Invasive and Non-invasive Haemodynamic Assessment of Pulmonary Hypertension in Chronic Kidney Disease Patient

NCT07052968 | Not Yet Recruiting

• 1 other identifier: RHC in PH pts e ckd
• Study Type: observational
• Target: 75
• Locations: 0 countries
• Sites: N/A

Brief Summary

Patients with CKD who suspected to have pulmonary hypertension by echocardiography with high probability, RHC used to confirm the diagnosis, assessment of hemodynamic parameters, differentiate pre and post capillary types of pulmonary hypertension and asses severity of the disease.

Conditions

Pulmonary Hypertension; Chronic Kidney Disease

Outcome Measures

Primary Outcomes (1)

• Diagnosis of pulmonary hypertention in chronic kidney diseaes patients and identify its type and guide management.

  Hemodynamic assessment by echo including (right atrial surface area, right ventricular diameters, tricuspid annular plane systolic excursion ,tricusped regureg Jet velocity, inferior vena cava diameter and inspiratory collapability, estimated pulmonary artery pressure and left ventricular structure and function) and Hemodynamic assessment by RHC to diagnose and identify tyoe of PH according theses parameters a mean pulmonary arterial pressure (mPAP) \>20 mm Hg, pulmonary artery wedge pressure (PAWP) ≤15mmHg and a PVR \> 2WU. Pre-capillary PH ,mPAP \>20 mmHg,PAWP ≤15mmHg,PVR ≥3WU.Isolated post-capillary PH (IpcPH),mPAP \>20 mmHg,PAWP \>15mmHg,PVR \<3WU. Combined pre- and post-capillary PH (CpcPH),mPAP \>20 mmHg,PAWP \>15mmHg,PVR ≥3WU.Descriptive statistics will be done in the form of frequencies, mean and SD then analytic statistics will be done as chi square, independent sample test, correlations and regression tests, paired t-test will be

  One year

Interventions

Echocardiography DEVICE

Echocardiography is the non invasvive interventional assessment and the RHC is the invasive international assessment of the hemodynamics in PH patients with ckd.

Eligibility Criteria

• Age: 18 Years - 80 Years
• Gender Eligibility Details: All genders
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Admitted patients in Internal medicine department, Critical care unit and pulmonary hypertension unit chest department at Assuit University Hospital.

You may qualify if:

• \- All adult (aged 18 years old and older) patients who were diagnosed CKD(The presence of kidney damage or an estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m², persisting for 3 months or more) and suspected to have pulmonary hypertension by clinical feature or by echocardiography with high probability were included in this study.

You may not qualify if:

• Patients under 18 years old
• Patient with chronic chest disease.
• Patient bleeding diathesis and high risk of bleeding.
• Individuals having acute kidney injury.
• Patient developing other PH aetiologies.

Sponsors & Collaborators

• Assiut University: lead

Related Publications (2)

• Jankowich M, Hebel R, Jantz J, Abbasi S, Choudhary G. Multispecialty pulmonary hypertension clinic in the VA. Pulm Circ. 2017 Oct-Dec;7(4):758-767. doi: 10.1177/2045893217726063. Epub 2017 Aug 22.

  PMID: 28770656 BACKGROUND

• Pugh ME, Hemnes AR, Trammell A, Newman JH, Robbins IM. Variability in hemodynamic evaluation of pulmonary hypertension at large referral centers. Pulm Circ. 2014 Dec;4(4):679-84. doi: 10.1086/678514.

  PMID: 25610603 BACKGROUND

MeSH Terms

Conditions

Hypertension, Pulmonary; Renal Insufficiency, Chronic

Interventions

Echocardiography

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Hypertension; Vascular Diseases; Cardiovascular Diseases; Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Cardiac Imaging Techniques; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Ultrasonography; Heart Function Tests; Diagnostic Techniques, Cardiovascular

Central Study Contacts

Randa Ahmed, MD

CONTACT

+201118683728; randasarhan@aun.edu.eg

Alaa Omar, Phd

CONTACT

+20102 365 8355; alaa_omar11@yahoo.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr,

Study Record Dates

• First Submitted: May 17, 2025
• First Posted: July 8, 2025
• Study Start: August 1, 2025
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): July 1, 2026
• Last Updated: July 8, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share