Role of Echocardiography in the Assessment of Right Ventricular Function in the Pediatric Population With Valvular Pulmonary Stenosis.

NCT04960085 | Unknown

• 1 other identifier: echo in RV function
• Study Type: observational
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Correct assessment of right ventricular function by transthoracic echocardiographic examination in pediatric patients with congenital valvular pulmonary stenosis after Percutaneous Balloon Pulmonary Valvuloplasty

Conditions

Right Ventricular Dysfunction

Outcome Measures

Primary Outcomes (1)

• correlation between right ventricular dysfunction and severity of valvular pulmonary stenosis

  tissue Doppler of the right ventricle before and after trans cutaneous pulmonary valvuloplasty

  baseline

Interventions

echocardiography DEVICE

philips IE33

Eligibility Criteria

• Age: 1 Month - 18 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

pediatric patients with valvular pulmonary stenosis who will undergo trans cutaneous pulmonary valvuloplasty

You may qualify if:

• All pediatric patients with congenital valvular pulmonary stenosis attending echocardiographic outpatient clinic of Assuit University children hospital aged from one month to18 years old

You may not qualify if:

• Age less than one month and older than 18 years. Patients with infundibular and supravalvular pulmonary stenosis

Sponsors & Collaborators

• Assiut University: lead

Related Publications (11)

• Pierpont ME, Basson CT, Benson DW Jr, Gelb BD, Giglia TM, Goldmuntz E, McGee G, Sable CA, Srivastava D, Webb CL; American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young. Genetic basis for congenital heart defects: current knowledge: a scientific statement from the American Heart Association Congenital Cardiac Defects Committee, Council on Cardiovascular Disease in the Young: endorsed by the American Academy of Pediatrics. Circulation. 2007 Jun 12;115(23):3015-38. doi: 10.1161/CIRCULATIONAHA.106.183056. Epub 2007 May 22.

  PMID: 17519398 BACKGROUND

• Baumgartner H, Bonhoeffer P, De Groot NM, de Haan F, Deanfield JE, Galie N, Gatzoulis MA, Gohlke-Baerwolf C, Kaemmerer H, Kilner P, Meijboom F, Mulder BJ, Oechslin E, Oliver JM, Serraf A, Szatmari A, Thaulow E, Vouhe PR, Walma E; Task Force on the Management of Grown-up Congenital Heart Disease of the European Society of Cardiology (ESC); Association for European Paediatric Cardiology (AEPC); ESC Committee for Practice Guidelines (CPG). ESC Guidelines for the management of grown-up congenital heart disease (new version 2010). Eur Heart J. 2010 Dec;31(23):2915-57. doi: 10.1093/eurheartj/ehq249. Epub 2010 Aug 27. No abstract available.

  PMID: 20801927 BACKGROUND

• Haddad F, Doyle R, Murphy DJ, Hunt SA. Right ventricular function in cardiovascular disease, part II: pathophysiology, clinical importance, and management of right ventricular failure. Circulation. 2008 Apr 1;117(13):1717-31. doi: 10.1161/CIRCULATIONAHA.107.653584. No abstract available.

  PMID: 18378625 BACKGROUND

• Haddad F, Hunt SA, Rosenthal DN, Murphy DJ. Right ventricular function in cardiovascular disease, part I: Anatomy, physiology, aging, and functional assessment of the right ventricle. Circulation. 2008 Mar 18;117(11):1436-48. doi: 10.1161/CIRCULATIONAHA.107.653576. No abstract available.

  PMID: 18347220 BACKGROUND

• Hornung TS, Bernard EJ, Jaeggi ET, Howman-Giles RB, Celermajer DS, Hawker RE. Myocardial perfusion defects and associated systemic ventricular dysfunction in congenitally corrected transposition of the great arteries. Heart. 1998 Oct;80(4):322-6. doi: 10.1136/hrt.80.4.322.

  PMID: 9875104 BACKGROUND

• Hauser M, Bengel FM, Hager A, Kuehn A, Nekolla SG, Kaemmerer H, Schwaiger M, Hess J. Impaired myocardial blood flow and coronary flow reserve of the anatomical right systemic ventricle in patients with congenitally corrected transposition of the great arteries. Heart. 2003 Oct;89(10):1231-5. doi: 10.1136/heart.89.10.1231.

  PMID: 12975428 BACKGROUND

• Davlouros PA, Niwa K, Webb G, Gatzoulis MA. The right ventricle in congenital heart disease. Heart. 2006 Apr;92 Suppl 1(Suppl 1):i27-38. doi: 10.1136/hrt.2005.077438.

  PMID: 16543599 BACKGROUND

• Cheung MM, Smallhorn JF, Redington AN, Vogel M. The effects of changes in loading conditions and modulation of inotropic state on the myocardial performance index: comparison with conductance catheter measurements. Eur Heart J. 2004 Dec;25(24):2238-42. doi: 10.1016/j.ehj.2004.07.034.

  PMID: 15589642 BACKGROUND

• Vogel M, Sponring J, Cullen S, Deanfield JE, Redington AN. Regional wall motion and abnormalities of electrical depolarization and repolarization in patients after surgical repair of tetralogy of Fallot. Circulation. 2001 Mar 27;103(12):1669-73. doi: 10.1161/01.cir.103.12.1669.

  PMID: 11273995 BACKGROUND

• Vogel M, Schmidt MR, Kristiansen SB, Cheung M, White PA, Sorensen K, Redington AN. Validation of myocardial acceleration during isovolumic contraction as a novel noninvasive index of right ventricular contractility: comparison with ventricular pressure-volume relations in an animal model. Circulation. 2002 Apr 9;105(14):1693-9. doi: 10.1161/01.cir.0000013773.67850.ba.

  PMID: 11940549 BACKGROUND

• Vogel M, Derrick G, White PA, Cullen S, Aichner H, Deanfield J, Redington AN. Systemic ventricular function in patients with transposition of the great arteries after atrial repair: a tissue Doppler and conductance catheter study. J Am Coll Cardiol. 2004 Jan 7;43(1):100-6. doi: 10.1016/j.jacc.2003.06.018.

  PMID: 14715190 BACKGROUND

MeSH Terms

Conditions

Ventricular Dysfunction, Right

Interventions

Echocardiography

Condition Hierarchy (Ancestors)

Ventricular Dysfunction; Heart Diseases; Cardiovascular Diseases

Intervention Hierarchy (Ancestors)

Cardiac Imaging Techniques; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Ultrasonography; Heart Function Tests; Diagnostic Techniques, Cardiovascular

Central Study Contacts

Saad Abdelhafiz Abdelsalam, master degree

CONTACT

01007459576; saadabdelsalam13@gmail.com

Nagwa Ali Mohamed, prof (MD)

CONTACT

01096260950; Namma65@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Egypt, Assuit

Study Record Dates

• First Submitted: July 2, 2021
• First Posted: July 13, 2021
• Study Start: July 2, 2021
• Primary Completion: July 2, 2022
• Study Completion: August 2, 2022
• Last Updated: July 13, 2021

Record last verified: 2021-07