Serum Lipoprotein-a as a Marker of Severity of Coronary Artery Disease in Aortic Valve Sclerosis Patients

NCT07209631 | Completed

• 1 other identifier: Soh-Med-24-09-5PD
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

This work aimed to evaluate the association of serum level of Lp(a) with the severity of coronary artery disease (CAD) in aortic valve sclerosis (AVS) patients.

Conditions

Serum; Lipoprotein(A); Severity; Coronary Artery Disease; Aortic Valve Sclerosis

Outcome Measures

Primary Outcomes (1)

• Incidence of significance of coronary lesions

  Incidence of significance of coronary lesions in relation to lipoprotein (a) level was recorded.

  1 month post-procedure

Study Arms (1)

Study group

Patients with chest pain and/or dyspnea were diagnosed provisionally as having coronary artery disease.

Other: Serum Lipoprotein-a level

Interventions

Serum Lipoprotein-a level OTHER

A venous blood sample was taken from each patient a month or so after discharge to check their Lp (a) levels. The samples were centrifuged for 10 minutes at 2-8 °C, after which the serum was divided into aliquots and stored at -20 ° C.

Study group

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This prospective cohort study was carried out on 100 patients. The study was done after approval from the local Ethics Committee (Under the Declaration of Helsinki). Informed written consent was obtained from the patients.

You may qualify if:

• Age ≥ 18 years.
• Both sexes.
• Patients with chest pain and/or dyspnea were diagnosed provisionally as having coronary artery disease.

You may not qualify if:

• Aortic stenosis.
• Aortic prosthesis.
• Untreated hypothyroidism.
• Severe chronic kidney failure.
• Administration of anti-inflammatory or immunosuppressive drugs.
• Pregnancy.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag University

Sohag, 82511, Egypt

Location

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Cardiovascular, Faculty of Medicine, Sohag University, Sohag, Egypt.

Study Record Dates

• First Submitted: September 29, 2025
• First Posted: October 7, 2025
• Study Start: October 1, 2024
• Primary Completion: May 1, 2025
• Study Completion: May 1, 2025
• Last Updated: October 7, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)