Association Between Gastroesophageal Reflux Disease (GERD) Severity and Dental Caries

NCT07108751 | Completed

• 1 other identifier: 36264PR1280/7/25
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to assess the relationship between gastroesophageal reflux disease (GERD) severity (based on upper gastrointestinal endoscopy) and dental caries severity.

Conditions

Gastroesophageal Reflux Disease; Severity; Dental Caries

Outcome Measures

Primary Outcomes (1)

• Decayed, Missing, and Filled Teeth (DMFT) Index

  The Decayed, Missing, and Filled Teeth (DMFT) Index was calculated as the sum of decayed, missing, and filled teeth, with scores ranging from 0 to 28 or 32, depending on the total number of teeth present.

  3 months post-procedure

Secondary Outcomes (3)

• Basic Erosive Wear Examination Index

  3 months post-procedure

• Plaque Index

  3 months post-procedure

• Salivary analysis

  3 months post-procedure

Study Arms (2)

Study group

Gastroesophageal reflux disease (GERD) patients.

Device: Endoscopy

Control group

Matched control group.

Device: Endoscopy

Interventions

Endoscopy DEVICE

Endoscopy will be performed to all patient

Control group; Study group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

A cross-sectional analytical study was conducted at the Gastrointestinal Endoscopy Unit of the Internal Medicine Department at Tanta University Hospital in Egypt, and the Outpatient Dental Clinic affiliated with Zarqa University Dental Clinics in Jordan between January and June 2025.

You may qualify if:

• Age 18-65 years.
• Both sexes.
• Diagnosed with Gastroesophageal Reflux Disease (GERD) by endoscopy.
• Consent to participate.

You may not qualify if:

• Xerostomia-related disorders.
• Recent antibiotics (last 4 weeks).
• Head/neck radiation history.
• Cognitive impairment affecting consent.
• Pregnant or lactating women.
• HbA1c above 6.4%.

Sponsors & Collaborators

• Tanta University: lead

Study Sites (1)

Tanta University

Tanta, El-Gharbia, 31527, Egypt

Location

MeSH Terms

Conditions

Gastroesophageal Reflux; Dental Caries

Interventions

Endoscopy

Condition Hierarchy (Ancestors)

Esophageal Motility Disorders; Deglutition Disorders; Esophageal Diseases; Gastrointestinal Diseases; Digestive System Diseases; Tooth Demineralization; Tooth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Diagnostic Techniques, Surgical; Diagnostic Techniques and Procedures; Diagnosis; Minimally Invasive Surgical Procedures; Surgical Procedures, Operative

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Internal Medicine, Faculty of Medicine, Tanta University, Tanta, Egypt.

Study Record Dates

• First Submitted: July 31, 2025
• First Posted: August 7, 2025
• Study Start: January 1, 2025
• Primary Completion: June 1, 2025
• Study Completion: June 1, 2025
• Last Updated: August 7, 2025

Record last verified: 2025-07

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)