NCT05042167

Brief Summary

Healthy young and older adults will complete two trials in a randomized crossover counter-balanced order, including resistance exercise and sedentary control. During each trial, blood samples will be collected. The investigators hypothesized that an acute bout of resistance exercise exert different inflammation responses in young and older adults.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
16

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started Oct 2021

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

September 2, 2021

Completed
11 days until next milestone

First Posted

Study publicly available on registry

September 13, 2021

Completed
18 days until next milestone

Study Start

First participant enrolled

October 1, 2021

Completed
1.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 31, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2022

Completed
Last Updated

January 13, 2023

Status Verified

January 1, 2023

Enrollment Period

1.2 years

First QC Date

September 2, 2021

Last Update Submit

January 12, 2023

Conditions

AgingInflammatory Response

Outcome Measures

Primary Outcomes (1)

  • Changes in biomarkers of inflammation

    Biomarkers of inflammation will be measured such as IL-10 in pg/mL, IL-6 in pg/mL, TNF-α in pg/mL.

    24-hour during each study intervention

Secondary Outcomes (6)

  • Changes in glucose

    24-hour during each study intervention

  • Changes in metabolic parameters

    24-hour during each study intervention

  • Changes in biomarkers of muscle damage

    24-hour during each study intervention

  • Changes in molecular markers in peripheral blood mononuclear cells (PBMC)

    24-hour during each study intervention

  • Changes in complete blood count (CBC)

    24-hour during each study intervention

  • +1 more secondary outcomes

Study Arms (2)

High-load resistance exercise

EXPERIMENTAL

Subjects in high-load trial performed 3 sets per exercise, 8 repetitions with load of 70%-1RM with 90 sec of rest between sets, followed by a fourth set to voluntary failure.

Other: Resistance exercise

Sedentary control

NO INTERVENTION

Subjects in control trial stayed sedentary during the period.

Interventions

Resistance exerciseOTHER

4 total resistance exercises that target all major muscle groups.

High-load resistance exercise

Eligibility Criteria

Age20 Years - 80 Years
Sexmale(Gender-based eligibility)
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Age: 20-80
  • Healthy male
  • Without experience of resistance training

You may not qualify if:

  • No acute or chronic musculoskeletal symptoms
  • Smoking
  • Alcohol or drug abuse
  • Fail to conduct resistance exercise

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

National Taiwan Normal University

Taipei, 162, Taiwan

Location

Related Publications (1)

  • Tsai SH, Cheng HC, Little JP, Islam H, Liu HW. Elevated Plasma IL-6 Coincides with Activation of STAT3 in PBMC After Acute Resistance Exercise. Med Sci Sports Exerc. 2024 Nov 1;56(11):2117-2124. doi: 10.1249/MSS.0000000000003503.

    PMID: 39475859DERIVED

MeSH Terms

Interventions

Resistance Training

Intervention Hierarchy (Ancestors)

Exercise TherapyRehabilitationAftercareContinuity of Patient CarePatient CareTherapeuticsPhysical Therapy ModalitiesPhysical Conditioning, HumanExerciseMotor ActivityMovementMusculoskeletal Physiological PhenomenaMusculoskeletal and Neural Physiological Phenomena

Study Officials

  • Hung-Wen Liu, Ph.D.

    National Taiwan Normal University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
CROSSOVER
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

September 2, 2021

First Posted

September 13, 2021

Study Start

October 1, 2021

Primary Completion

December 31, 2022

Study Completion

December 31, 2022

Last Updated

January 13, 2023

Record last verified: 2023-01

Data Sharing

IPD Sharing
Will not share

Locations

TW(1)