Assessing the Efficacy of a Muscle Strength Training Intervention for Sarcopenia in Middle-aged and Elderly Individuals

NCT07554274 | Completed

• 1 other identifier: 202403082RINA
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 1

Brief Summary

Taiwan entered an aging society in 2018 and is projected to become a super-aged society by 2025. With the increasing elderly population, age-related diseases have become an urgent issue in modern society. According to 2018 statistics from the Ministry of Health and Welfare, the prevalence of sarcopenia among individuals aged 65 and above in Taiwan is 23.6% in men and 18.6% in women. Sarcopenia is a major contributor to disability in older adults. It is characterized by age-related loss of skeletal muscle mass, decreased muscle strength, and reduced physical performance, which may lead to disability, reduced quality of life, loss of independence, and increased risk of mortality. Previous studies have shown that appropriate nutrition and exercise can delay the onset of sarcopenia and even increase muscle mass, potentially reversing the condition. This study is an extension of the project titled "Assessment of the Intervention Effectiveness of Branched-chain Amino Acids(BCAA) Combined With Medium-chain Fatty Acid(MCFA) Products in Sarcopenia Among Middle-aged and Elderly Individuals". It is an interventional clinical study that recruits middle-aged and older patients with sarcopenia or pre-sarcopenia, using resistance training as the intervention. The results will be compared with the two original groups from the previous study to evaluate whether there are differences in intervention outcomes between resistance training and nutritional supplementation.

Conditions

Sarcopenia

Keywords

sarcopenia; Resistance exercise; Strength training

Outcome Measures

Primary Outcomes (3)

• the scale of sarcopenia

  muscle mass: this study utilizes BIA or DXA to measure the ASMI (measuring limb muscle mass divided by height squared, kg/m\^2)

  Baseline, 8 weeks

• the scale of sarcopenia

  muscle strength: Use a handgrip dynamometer to measure the dominant hand grip strength (kgw) of the participants. Take the maximum value of three measurements, with a one-minute interval between each measurement.

  Baseline, 8 weeks

• the scale of sarcopenia

  physical performance: During testing, participants are required to cross their arms across their chests and record the time (seconds) taken to perform five consecutive sit-to-stand movements and their walking speed (m/s) over a distance of 6 meters.

  Baseline, 8 weeks

Study Arms (1)

Exercise Comparator: will be provided exercise videos for resistance training

OTHER

will be provided with educational materials and exercise videos for resistance training, and will be encouraged to follow instructions and exercise at least twice per week. Weekly phone follow-ups will be conducted to monitor adherence and home exercise performance.

Behavioral: Resistance exercise

Interventions

Resistance exercise BEHAVIORAL

Participants will be provided with educational materials and exercise videos for resistance training, and will be encouraged to follow instructions and exercise at least twice per week. Weekly phone follow-ups will be conducted to monitor adherence and home exercise performance.

Exercise Comparator: will be provided exercise videos for resistance training

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age ≥ 50 years
• Diagnosis of sarcopenia or pre-sarcopenia

You may not qualify if:

• Lack of willingness to participate
• Complete dependence on activities of daily living
• Diagnosis of cancer
• Physician-determined life expectancy of less than two years
• Deemed incapable of undergoing assessment by a physician or clinical assessor

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Study Sites (1)

Department of Geriatrics and Gerontology, National Taiwan University Hospital

Taipei, 100, Taiwan

Location

MeSH Terms

Conditions

Sarcopenia

Interventions

Resistance Training

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Ding-cheng Chan

  Department of Geriatrics and Gerontology, National Taiwan University Hospital

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: HEALTH SERVICES RESEARCH
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 1, 2026
• First Posted: April 28, 2026
• Study Start: July 1, 2024
• Primary Completion: September 4, 2024
• Study Completion: August 31, 2025
• Last Updated: April 28, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

TW (1)