Prognostic Nutritional Index for Predicting Outcomes Following Coronary Artery Bypass Grafting (CABG) Surgery

NCT07356219 | Active Not Recruiting

• 1 other identifier: RC 6.11.2025
• Study Type: observational
• Target: 117
• Locations: 1 country
• Sites: 1

Brief Summary

Coronary artery bypass grafting (CABG) is a major cardiac surgery associated with risks of serious perioperative complications and mortality. Malnutrition and inflammation are known independent risk factors for poor outcomes in patients with coronary artery disease. This retrospective observational study evaluates the Prognostic Nutritional Index (PNI)-a simple score derived from serum albumin and lymphocyte counts-as an objective measure of nutritional and inflammatory status. The research aims to determine how well preoperative PNI and its postoperative changes can predict complications such as acute kidney injury, myocardial infarction, and sternal wound infections in patients undergoing CABG.

Conditions

Coronary Artery Disease

Outcome Measures

Primary Outcomes (1)

• Diagnostic Accuracy of the Prognostic Nutritional Index (PNI) in Predicting Post-CABG Complications.

  The Area Under the Receiver Operating Characteristic (ROC) Curve (AUC) used to determine the performance of the PNI score in predicting the occurrence of major postoperative complications.

  Approximately 30 days (From surgery through the duration of the hospital/ICU stay.)

Study Arms (1)

CABG Patient Cohort.

Patients who underwent Coronary Artery Bypass Grafting surgery at Benha University Hospital over the preceding five years.

Diagnostic Test: Prognostic Nutritional Index (PNI); Diagnostic Test: Neutrophil-to-Lymphocyte Ratio (NLR); Diagnostic Test: Body Mass Index (BMI)

Interventions

Prognostic Nutritional Index (PNI) DIAGNOSTIC_TEST

Calculated using serum albumin (g/L) and total peripheral lymphocyte count.

CABG Patient Cohort.

Neutrophil-to-Lymphocyte Ratio (NLR) DIAGNOSTIC_TEST

Calculated from peripheral blood counts.

CABG Patient Cohort.

Body Mass Index (BMI) DIAGNOSTIC_TEST

Calculated from preoperative weight and height.

CABG Patient Cohort.

Eligibility Criteria

• Age: 25 Years - 55 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

The study population consists of adult patients (both male and female) who underwent major coronary artery bypass grafting surgery at the Cardiothoracic Surgery Department of Benha University Hospital within a recent five-year period.

You may qualify if:

• Patients who underwent CABG surgery.
• Availability of a signed informed consent form before surgery.

You may not qualify if:

• Other concurrent cardiac surgeries.
• Presence of malignancy or systemic inflammatory disorders.
• Active infection or autoimmune disorders.
• Maintenance on immunosuppressants.
• Liver disease.
• Files with missing data.

Sponsors & Collaborators

• Benha University: lead

Study Sites (1)

Benha University

Banhā, Al Qalyoubia, 13511, Egypt

Location

MeSH Terms

Conditions

Coronary Artery Disease

Interventions

Body Mass Index

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Intervention Hierarchy (Ancestors)

Body Weights and Measures; Body Constitution; Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Anthropometry; Investigative Techniques; Physiological Phenomena; Biometry; Epidemiologic Measurements; Public Health; Environment and Public Health

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant professor of Cardiothoracic Surgery, Faculty of Medicine, Benha University, Egypt

Study Record Dates

• First Submitted: January 11, 2026
• First Posted: January 21, 2026
• Study Start: November 15, 2025
• Primary Completion: January 11, 2026
• Study Completion: January 20, 2026
• Last Updated: January 21, 2026

Record last verified: 2026-01

Locations

EG (1)