Premature Coronary Artery Disease and Familial Dyslipidemia in Patients Presenting With Acute Coronary Syndrome

NCT07267312 | Completed

• 1 other identifier: AFHSRMREC/2023/CARDIOLOGY/678
• Study Type: observational
• Target: 2,000
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to explore the relationship between familial hypercholesterolemia and premature coronary artery disease, particularly in the context of acute coronary syndrome, by reviewing current evidence and highlighting the need for improved screening and aggressive lipid-lowering strategies in high-risk populations.

Conditions

Premature; Coronary Artery Disease; Familial Dyslipidemia; Acute Coronary Syndrome

Outcome Measures

Primary Outcomes (2)

• Dyslipidemia pattern in patients with acute coronary syndrome

  Dyslipidemia pattern in patients with acute coronary syndrome was recorded.

  Within 24 hours of hospital admission

• Incidence of familial dyslipidemia among patients with acute coronary syndrome

  Incidence of familial dyslipidemia among patients with acute coronary syndrome was recorded.

  Within 24 hours of hospital admission

Study Arms (2)

Non-premature coronary artery disease

Males aged \<55 years and females aged \<65 years.

Other: Cardiovascular risk assessment

Premature coronary artery disease

Males aged ≥55 years and females aged ≥65 years.

Other: Cardiovascular risk assessment

Interventions

Cardiovascular risk assessment OTHER

Participants underwent a standardized cardiovascular risk assessment that included detailed clinical evaluation, lipid profiling (Total Cholesterol, Low-Density Lipoprotein Cholesterol, High-Density Lipoprotein Cholesterol, and Triglycerides).

Non-premature coronary artery disease; Premature coronary artery disease

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This was a prospective, cross-sectional, observational study conducted at the Department of Cardiology, Prince Khaled Ben Sultan, between December 2021 and March 2025. A total of 2,000 consecutive adult patients admitted with a confirmed diagnosis of coronary artery disease (CAD) were included.

You may qualify if:

• Age ≥18 years at the time of presentation.
• Both sexes.
• Confirmed diagnosis of coronary artery disease (CAD), established by clinical presentation, electrocardiographic findings, elevated cardiac biomarkers, and/or angiographic evidence of ≥50% luminal stenosis in at least one major coronary artery.
• Hospital admission to the participating cardiology department between \[insert study period, e.g., January 2020 and December 2024\] for acute coronary syndrome (ACS), including unstable angina, non-ST-elevation myocardial infarction (NSTEMI), or ST-elevation myocardial infarction (STEMI).
• Availability of complete clinical, laboratory, and echocardiographic data necessary for classification and analysis.

You may not qualify if:

• Incomplete medical records or missing essential laboratory, imaging, or demographic data.
• Secondary causes of dyslipidemia, including uncontrolled hypothyroidism, nephrotic syndrome, chronic liver disease, or use of lipid-altering medications (other than statins) before presentation.
• Previous congenital or structural heart disease, cardiomyopathy, or significant valvular heart disease unrelated to CAD.
• Severe chronic kidney disease (estimated glomerular filtration rate \<30 mL/min/1.73 m²) or patients on dialysis.
• Autoimmune, inflammatory, or systemic diseases known to influence vascular inflammation or lipid metabolism.
• Malignancy or life expectancy \<6 months due to non-cardiac causes.
• Pregnant or lactating women.
• Non-Saudi patients (focusing on Saudi population in southern region).

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

Cairo University

Cairo, 12613, Egypt

Location

MeSH Terms

Conditions

Premature Birth; Coronary Artery Disease; Acute Coronary Syndrome

Condition Hierarchy (Ancestors)

Obstetric Labor, Premature; Obstetric Labor Complications; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Cardiovascular Medicine Department, Cairo University, Cairo, Egypt.

Study Record Dates

• First Submitted: November 25, 2025
• First Posted: December 5, 2025
• Study Start: December 1, 2021
• Primary Completion: March 27, 2025
• Study Completion: March 27, 2025
• Last Updated: December 5, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: After the end of study for one year.
• Access Criteria: The data will be available upon a reasonable request from the corresponding author.

Locations

EG (1)