IR)

  Homeostasis Model Assessment (HOMA)-IR index = insulin (μUI/mL) x glucose (mmol/L)/22.5

  Baseline and after 4 months

Study Arms (2)

Metabolically healthy obesity (MHO)

EXPERIMENTAL

Healthy/normal metabolic profile

Other: Resistance exercise

Metabolically unhealthy obesity (MUHO)

EXPERIMENTAL

Abnormal metabolic profile

Other: Resistance exercise

Interventions

Resistance exercise OTHER

After baseline testing, participants followed a progressive resistance training program 3 times a week for 4 months.

Metabolically healthy obesity (MHO); Metabolically unhealthy obesity (MUHO)

Eligibility Criteria

• Age: 50 Years - 70 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• cessation of menstruation for more than 1 year and a follicle-stimulating hormone level ≥ 30 IU/L
• sedentary for at least 3 months (\< 2 h/week of structured exercise)
• non-smokers
• free of known inflammatory diseases
• no use of hormone replacement therapy
• body mass index ≥ 30 kg/m2
• low to moderate alcohol consumption (\< 2 drinks/day)

You may not qualify if:

• history of cardiovascular disease
• type 2 diabetes
• orthopedic limitations.

Sponsors & Collaborators

• Université du Québec a Montréal: lead

MeSH Terms

Conditions

Metabolic Syndrome

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Insulin Resistance; Hyperinsulinism; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Antony Karelis, PhD

  Université du Québec a Montréal

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 12, 2023
• First Posted: September 26, 2023
• Study Start: January 1, 2009
• Primary Completion: June 9, 2011
• Study Completion: June 9, 2011
• Last Updated: November 30, 2023

Record last verified: 2023-11

Data Sharing

• IPD Sharing: Will not share