NCT07063628

Brief Summary

Our study specifically will address the value of modified triglyceride glucose indices versus left ventricular speckle tracking in prediction of severity of coronary artery disease assessed by Gensini score.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
508

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Apr 2025

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 30, 2025

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

July 1, 2025

Completed
2 days until next milestone

First Submitted

Initial submission to the registry

July 3, 2025

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

July 3, 2025

Completed
11 days until next milestone

First Posted

Study publicly available on registry

July 14, 2025

Completed
Last Updated

July 16, 2025

Status Verified

July 1, 2025

Enrollment Period

2 months

First QC Date

July 3, 2025

Last Update Submit

July 12, 2025

Conditions

Coronary Artery Disease

Outcome Measures

Primary Outcomes (3)

  • triglyceride-glucose (TyG) index

    predictive value of the triglyceride-glucose (TyG) index and its modified forms (TyG×BMI, TyG×WC, TyG, ×, W,Ht,R ) with global longitudinal strain (GLS) in assessing coronary artery disease (CAD) severity, as quantified by the Gensini score.

    2 months

  • longitudinal strain (GLS)

    Echocardiography parameter in assessing coronary artery disease (CAD) severity

    2 months

  • Gensini score.

    Score assessing coronary artery disease (CAD) severity

    2 months

Interventions

TyG-derived index.DIAGNOSTIC_TEST

Derived indices included: * Ty,G×B,M,I = TyG index × body mass index * TyG×W,C = TyG index × waist circumference * TyG×WH,tR = TyG index × waist-to-height ratio Quartile-based stratification was applied to each TyG-derived index.

Also known as: TG index
Left Ventricular Speckle TrackingDIAGNOSTIC_TEST

Coronary Angiography and Gensini Scoring: All participants underwent standard diagnostic coronary angiography. CAD was categorized as one-, two-, or three-vessel disease based on the number of vessels with ≥50% stenosis. The severity of CAD was quantified using the Gensini score, which assigns a severity weight to each lesion depending on degree of stenosis and anatomical location. Final scores were calculated by summing weighted values across all coronary segments.

Also known as: Echocardiographic Assessment

Eligibility Criteria

Age38 Years - 80 Years
Sexall
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Two hundred adult patients with chronic stable angina and angiographically confirmed coronary artery disease (CAD) were enrolled.

You may qualify if:

  • diagnosis of CAD with ≥50% stenosis in at least one major coronary artery.

You may not qualify if:

  • Patients with acute coronary syndrome, arrhythmias, previous coronary interventions (PCI or CABG), or inability to undergo echocardiographic assessment.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Rehab Hussein Werida

Damanhūr, Elbehairah, 31527, Egypt

Location

Related Publications (3)

  • Siverio-Morales O, Mora-Fernandez C, Hernandez-Carballo C, Martin-Nunez E, Gonzalez-Luis A, Martin-Olivera A, Navarro-Gonzalez JF, Donate-Correa J. Predictive value of triglyceride-glucose index for the evaluation of coronary artery disease severity and occurrence of major adverse cardiovascular events. Am J Physiol Heart Circ Physiol. 2025 Jan 1;328(1):H14-H20. doi: 10.1152/ajpheart.00684.2024. Epub 2024 Nov 19.

    PMID: 39560964BACKGROUND

  • Lopez-Jaramillo P, Gomez-Arbelaez D, Martinez-Bello D, Abat MEM, Alhabib KF, Avezum A, Barbarash O, Chifamba J, Diaz ML, Gulec S, Ismail N, Iqbal R, Kelishadi R, Khatib R, Lanas F, Levitt NS, Li Y, Mohan V, Mony PK, Poirier P, Rosengren A, Soman B, Wang C, Wang Y, Yeates K, Yusuf R, Yusufali A, Zatonska K, Rangarajan S, Yusuf S. Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): a prospective cohort study. Lancet Healthy Longev. 2023 Jan;4(1):e23-e33. doi: 10.1016/S2666-7568(22)00247-1. Epub 2022 Dec 12.

    PMID: 36521498BACKGROUND

  • Zhao S, Yu S, Chi C, Fan X, Tang J, Ji H, Teliewubai J, Zhang Y, Xu Y. Association between macro- and microvascular damage and the triglyceride glucose index in community-dwelling elderly individuals: the Northern Shanghai Study. Cardiovasc Diabetol. 2019 Jul 25;18(1):95. doi: 10.1186/s12933-019-0898-x.

    PMID: 31345238BACKGROUND

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary DiseaseMyocardial IschemiaHeart DiseasesCardiovascular DiseasesArteriosclerosisArterial Occlusive DiseasesVascular Diseases

Study Officials

  • Eman Elshaikh, Ass. Prof.

    Tanta University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
CASE CONTROL
Time Perspective
CROSS SECTIONAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Associate Professor

Study Record Dates

First Submitted

July 3, 2025

First Posted

July 14, 2025

Study Start

April 30, 2025

Primary Completion

July 1, 2025

Study Completion

July 3, 2025

Last Updated

July 16, 2025

Record last verified: 2025-07

Data Sharing

IPD Sharing
Will not share

Locations

EG(1)