TyG Index as a Marker to Predict Severity of Coronary Artery Disease

NCT06452121 | Not Yet Recruiting

• 1 other identifier: TyG index and CAD
• Study Type: observational
• Target: 150
• Locations: 0 countries
• Sites: N/A

Brief Summary

Triglyceride glucose (TyG) index is a novel marker, which has been demonstrated to have a high sensitivity and specificity in identifying metabolic syndrome . Previous studies have shown that TyG index is associated with carotid atherosclerosis, coronary artery calcification and high risk of CVD. This study aims to predict severity of CAD using TyG index and its correlation to coronary angiography findings.

Conditions

Coronary Artery Disease

Keywords

triglyceride-glucose index

Outcome Measures

Primary Outcomes (1)

• Predict severity of coronary artery disease change in Triglyceride glucose (TyG) index

  Predict severity of coronary artery disease using Triglyceride glucose (TyG) index and its correlation to coronary angiography findings

  cases during 1 year of the study

Study Arms (2)

Diabetic patients

to know severity of coronary artery disease using Triglyceride glucose (TyG) index in diabetic patients comparing it with non diabetic

Other: triglyceride glucose index

Non diabetic patients

to know severity of coronary artery disease using Triglyceride glucose (TyG) index in non diabetic patients

Other: triglyceride glucose index

Interventions

triglyceride glucose index OTHER

The TyG index was calculated using the following equation: Ln \[TG (mg/dL)×FPG (mg/dL) / 2\]. CAD was referred to as at least one major coronary artery with≥50% stenosis evaluated by CAG

Diabetic patients; Non diabetic patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients above 18 years old presenting with either with ACS undergoing coronary angiography or Ischemic heart disease patients undergoing elective coronary angiography.

You may qualify if:

• Adult patients above 18 years old presenting with either with ACS undergoing coronary angiography or Ischemic heart disease patients undergoing elective coronary angiography.

You may not qualify if:

• Pregnant or lactating women
• Patients with previous intravenous thrombolysis,
• Long -term use of statins or other lipid-regulating drugs
• Myocarditis

Sponsors & Collaborators

• Assiut University: lead

Related Publications (2)

• Geng X, Zhang X, Li X, Zhong C, Hou M. Triglyceride-glucose Index as a Valuable Marker to Predict Severity of Coronary Artery Disease: A Retrospective Cohort Study. Clin Appl Thromb Hemost. 2024 Jan-Dec;30:10760296241234320. doi: 10.1177/10760296241234320.

  PMID: 38444211 BACKGROUND

• Jin JL, Cao YX, Wu LG, You XD, Guo YL, Wu NQ, Zhu CG, Gao Y, Dong QT, Zhang HW, Sun D, Liu G, Dong Q, Li JJ. Triglyceride glucose index for predicting cardiovascular outcomes in patients with coronary artery disease. J Thorac Dis. 2018 Nov;10(11):6137-6146. doi: 10.21037/jtd.2018.10.79.

  PMID: 30622785 BACKGROUND

MeSH Terms

Conditions

Coronary Artery Disease

Condition Hierarchy (Ancestors)

Coronary Disease; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Arteriosclerosis; Arterial Occlusive Diseases; Vascular Diseases

Study Officials

• Fatma M Abdelaziz

  Assiut University

  STUDY CHAIR

Central Study Contacts

Fatma M Abdelaziz

CONTACT

01001881973; fatmamohsen9292@gmail.com

Alaa Abdelmonem

CONTACT

01112732730

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assistant Lecturer

Study Record Dates

• First Submitted: June 5, 2024
• First Posted: June 11, 2024
• Study Start: September 1, 2024
• Primary Completion: September 1, 2025
• Study Completion: September 1, 2025
• Last Updated: August 5, 2024

Record last verified: 2024-08