Triglycerides Glucose Index on Angiographic Profiling of Non-Diabetic Premature Coronary Artery Disease Patients

NCT07154186 | Recruiting

• 1 other identifier: Soh-Med-25-5-5PD
• Study Type: observational
• Target: 180
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to evaluate the impact of the triglyceride-glucose (TyG) index on the angiographic profiling of non-diabetic patients with premature coronary artery disease (CAD).

Conditions

Triglycerides Glucose Index; Angiographic Profiling; Non-Diabetic; Premature; Coronary Artery Disease

Outcome Measures

Primary Outcomes (1)

• Incidence of ischemia- driven revascularization

  Incidence of ischemia- driven revascularization will be recorded.

  6 months post-procedure

Secondary Outcomes (4)

• Association between triglyceride-glucose index and single-vessel disease

  6 months post-procedure

• Association between triglyceride-glucose index and two-vessel disease

  6 months post-procedure

• Association between triglyceride-glucose index and three-vessel disease

  6 months post-procedure

• Correlation of the triglyceride-glucose index with traditional cardiovascular risk factor

  6 months post-procedure

Study Arms (2)

Group L

Patients with a low triglyceride-glucose (TyG) index tertile.

Other: Coronary Angiographic Assessment

Group H

Patients with a high triglyceride-glucose (TyG) index tertile.

Other: Coronary Angiographic Assessment

Interventions

Coronary Angiographic Assessment OTHER

Coronary angiographic assessment will be performed for all patients.

Group H; Group L

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This cross-sectional study will be conducted at Sohag University Hospitals, following approval from the institutional ethics committee.

You may qualify if:

• Age ≥18 years old.
• Both sexes.
• Non-diabetic patients \[no history of diabetes, hemoglobin A1C (HbA1C) \< 6.5%, fasting glucose \< 126 mg/dL\].
• Confirmed diagnosis of coronary artery disease (CAD) by coronary angiography.

You may not qualify if:

• Known diabetes mellitus (type 1 or type 2).
• Previous history of coronary revascularization.
• Severe hepatic or renal dysfunction \[alanine transaminase (ALT)/aspartate aminotransferase (AST) ≥ 5× upper limit of normal (ULN), estimated glomerular filtration rate (eGFR)\< 30 mL/min/1.73 m²\].
• Malignant disease, autoimmune disease, or systemic inflammatory disorders.
• Current use of triglyceride-lowering medications.

Sponsors & Collaborators

• Sohag University: lead

Study Sites (1)

Sohag University

Sohag, 82511, Egypt

RECRUITING

MeSH Terms

Conditions

Premature Birth; Coronary Artery Disease

Condition Hierarchy (Ancestors)

Obstetric Labor, Premature; Obstetric Labor Complications; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Central Study Contacts

Remon S Adly, MD

CONTACT

00201221878986; remonsaleh@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Lecturer of Cardiovascular, Faculty of Medicine, Sohag University, Sohag, Egypt.

Study Record Dates

• First Submitted: August 27, 2025
• First Posted: September 4, 2025
• Study Start: September 4, 2025
• Primary Completion: February 1, 2026
• Study Completion: February 1, 2026
• Last Updated: September 5, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)