NCT06677060

Brief Summary

Participants include men and women ≥ 40 years of age with T2DM, established CV disease, a history of HTN with an SBP of at least 130 mmHg at screening, who meet the predefined serum potassium level, and with at least one additional risk factor for HF. The study will include an optional pre-screening period to facilitate sites' identification of potentially eligible participants to enter the full screening assessments. Participants will not be required to visit the site and no informed consent is required for the optional pre-screening period. The pre-screening assessments do not replace the full screening tests at Visit 1. Upon entering the screening period, all consented participants (after signature of screening ICF) will be screened during an up to 14-day screening period. Participants who meet all screening inclusion/exclusion criteria but are not treated with SGLT2i or are treated for less than 4 weeks will enter a run-in period with dapagliflozin 10 mg once daily for at least 4 weeks (and not more than 6 weeks) before randomisation. Site visits will take place at approximately 2-, 4-, 8-, 16-, and 34-weeks following randomisation. Thereafter visits will occur approximately every 4 months. The study closure procedures will be initiated when the predetermined number of the first secondary endpoint events (ie, the composite of hospitalisation for HF or CV death) is predicted to have occurred i.e., the PACD. In case of premature discontinuation of the blinded study intervention, participants will remain in the study. Unless a participant meets the dapagliflozin specific discontinuation criteria, they will continue to receive open label dapagliflozin 10 mg. It is important that the scheduled study visits and data collection continue according to the study protocol.

Trial Health

88
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
11,300

participants targeted

Target at P75+ for phase_3 heart-failure

Timeline
43mo left

Started Mar 2025

Longer than P75 for phase_3 heart-failure

Geographic Reach
35 countries

942 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress25%
Mar 2025Dec 2029

First Submitted

Initial submission to the registry

November 5, 2024

Completed
1 day until next milestone

First Posted

Study publicly available on registry

November 6, 2024

Completed
4 months until next milestone

Study Start

First participant enrolled

March 14, 2025

Completed
4.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 17, 2029

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

December 17, 2029

Last Updated

May 18, 2026

Status Verified

May 1, 2026

Enrollment Period

4.8 years

First QC Date

November 5, 2024

Last Update Submit

May 15, 2026

Conditions

Keywords

Heart failure: Baxdrostat; Dapagliflozin; cardiovascular

Outcome Measures

Primary Outcomes (1)

  • To determine if baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of an HF event or CV death

    Time to first occurrence of any of the components of the composite of: * Hospitalisation for HF * HF without hospitalisation * CV death

    Event driven; Up to 38 months

Secondary Outcomes (5)

  • To determine whether baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of hospitalisation for HF or CV death

    Event driven; Up to 38 months

  • To determine whether baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of HF events

    Event driven; Up to 38 months

  • To determine whether baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of CV death

    Event driven; Up to 38 months

  • To determine whether baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of all-cause mortality

    Event driven; Up to 38 months

  • To determine whether baxdrostat/dapagliflozin is superior to placebo/dapagliflozin in reducing the risk of 4-point MACE (CV death, MI, stroke, and hospitalisation for HF)

    Event driven; Up to 38 months

Study Arms (2)

Baxdrostat/Dapagliflozin

EXPERIMENTAL

Participants randomised to the baxdrostat/dapagliflozin arm will initially receive a dose of baxdrostat lower dose and dapagliflozin. For participants that meet the up-titration criteria, baxdrostat may be up-titrated to higher dose.

Drug: Baxdrostat and dapagliflozin

Placebo/Dapagliflozin

EXPERIMENTAL

Patients will receive a dose of dapagliflozin in combination with matching placebo

Other: Placebo and dapagliflozin

Interventions

baxdrostat tablet and dapagliflozin tablet

Also known as: Baxdrostat CIN-107
Baxdrostat/Dapagliflozin

placebo tablet and dapagliflozin tablet

Placebo/Dapagliflozin

Eligibility Criteria

Age40 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Participants of any sex and gender must be ≥ 40 years old at the time of signing the informed consent.
  • Diagnosed with T2DM and requiring treatment
  • Established CV disease (ischaemic heart disease, cerebrovascular disease, peripheral arterial disease)
  • History of HTN and an SBP ≥ 130 mmHg at screening and ≥ 120 mmHg at the Randomisation Visit.
  • At least one additional risk factor for HF:
  • Age ≥ 70 years
  • UACR \> 20 mg/g
  • eGFR \< 60 mL/min/1.73 m2
  • History of polyvascular disease (at least two of: ischaemic heart disease, cerebrovascular disease, and peripheral arterial disease)
  • History of atrial fibrillation or atrial flutter
  • NT-proBNP \> 125 ng/L

You may not qualify if:

  • Previously confirmed diagnosis and treatment of heart failure
  • An eGFR \< 30 mL/min/1.73 m2 at screening
  • Known hyperkalaemia, defined as potassium ≥ 5.5 mmol/L within 3 months prior to screening
  • Type 1 diabetes mellitus or uncontrolled T2DM with HbA1c \> 10.5% (\> 91 mmol/mol) at screening
  • Serum sodium \< 135 mmol/L at screening, determined as per central laboratory assessment
  • Stroke, transient ischaemic cerebral attack, valve implantation or valve replacement, carotid surgery, carotid angioplasty, or cardiac surgery, within 3 months prior to randomisation
  • Myocardial infarction within 3 months prior to randomisation, or within 1 month prior to randomisation when there is no further planned revascularisation
  • Percutaneous coronary intervention within 1 month prior to randomisation
  • Known severe hepatic impairment, defined as Child-Pugh Class C, based on records that confirm documented medical history
  • Documented history of adrenal insufficiency
  • Any dialysis (including for acute kidney injury) within 3 months prior to screening
  • Any acute kidney injury within 3 months prior to screening
  • Prohibited concomitant medications

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (942)

Research Site

Birmingham, Alabama, 35205, United States

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Centreville, Alabama, 35042, United States

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Fairhope, Alabama, 36532, United States

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Huntsville, Alabama, 35801, United States

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Mobile, Alabama, 36608, United States

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Sheffield, Alabama, 35660, United States

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Vestavia Hills, Alabama, 35216, United States

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Anchorage, Alaska, 99508, United States

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Gilbert, Arizona, 85296, United States

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Glendale, Arizona, 85308, United States

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Tempe, Arizona, 85283, United States

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Tucson, Arizona, 85712, United States

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Dublin, California, 94568, United States

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Huntington Beach, California, 92648, United States

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Inglewood, California, 90301, United States

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La Jolla, California, 92037, United States

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Lakewood, California, 90805, United States

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Lincoln, California, 95648, United States

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Loma Linda, California, 92357, United States

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Los Angeles, California, 90035, United States

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Los Angeles, California, 90073, United States

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Sacramento, California, 95841, United States

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San Diego, California, 92120, United States

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San Dimas, California, 91773, United States

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San Francisco, California, 94115, United States

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San Francisco, California, 94121, United States

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Santa Maria, California, 93454, United States

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Sherman Oaks, California, 91403, United States

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Thousand Oaks, California, 91360, United States

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Aurora, Colorado, 80012, United States

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Englewood, Colorado, 80110, United States

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Bridgeport, Connecticut, 06606, United States

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Stamford, Connecticut, 06905, United States

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Waterbury, Connecticut, 06708, United States

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Crystal River, Florida, 34429, United States

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Fort Lauderdale, Florida, 33316, United States

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Fort Myers, Florida, 33912, United States

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Gainesville, Florida, 32608, United States

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Hialeah, Florida, 33012, United States

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Jacksonville, Florida, 32216, United States

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Lakeland, Florida, 33813, United States

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Miami, Florida, 33125, United States

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Miami, Florida, 33135, United States

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Miami, Florida, 33173, United States

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Ocoee, Florida, 34761, United States

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Orlando, Florida, 32822, United States

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Palmetto Bay, Florida, 33157, United States

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Saint Augustine, Florida, 32086, United States

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Albany, Georgia, 31707, United States

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Atlanta, Georgia, 30303, United States

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Canton, Georgia, 30114, United States

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Columbus, Georgia, 31904, United States

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Cordele, Georgia, 31015, United States

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Suwanee, Georgia, 30024, United States

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Tucker, Georgia, 30084, United States

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Woodstock, Georgia, 30189, United States

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Idaho Falls, Idaho, 83404, United States

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Champaign, Illinois, 61822, United States

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Chicago, Illinois, 60616, United States

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Chicago, Illinois, 60621, United States

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Chicago, Illinois, 60631, United States

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Gurnee, Illinois, 60031, United States

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Island Lake, Illinois, 60042, United States

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Park Ridge, Illinois, 60068, United States

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Indianapolis, Indiana, 46202, United States

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Munster, Indiana, 46321, United States

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Richmond, Indiana, 47374, United States

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South Bend, Indiana, 46617, United States

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El Dorado, Kansas, 67042, United States

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Lenexa, Kansas, 66219, United States

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Newton, Kansas, 67114, United States

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Wichita, Kansas, 67218, United States

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Lexington, Kentucky, 40509, United States

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Owensboro, Kentucky, 42301, United States

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Paducah, Kentucky, 42001, United States

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Alexandria, Louisiana, 71303, United States

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Bossier City, Louisiana, 71111, United States

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Shreveport, Louisiana, 71101, United States

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Baltimore, Maryland, 21229, United States

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Beltsville, Maryland, 20705, United States

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Lutherville-Timonium, Maryland, 21093, United States

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Potomac, Maryland, 20854, United States

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Boston, Massachusetts, 02115, United States

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New Bedford, Massachusetts, 02740, United States

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Roslindale, Massachusetts, 02131, United States

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Farmington Hills, Michigan, 48336, United States

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Flint, Michigan, 48532, United States

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Troy, Michigan, 48098, United States

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Ypsilanti, Michigan, 48197, United States

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Mankato, Minnesota, 56001, United States

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Minneapolis, Minnesota, 55417, United States

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Columbia, Missouri, 65201, United States

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Kansas City, Missouri, 64111, United States

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Kansas City, Missouri, 64151, United States

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St Louis, Missouri, 63136, United States

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Kalispell, Montana, 59901, United States

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Missoula, Montana, 59804, United States

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Norfolk, Nebraska, 68701, United States

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Omaha, Nebraska, 68134, United States

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Carson City, Nevada, 89706, United States

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Portsmouth, New Hampshire, 03801, United States

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Eatontown, New Jersey, 07724, United States

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Pennington, New Jersey, 08534, United States

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Somerset, New Jersey, 08873, United States

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Albuquerque, New Mexico, 87102, United States

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Albuquerque, New Mexico, 87108, United States

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Albany, New York, 12208, United States

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Albany, New York, 12211, United States

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Brooklyn, New York, 11201, United States

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Brooklyn, New York, 11220, United States

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Massapequa, New York, 11758, United States

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New York, New York, 10029, United States

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Queens Village, New York, 11428, United States

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Charlotte, North Carolina, 28287, United States

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Durham, North Carolina, 27701, United States

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Fayetteville, North Carolina, 28304, United States

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Kernersville, North Carolina, 27284, United States

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Monroe, North Carolina, 28112, United States

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New Bern, North Carolina, 28562, United States

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Raleigh, North Carolina, 27607, United States

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Rocky Mount, North Carolina, 27804, United States

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Fargo, North Dakota, 58104, United States

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Beavercreek, Ohio, 45431, United States

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Canton, Ohio, 44718, United States

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Cincinnati, Ohio, 45219, United States

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Cincinnati, Ohio, 45220, United States

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Columbus, Ohio, 43215, United States

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Columbus, Ohio, 43228, United States

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Dayton, Ohio, 45424, United States

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Maumee, Ohio, 43537, United States

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Toledo, Ohio, 43606, United States

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Norman, Oklahoma, 73069, United States

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Oklahoma City, Oklahoma, 73111, United States

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Oklahoma City, Oklahoma, 73120, United States

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Medford, Oregon, 97504, United States

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Camp Hill, Pennsylvania, 17011, United States

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Horsham, Pennsylvania, 19044, United States

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Philadelphia, Pennsylvania, 19114, United States

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Scottdale, Pennsylvania, 15683, United States

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Smithfield, Pennsylvania, 15478, United States

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West Chester, Pennsylvania, 19380, United States

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Columbia, South Carolina, 29209, United States

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Fort Mill, South Carolina, 29715, United States

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Greenville, South Carolina, 29615, United States

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Mt. Pleasant, South Carolina, 29464, United States

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North Charleston, South Carolina, 29405, United States

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Spartanburg, South Carolina, 29301, United States

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Cleveland, Tennessee, 37312, United States

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Morristown, Tennessee, 37813, United States

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Nashville, Tennessee, 37203, United States

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Abilene, Texas, 79606, United States

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Austin, Texas, 78704, United States

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Beaumont, Texas, 77702, United States

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Brownsville, Texas, 78526, United States

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Dallas, Texas, 75390-9015, United States

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Duncanville, Texas, 75137, United States

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El Paso, Texas, 79905, United States

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El Paso, Texas, 79935, United States

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Houston, Texas, 77084, United States

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Houston, Texas, 77089, United States

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Lewisville, Texas, 75067, United States

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Mansfield, Texas, 76063, United States

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McAllen, Texas, 78501, United States

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McAllen, Texas, 78503, United States

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Mesquite, Texas, 75149, United States

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Paris, Texas, 75462, United States

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Pearland, Texas, 77584, United States

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San Antonio, Texas, 78231, United States

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San Antonio, Texas, 78257, United States

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Stephenville, Texas, 76401, United States

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Sugar Land, Texas, 77479, United States

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Tomball, Texas, 77375, United States

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Weslaco, Texas, 78596, United States

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Woodway, Texas, 76712, United States

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Clearfield, Utah, 84015, United States

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Ogden, Utah, 84405, United States

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Burlington, Vermont, 05401, United States

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Burke, Virginia, 22015, United States

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Charlottesville, Virginia, 22911, United States

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Fairfax, Virginia, 22033, United States

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Falls Church, Virginia, 22042, United States

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Manassas, Virginia, 20110, United States

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Midlothian, Virginia, 23112, United States

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Norfolk, Virginia, 23502, United States

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Norfolk, Virginia, 23504, United States

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Richmond, Virginia, 23249, United States

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Salem, Virginia, 24153, United States

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Puyallup, Washington, 98372, United States

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Redmond, Washington, 98052, United States

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Renton, Washington, 98057, United States

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Kingwood, West Virginia, 26537, United States

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Morgantown, West Virginia, 26505, United States

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Green Bay, Wisconsin, 54303, United States

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Milwaukee, Wisconsin, 53226, United States

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Buenos Aires, C1425AGC, Argentina

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CABA, C1056ABH, Argentina

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CABA, C1119ACN, Argentina

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CABA, C1120AAC, Argentina

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Caba, C1128AAF, Argentina

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Ciudad de Buenos Aires, C1428DCO, Argentina

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Córdoba, 5000, Argentina

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Córdoba, X5003DCP, Argentina

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La Plata, B1904, Argentina

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Mar del Plata, B7600FZN, Argentina

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Mar del Plata, B7600GNY, Argentina

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Rosario, 2000, Argentina

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Rosario, S2000PBJ, Argentina

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San Nicolás, B2900DMH, Argentina

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San Nicolás de los Arroyos, B2900DPA, Argentina

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San Vicente, 5006, Argentina

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Santa Fe, S3000FWO, Argentina

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Adelaide, 5000, Australia

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Castle Hill, 2154, Australia

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Coffs Harbour, 02450, Australia

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Elizabeth Vale, 5112, Australia

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Fremantle, 6160, Australia

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Geelong, 3220, Australia

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Kingswood, 2747, Australia

TERMINATED

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Leabrook, 5068, Australia

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Maroubra, 2035, Australia

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Merewether, 2291, Australia

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Milton, 4064, Australia

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Mulgrave, 3170, Australia

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Osborne Park, 6017, Australia

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Rockhampton, 4700, Australia

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Wollongong, 2500, Australia

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Belém, 66073-005, Brazil

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Blumenau, 89010-022, Brazil

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Bragança Paulista, 12916-542, Brazil

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Brasília, 71625-009, Brazil

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Campina Grande do Sul, 83.430-000, Brazil

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Campinas, 13060-080, Brazil

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Campinas, 13060-904, Brazil

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Curitiba, 80030-480, Brazil

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Curitiba, 80810-050, Brazil

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Juiz de Fora, 36033-318, Brazil

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Natal, 59020-035, Brazil

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Porto Alegre, 90160-093, Brazil

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Porto Alegre, 9061-000, Brazil

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Porto Alegre, 90630-165, Brazil

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Porto Alegre, 91350-200, Brazil

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Rio de Janeiro, 20241-180, Brazil

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São José do Rio Preto, 15090-000, Brazil

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São José dos Campos, 12230-001, Brazil

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São Paulo, 01228-000, Brazil

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São Paulo, 01236-030, Brazil

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São Paulo, 04012-180, Brazil

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São Paulo, 05403-000, Brazil

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Tatuí, 18270-170, Brazil

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Haskovo, 6300, Bulgaria

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Panagyurishte, 4500, Bulgaria

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Petrich, 2850, Bulgaria

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Pleven, 5800, Bulgaria

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Pleven, 5804, Bulgaria

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Plovdiv, 4003, Bulgaria

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Rousse, 7000, Bulgaria

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Shumen, 9700, Bulgaria

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Sofia, 1000, Bulgaria

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Sofia, 1309, Bulgaria

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Sofia, 1404, Bulgaria

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Sofia, 1431, Bulgaria

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Sofia, 1527, Bulgaria

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Sofia, 1618, Bulgaria

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Sofia, 1680, Bulgaria

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Stara Zagora, 6003, Bulgaria

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Varna, 9000, Bulgaria

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Calgary, Alberta, T2H 2G4, Canada

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Calgary, Alberta, T2V 4J2, Canada

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Sherwood Park, Alberta, T8H 0N2, Canada

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Abbotsford British Columbia, British Columbia, V2S 0C2, Canada

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Moncton, New Brunswick, E1C 2Z3, Canada

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Saint John, New Brunswick, E2L 4L2, Canada

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Research Site

St. John's, Newfoundland and Labrador, A1B 3V6, Canada

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Halifax, Nova Scotia, B3H 1V7, Canada

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Sydney, Nova Scotia, B1P 1P3, Canada

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Cambridge, Ontario, N1R 6V6, Canada

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Guelph, Ontario, N1H 1B1, Canada

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Hamilton, Ontario, L8J 0B6, Canada

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Hamilton, Ontario, L8L 5G4, Canada

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Markham, Ontario, L3S 0A2, Canada

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Newmarket, Ontario, L3Y 2P6, Canada

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North York, Ontario, M6B 3H7, Canada

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North York, Ontario, M9N 1W4, Canada

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Oakville, Ontario, L6K 3W7, Canada

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Ottawa, Ontario, K2J 0V2, Canada

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Sarnia, Ontario, N7T 4X3, Canada

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Scarborough Village, Ontario, M1B 4Z8, Canada

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Toronto, Ontario, M4G 3E8, Canada

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Toronto, Ontario, M5B 1W8, Canada

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Toronto, Ontario, M6G 1M2, Canada

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Laval, Quebec, H7T 2P5, Canada

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Lévis, Quebec, G6V 9H4, Canada

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Mirabel, Quebec, J7J 2K8, Canada

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Montreal, Quebec, H1T 1C8, Canada

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Montreal, Quebec, H4A 3T2, Canada

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Québec, Quebec, G1G 5X1, Canada

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Québec, Quebec, G1V 4G5, Canada

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Saint-Charles-Borromée, Quebec, J6E 6J2, Canada

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Sherbrooke, Quebec, J1H 5N4, Canada

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Terrebonne, Quebec, J6X 4P7, Canada

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Trois-Rivières, Quebec, G9A 4P3, Canada

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Regina, Saskatchewan, S4P 0W5, Canada

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Baotou, 14010, China

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Beijing, 100029, China

WITHDRAWN

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Beijing, 100029, China

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Beijing, 100050, China

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Changchun, 130021, China

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Changchun, 130033, China

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Changde, 415000, China

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Changsha, 410011, China

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Changsha, 410015, China

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Changzhou, 272100, China

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Chengdu, 610000, China

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Chengdu, 610041, China

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Chifeng, 024000, China

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Chongqing, 400014, China

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Chongqing, 400042, China

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Guangzhou, 510100, China

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Guangzhou, 511486, China

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Harbin, 150000, China

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Hefei, 230001, China

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Hengyang, 421001, China

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Heze, 274099, China

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Huangshi, 435000, China

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Huizhou, 516002, China

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Jinan, 250001, China

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Jining, 272006, China

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Kaifeng, 475000, China

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Liaocheng, 252000, China

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Linhai, 317000, China

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Linyi, 276003, China

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Lishui, 323000, China

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Luoyang, 471000, China

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Luoyang, 471001, China

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Meihekou, 135022, China

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Nanchang, 330009, China

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Nanjing, 210008, China

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Nantong, 226001, China

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Nanyang, 473000, China

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Panjin, 124009, China

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Pingxiang, 337055, China

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Sanya, 572000, China

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Shanghai, 200240, China

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Shanghai, 201114, China

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Shenyang, 110016, China

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Siping, 136000, China

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Suzhou, 215004, China

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Taiyuan, 030024, China

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Tianjin, 300000, China

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Wenzhou, 325000, China

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Wuhan, 430010, China

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Wuhan, 430060, China

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Xi'an, 710061, China

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Xi'an, 710068, China

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Xianyang, 750004, China

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Xuzhou, 221009, China

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Yinchuan, 750004, China

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Zhumadian, 463000, China

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Zigong, 643000, China

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Benešov, 256 01, Czechia

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Brandýs nad Labem, 250 01, Czechia

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Brno, 603 00, Czechia

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Brno, 639 00, Czechia

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Broumov, 55001, Czechia

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Chlumec nad Cidlinou, 503 51, Czechia

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Hodonín, 695 01, Czechia

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Humpolec, 396 01, Czechia

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Jílové u Prahy, 254 01, Czechia

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Krnov, 794 01, Czechia

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Olomouc, 772 00, Czechia

COMPLETED

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Ostrava, 702 00, Czechia

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Pilsen, 301 00, Czechia

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Police nad Metují, 549 54, Czechia

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Prague, 101 00, Czechia

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Prague, 104 00, Czechia

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Prague, 12808, Czechia

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Prague, 149 00, Czechia

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Prague, 150 00, Czechia

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Prague, 190 14, Czechia

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Aarhus, 8200, Denmark

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Aarhus N, 8200, Denmark

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Copenhagen, 2300, Denmark

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Esbjerg, 6700, Denmark

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Frederiksberg, 2000, Denmark

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Gistrup, 9260, Denmark

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Herlev, 2730, Denmark

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Herning, 7400, Denmark

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Hillerød, 3400, Denmark

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Hjørring, 9800, Denmark

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Holbæk, 4300, Denmark

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Hvidovre, 2650, Denmark

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Roskilde, 4000, Denmark

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Slagelse, DK-4200, Denmark

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Svendborg, 5700, Denmark

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Viborg, 8800, Denmark

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Amiens, 80054, France

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Angers, 49933, France

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Aurillac, 15002, France

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Besançon, 25030, France

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Bobigny, 93000, France

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Bois-Guillaume, 76230, France

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Brest, 29200, France

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Caen, 14033, France

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Cholet, 49300, France

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Clermont-Ferrand, 63000, France

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Colombes, 92700, France

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Corbeil-Essonnes, 91106, France

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Dijon, 2100, France

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La Roche-sur-Yon, 85925, France

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La Rochelle, 17000, France

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Le Coudray, 28630, France

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Le Creusot, 71206, France

WITHDRAWN

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Lyon, 69007, France

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Marseille, 13385, France

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Montpellier, 34295, France

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Nantes, 44093, France

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Narbonne, 11108, France

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Paris, 75010, France

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Paris, 75018, France

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Paris, 75908, France

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Pierre-Bénite, 69495, France

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Toulouse, 31059, France

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Vandœuvre-lès-Nancy, 54511, France

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Villeurbanne, 69100, France

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Aachen, 52074, Germany

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Amberg, 92224, Germany

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Bad Homburg, 61348, Germany

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Bad Oeynhausen, 32545, Germany

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Bamberg, 96049, Germany

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Bechhofen, 66894, Germany

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Berlin, 10367, Germany

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Berlin, 10789, Germany

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Berlin, 12203, Germany

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Berlin, 13187, Germany

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Berlin, 13353, Germany

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Berlin, 13597, Germany

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Bochum, 44789, Germany

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Bochum, 44869, Germany

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Brandenburg an der Havel, 14770, Germany

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Brandenburg an der Havel, 14776, Germany

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Bremen, 28277, Germany

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Cologne, 51065, Germany

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Cologne, 51069, Germany

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Deggingen, 73326, Germany

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Dresden, 01069, Germany

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Dresden, 01277, Germany

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Elsterwerda, 04910, Germany

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Essen, 45136, Germany

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Essen, 45355, Germany

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Essen, 45355, Germany

WITHDRAWN

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Frankfurt, 60596, Germany

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Freiburg im Breisgau, 79106, Germany

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Friedrichsthal, 66299, Germany

SUSPENDED

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Fulda, 36037, Germany

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Gelnhausen, 63571, Germany

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Görlitz, 02828, Germany

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Hamburg, 21109, Germany

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Hamburg, 22041, Germany

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Hamburg, 22459, Germany

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Hamburg, 22607, Germany

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Haßloch, 67454, Germany

WITHDRAWN

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Heidelberg, 69120, Germany

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Homburg, 66424, Germany

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Kaiserslautern, 67655, Germany

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Kassel, 34121, Germany

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Langen, 63225, Germany

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Leipzig, 04179, Germany

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Leipzig, 04249, Germany

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Leipzig, 04347, Germany

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Ludwigshafen, 67059, Germany

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Ludwigshafen, 67063, Germany

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Mannheim, 68165, Germany

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Markkleeberg, 04416, Germany

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Munich, 80809, Germany

WITHDRAWN

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Münster, 48153, Germany

WITHDRAWN

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Naunhof, 04683, Germany

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Neuruppin, 16816, Germany

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Nittendorf, 93152, Germany

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Obertshausen, 63179, Germany

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Oldenburg, 23758, Germany

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Osnabrück, 49080, Germany

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Papenburg, 26871, Germany

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Pirna, 01796, Germany

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Potsdam, 14473, Germany

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Ratingen, 40882, Germany

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Reinfeld (Holstein), 23858, Germany

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Völklingen, 66333, Germany

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Wallerfing, 94574, Germany

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Wangen, 88239, Germany

WITHDRAWN

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Weinheim, 69469, Germany

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Zwenkau, 04442, Germany

WITHDRAWN

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Athens, 11527, Greece

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Athens, 11528, Greece

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Athens, 12462, Greece

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Athens, 17562, Greece

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Chania, 73300, Greece

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Ioannina, 45110, Greece

RECRUITING

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Ioannina, 45500, Greece

NOT YET RECRUITING

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Larissa, 41110, Greece

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Piraeus, 18454, Greece

RECRUITING

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Piraeus, 18536, Greece

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Thessaloniki, 54636, Greece

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Thessaloniki, 54642, Greece

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Thessaloniki, 57001, Greece

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Balatonfüred, 8230, Hungary

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Balatonfüred, 8230, Hungary

WITHDRAWN

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Békéscsaba, 5600, Hungary

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Budapest, 1033, Hungary

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Budapest, 1036, Hungary

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Budapest, 1083, Hungary

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Budapest, 1102, Hungary

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Budapest, 1106, Hungary

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Budapest, 1122, Hungary

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Budapest, 1148, Hungary

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Debrecen, 4032, Hungary

RECRUITING

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Gyöngyös, 3200, Hungary

WITHDRAWN

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Kalocsa, 6300, Hungary

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Nyíregyháza, 4400, Hungary

WITHDRAWN

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Nyíregyháza, 4400, Hungary

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Nyíregyháza, 4405, Hungary

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Nyíregyháza-Sóstóhegy, 4481, Hungary

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Orosháza, 5900, Hungary

WITHDRAWN

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Pécs, 7623, Hungary

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Pécs, 7635, Hungary

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Szeged, 6724, Hungary

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Székesfehérvár, 8000, Hungary

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Szigetvár, 7900, Hungary

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Szolnok, 5000, Hungary

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Ahmedabad, 380054, India

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Ajmer, 305001, India

WITHDRAWN

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Bangalore, 560069, India

WITHDRAWN

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Belagavi, 590010, India

RECRUITING

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Dehradun, 248001, India

NOT YET RECRUITING

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Delhi, 110062, India

RECRUITING

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Gurgaon, 122001, India

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Hyderabad, 500 034, India

RECRUITING

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Hyderabad, 500018, India

WITHDRAWN

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Hyderabad, 500035, India

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Hyderabad, 500082, India

NOT YET RECRUITING

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Kanpur, 208001, India

RECRUITING

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Karamsad, 388345, India

RECRUITING

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Kolkata, 700014, India

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Kolkata, 700020, India

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Lucknow, 226010, India

WITHDRAWN

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Nagpur, 441108, India

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New Delhi, 100049, India

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New Delhi, 110002, India

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New Delhi, 110017, India

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Secunderabad, 500003, India

NOT YET RECRUITING

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Surat, 395001, India

RECRUITING

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Surat, 396007, India

RECRUITING

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Vijayawada, 520 008, India

RECRUITING

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Beersheba, 8410101, Israel

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Be’er Ya‘aqov, 70300, Israel

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Haifa, 3109601, Israel

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Herzelia, 4640200, Israel

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Holon, 5822012, Israel

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Jerusalem, 91120, Israel

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Petah Tikva, 4941492, Israel

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Ramat Gan, 52621, Israel

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Tel Aviv, 61480, Israel

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Tel Aviv, 6423906, Israel

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Tel Aviv, 64239, Israel

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Alessandria, 15100, Italy

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Bari, 70124, Italy

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Bergamo, 24127, Italy

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Brescia, 25123, Italy

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Chiavari, 16034, Italy

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Cona, 44124, Italy

RECRUITING

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Foggia, 71100, Italy

RECRUITING

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Milan, 20122, Italy

RECRUITING

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Milan, 20132, Italy

RECRUITING

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Milan, 20138, Italy

RECRUITING

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Milan, 20154, Italy

RECRUITING

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Milan, 20162, Italy

RECRUITING

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Mondovì, 12084, Italy

WITHDRAWN

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Monza, 20900, Italy

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Naples, 80131, Italy

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Novara, 28100, Italy

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Orbassano, 10043, Italy

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Palermo, 90127, Italy

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Pavia, 27100, Italy

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Potenza, 85100, Italy

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Roma, 00128, Italy

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Roma, 00133, Italy

RECRUITING

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Roma, 161, Italy

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Rome, 00168, Italy

RECRUITING

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Rozzano, 20089, Italy

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Siena, 53100, Italy

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Torino, 10126, Italy

RECRUITING

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Udine, 33100, Italy

RECRUITING

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Amagasaki-shi, 660-8550, Japan

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Asahikawa-shi, 070-8610, Japan

RECRUITING

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Azumino-shi, 399-8292, Japan

RECRUITING

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Chūōku, 103-0002, Japan

RECRUITING

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Fukui-shi, 910-8526, Japan

RECRUITING

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Hakusan-shi, 924-8588, Japan

RECRUITING

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Himeji, 670-8560, Japan

RECRUITING

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Itabashi-ku, 173-0015, Japan

RECRUITING

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Izumo-shi, 693-8501, Japan

RECRUITING

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Kakegawa-shi, 436-8555, Japan

RECRUITING

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Kamakura-shi, 247-8533, Japan

RECRUITING

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Kanazawa, 920-8650, Japan

RECRUITING

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Kawaguchi-shi, 332-8558, Japan

RECRUITING

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Kishiwada-shi, 596-0042, Japan

RECRUITING

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Kita-ku, 114-0001, Japan

RECRUITING

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Kyoto, 601-1495, Japan

COMPLETED

Research Site

Kyoto, 605-0981, Japan

RECRUITING

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Kyoto, 606-8507, Japan

RECRUITING

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Matsudo-shi, 271-0077, Japan

RECRUITING

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Meguro-ku, 153-0051, Japan

RECRUITING

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Mito, 311-4198, Japan

RECRUITING

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Miyazaki, 880-0834, Japan

RECRUITING

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Nagano, 399-8695, Japan

RECRUITING

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Ogaki-shi, 503-8502, Japan

RECRUITING

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Osaka, 530-8480, Japan

RECRUITING

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Osaka, 534-0024, Japan

COMPLETED

Research Site

Osaka, 553-0003, Japan

RECRUITING

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Osaka, 558-8558, Japan

RECRUITING

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Ōita, 870-8511, Japan

RECRUITING

Research Site

Ōmihachiman, 523-0082, Japan

RECRUITING

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Saitama-shi, 338-0837, Japan

RECRUITING

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Sendai, 980-8574, Japan

RECRUITING

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Sendai, 983-0039, Japan

RECRUITING

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Shizuoka, 424-0911, Japan

RECRUITING

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Suita-shi, 564-8565, Japan

RECRUITING

Research Site

tabashi City, 173-8606, Japan

WITHDRAWN

Research Site

Takamatsu, 760-0017, Japan

RECRUITING

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Takatsuki-shi, 569-1192, Japan

RECRUITING

Research Site

Toyota-Shi, 471-8513, Japan

RECRUITING

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Tsuchiura-shi, 300-0028, Japan

RECRUITING

Research Site

Ueda-shi, 386-8610, Japan

RECRUITING

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Uwajima-shi, 798-8510, Japan

RECRUITING

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Yanagawa-shi, 832-0077, Japan

RECRUITING

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Yokkaichi-shi, 510-8561, Japan

RECRUITING

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Yokohama, 230-8765, Japan

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Alor Star, 05460, Malaysia

RECRUITING

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Johor Bahru, 80100, Malaysia

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Kota Samarahan, 94300, Malaysia

RECRUITING

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Kuala Terengganu, 20400, Malaysia

RECRUITING

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Kuantan, 25100, Malaysia

RECRUITING

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Kuching, 93586, Malaysia

RECRUITING

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Malacca, 78300, Malaysia

WITHDRAWN

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Rawang, 48050, Malaysia

RECRUITING

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Sarawak Miri, 98000, Malaysia

RECRUITING

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Seri Manjung, 32040, Malaysia

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Sungai Buloh, 47000, Malaysia

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Acapulco, 39670, Mexico

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Aguascalientes, 20230, Mexico

RECRUITING

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Cuauhtémoc, 6720, Mexico

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Cuernavaca, 62448, Mexico

RECRUITING

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Culiacán, 80200, Mexico

NOT YET RECRUITING

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Culiacán, 80230, Mexico

RECRUITING

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Durango, 34000, Mexico

RECRUITING

Research Site

Guadalajara, 44670, Mexico

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Guadalajara, 44670, Mexico

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Mexico City, 10700, Mexico

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Monterrey, 64060, Mexico

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Querétaro City, 76000, Mexico

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San Juan del Río, 76800, Mexico

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Veracruz, 91910, Mexico

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Xalapa, 91020, Mexico

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Xalapa, 91193, Mexico

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Zapopan, 45138, Mexico

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's-Hertogenbosch, 5223 LA, Netherlands

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Almelo, 7609 PP, Netherlands

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Amsterdam, 1081 GM, Netherlands

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Amsterdam, 1105 AZ, Netherlands

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Born, 6121 XK, Netherlands

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Deventer, 7416 SE, Netherlands

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Ede, 6716 RP, Netherlands

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Enschede, 7512 KZ, Netherlands

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Haarlem, 2035 RC, Netherlands

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Harderwijk, 3844, Netherlands

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Hoogeveen, 7909 AA, Netherlands

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Nijmegen, 6525 GA, Netherlands

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Roosendaal, 4708 AE, Netherlands

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Rotterdam, 3015GD, Netherlands

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Rotterdam, 3045 PM, Netherlands

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Venlo, 5912 BL, Netherlands

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Zwolle, 8025AZ, Netherlands

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Bellavista, CALLAO 2, Peru

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Callao, Bellavista, Peru

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Chorrillos, Lima 9, Peru

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Cusco, CUSCO 01, Peru

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Lima, 14, Peru

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Lima, 15036, Peru

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Lima, 15046, Peru

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Lima, 15072, Peru

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Lima, 15074, Peru

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Lima, 15088, Peru

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Lima, 15102, Peru

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Lima, 15131, Peru

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Lima, L18, Peru

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Lima, LIMA 01, Peru

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Lima, LIMA 11, Peru

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Lima, LIMA 41, Peru

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Piura, 20001, Peru

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Angeles City, 2009, Philippines

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Cebu, 6000, Philippines

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Davao City, 8000, Philippines

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Davao City, PH-8000, Philippines

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Fuente Osmena Cebu City, 6000, Philippines

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Iloilo City, 5000, Philippines

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Las Piñas, 1742, Philippines

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Lipa City, 4217, Philippines

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Manadaluyong City, 1552, Philippines

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Puerto Princesa City, 5300, Philippines

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Quezon City, 1100, Philippines

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Roxas City, 5800, Philippines

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Bialystok, 15-481, Poland

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Biała Podlaska, 21-500, Poland

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Bydgoszcz, 85-095, Poland

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Chojnice, 89-600, Poland

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Chojnice, 89-600, Poland

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Chrzanów, 32-500, Poland

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Częstochowa, 42-202, Poland

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Gdansk, 80-214, Poland

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Gdansk, 80-286, Poland

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Gdynia, 81-157, Poland

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Gdynia, 81-537, Poland

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Jasło, 38-200, Poland

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Katowice, 40-040, Poland

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Katowice, 40-081, Poland

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Katowice, 40-156, Poland

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Katowice, 40-600, Poland

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Katowice, 40-748, Poland

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Katowice, 40-752, Poland

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Krakow, 31-121, Poland

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Krakow, 31-322, Poland

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Lodz, 90-302, Poland

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Lodz, 90-549, Poland

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Lublin, 20-068, Poland

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Lublin, 20-518, Poland

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Lublin, 20-718, Poland

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Lublin, 20-857, Poland

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Myszków, 42-300, Poland

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Olsztyn, 10-165, Poland

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Ostrów Mazowiecka, 07-300, Poland

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Piekary Śląskie, 41-940, Poland

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Poznan, 60-111, Poland

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Poznan, 60-309, Poland

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Poznan, 60-702, Poland

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Poznan, 61-848, Poland

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Przemyśl, 37-700, Poland

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Płock, 09-407, Poland

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Radzionków, 41-922, Poland

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Rzeszów, 35-205, Poland

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Skórzewo, 60-185, Poland

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Szczecin, 71-434, Poland

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Szczecin, 71-526, Poland

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Tarnów, 33-100, Poland

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Torun, 87-100, Poland

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Warsaw, 00-124, Poland

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Warsaw, 00-872, Poland

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Warsaw, 02-507, Poland

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Warsaw, 02-758, Poland

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Warsaw, 02-798, Poland

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Warsaw, 04-501, Poland

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Warsaw, 04-628, Poland

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Wroclaw, 50-981, Poland

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Zabrze, 41-800, Poland

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Bacau, 600274, Romania

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Baia Mare, 430124, Romania

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Baia Mare, 430222, Romania

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Brasov, 500102, Romania

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Bucharest, 010507, Romania

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Bucharest, 010825, Romania

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Bucharest, 012296, Romania

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Bucharest, 020475, Romania

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Bucharest, 031818, Romania

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Bucharest, 050098, Romania

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Craiova, 200642, Romania

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Iași, 700515, Romania

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Ploieşti, 100179, Romania

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Satu Mare, 440055, Romania

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Târgu Mureş, 540136, Romania

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Bratislava, 831 03, Slovakia

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Bratislava, 83101, Slovakia

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Bratislava, 83106, Slovakia

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Brezno, 977 01, Slovakia

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Handlová, 972 51, Slovakia

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Košice, 04001, Slovakia

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Košice, 04022, Slovakia

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Lučenec, 984 01, Slovakia

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Ľubochňa, 03491, Slovakia

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Malacky, 901 22, Slovakia

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Námestovo, 029 01, Slovakia

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Prešov, 080 01, Slovakia

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Prievidza, 97101, Slovakia

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Rimavská Sobota, 979 01, Slovakia

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Rožňava, 048 01, Slovakia

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Sabinov, 08301, Slovakia

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Svidník, 08901, Slovakia

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Bellville, 7530, South Africa

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Benoni, 1501, South Africa

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Brackenfell, 7560, South Africa

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Cape Town, 1730, South Africa

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Cape Town, 7500, South Africa

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Centurion, 0157, South Africa

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Claremont, 7708, South Africa

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Diepkloof, Soweto, 2013, South Africa

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Durban, 4001, South Africa

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Durban, 4052, South Africa

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East London, 5219, South Africa

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eMkhomazi, 4170, South Africa

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Johannesburg, 1827, South Africa

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Lenasia, 1827, South Africa

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Midrand, 1685, South Africa

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Paarl, 7646, South Africa

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Pretoria, 0184, South Africa

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Pretoria, 0186, South Africa

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Somerset West, 7130, South Africa

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Wentworth, 4032, South Africa

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Worcester, 6850, South Africa

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Bucheon-si, 14754, South Korea

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Cheongju-si, 28644, South Korea

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Daegu, 42601, South Korea

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Seongnam-si, 13620, South Korea

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Seoul, 02841, South Korea

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Seoul, 03080, South Korea

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Seoul, 06591, South Korea

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Seoul, 08308, South Korea

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Seoul, 120-752, South Korea

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Seoul, 135-710, South Korea

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Seoul, 5505, South Korea

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Suwon, 16499, South Korea

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Wŏnju, 26426, South Korea

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Yangsan, 50612, South Korea

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A Coruña, 15006, Spain

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Barcelona, 08003, Spain

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Barcelona, 08036, Spain

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Barcelona, 08041, Spain

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Córdoba, 14004, Spain

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Córdoba, 14940, Spain

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L'Hospitalet de Llobregat, 08907, Spain

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Madrid, 28040, Spain

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Málaga, 29010, Spain

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Sant Joan Despí, 08970, Spain

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Santiago(A Coruña), 15706, Spain

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Seville, 41004, Spain

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Seville, 41071, Spain

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Valencia, 46010, Spain

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Vigo, 36312, Spain

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Gothenburg, 413 46, Sweden

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Helsingborg, 252 21, Sweden

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Huddinge, 141 86, Sweden

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Lund, 222 21, Sweden

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Lund, 222 42, Sweden

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Mölndal, 431 80, Sweden

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Norrköping, 603 79, Sweden

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Stockholm, 113 61, Sweden

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Stockholm, 117 27, Sweden

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Stockholm, 118 83, Sweden

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Uppsala, 751 85, Sweden

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Uppsala, 75233, Sweden

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Changhua, 500, Taiwan

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Hsinchu, 300, Taiwan

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Hualien City, 970473, Taiwan

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Kaohsiung City, 80756, Taiwan

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New Taipei City, 231, Taiwan

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Taichung, 40201, Taiwan

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Taichung, 404, Taiwan

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Taichung, 40705, Taiwan

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Taichung, 433004, Taiwan

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Tainan, 710, Taiwan

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Taipei, 10002, Taiwan

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Taipei, 10449, Taiwan

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Taipei, 110, Taiwan

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Taipei, 11101, Taiwan

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Taipei, 11217, Taiwan

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Taipei, 11490, Taiwan

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Taipei, 116, Taiwan

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Taoyuan, 333, Taiwan

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Bangkok, 10330, Thailand

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Bangkok, 10700, Thailand

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Banphaeo, 74120, Thailand

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Bansuan, Muang, Chonburi, 20000, Thailand

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Chiang Mai, 50200, Thailand

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Dusit, 10300, Thailand

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Hat Yai, 90110, Thailand

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Khlong Luang, 12120, Thailand

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Khon Kaen, 40002, Thailand

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Muang, 22000, Thailand

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Naimuang, 30000, Thailand

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Ubonratchathani, 34000, Thailand

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Adana, 01130, Turkey (Türkiye)

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Afyonkarahisar, 03030, Turkey (Türkiye)

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Ankara, 06530, Turkey (Türkiye)

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Antalya, 07059, Turkey (Türkiye)

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Eskişehir, 26040, Turkey (Türkiye)

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Istanbul, 34303, Turkey (Türkiye)

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Istanbul, 34899, Turkey (Türkiye)

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Izmir, 35340, Turkey (Türkiye)

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Kahramanmaraş, 46100, Turkey (Türkiye)

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Kocaeli, 41001, Turkey (Türkiye)

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Kütahya, 43100, Turkey (Türkiye)

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Malatya, 44280, Turkey (Türkiye)

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Samsun, 55270, Turkey (Türkiye)

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Sivas, 58140, Turkey (Türkiye)

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Chernivtsі, 58002, Ukraine

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Ivano-Frankivsk, 76018, Ukraine

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Kyiv, 01601, Ukraine

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Kyiv, 02081, Ukraine

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Kyiv, 03037, Ukraine

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Kyiv, 03151, Ukraine

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Kyiv, 03680, Ukraine

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Kyiv, 04050, Ukraine

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Ternopil, 46000, Ukraine

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Ternopil, 46002, Ukraine

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Uzhhorod, 88014, Ukraine

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Vinnytsia, 21001, Ukraine

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Vinnytsia, 21029, Ukraine

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Zhytomyr, 100002, Ukraine

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Aberdeen, AB25 2ZN, United Kingdom

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Chesterfield, S40 4AA, United Kingdom

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Dundee, DD1 9SY, United Kingdom

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Gatley, SK8 4NQ, United Kingdom

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Glasgow, G31 2ER, United Kingdom

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Glasgow, G51 4TF, United Kingdom

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London, E11BB, United Kingdom

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Norwich, NR128DU, United Kingdom

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Penzance, TR18 3DX, United Kingdom

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Redruth, TR16 4ET, United Kingdom

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Sandbach, CW11 1EQ, United Kingdom

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Southampton, SO303JB, United Kingdom

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Stockton-on-Tees, TS19 8PE, United Kingdom

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Swansea, SA6 6NL, United Kingdom

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Weston-super-Mare, BS24 7PR, United Kingdom

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Wolverhampton, WV10 0QP, United Kingdom

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Woodbridge, IP136TH, United Kingdom

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Yate, BS37 4AX, United Kingdom

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Can Tho, 900000, Vietnam

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Haiphong, 180000, Vietnam

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Hanoi, 10000, Vietnam

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Hà Nội, 100000, Vietnam

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Ho Chi Minh City, 700000, Vietnam

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Ho Chi Minh City, 700000, Vietnam

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Ho Chi Minh City, 70000, Vietnam

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Huế, 530000, Vietnam

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Rach Gia, 920000, Vietnam

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Vĩnh Yên, 280000, Vietnam

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Related Publications (1)

  • Dwyer JP, Maklad N, Vedin O, Monyak J, Myte R, Chertow GM, Heerspink HJL, Little DJ. Efficacy and Safety of Baxdrostat in Participants with CKD and Uncontrolled Hypertension: A Randomized, Double-Blind, Placebo-Controlled Trial. J Am Soc Nephrol. 2026 Feb 1;37(2):299-311. doi: 10.1681/ASN.0000000849. Epub 2025 Sep 6.

MeSH Terms

Conditions

Heart Failure

Interventions

dapagliflozin

Condition Hierarchy (Ancestors)

Heart DiseasesCardiovascular Diseases

Central Study Contacts

AstraZeneca Clinical Study Information Center

CONTACT

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Masking Details
Placebo controlled
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

November 5, 2024

First Posted

November 6, 2024

Study Start

March 14, 2025

Primary Completion (Estimated)

December 17, 2029

Study Completion (Estimated)

December 17, 2029

Last Updated

May 18, 2026

Record last verified: 2026-05

Data Sharing

IPD Sharing
Will share

Qualified researchers can request access to anonymized individual patient-level data from AstraZeneca group of companies sponsored clinical trials via the request portal Vivli.org. All requests will be evaluated as per the AZ disclosure commitment: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure. "Yes", indicates that AZ are accepting requests for IPD, but this does not mean all requests will be approved.

Shared Documents
STUDY PROTOCOL, SAP
Time Frame
AstraZeneca will meet or exceed data availability as per the commitments made to the EFPIA/PhRMA Data-Sharing Principles. For details of our timelines, please refer to our disclosure commitment at: https://astrazenecagrouptrials.pharmacm.com/ST/Submission/Disclosure
Access Criteria
When a request has been approved AstraZeneca will provide access to the anonymized individual patient-level data via secure research environment Vivli.org. A Signed Data Usage Agreement (non-negotiable contract for data accessors) must be in place before accessing requested information
More information

Locations