Creatine Supplementation in Young Healthy Adults

NCT06604793 | Recruiting

• 1 other identifier: 834
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

The purpose is to compare the effects of bolus ingestion (5 grams) vs. intermittent ingestion (2 x 2.5 grams) of creatine supplementation vs. placebo for 21 days on measures of body composition (lean tissue mass-indicator of muscle mass, total body water) and muscle performance (i.e., power, strength, endurance).

Conditions

Improve Muscle Performance in Young Adults

Outcome Measures

Primary Outcomes (6)

• Whole-body lean mass (kg)

  Bioelectrical impedance analysis

  baseline, day 21

• Strength

  1-repetition maximum leg press and chest press (kg)

  baseline, day 21

• Endurance

  Repetitions to fatigue for leg press and chest press (total number)

  baseline, day 21

• Hydration

  Total body water (kg) using bioelectrical impedance analysis

  baseline, day 21

• Power

  Vertical Jump (cm)

  baseline, day 21

• Power

  Medicine Ball Throw (feet)

  baseline, day 21

Study Arms (3)

Creatine Bolus

EXPERIMENTAL

(Serving 1: 5 grams of creatine monohydrate + 3 grams of placebo in the morning; Serving 2: 8 grams of placebo in the evening) for 21 days.

Dietary Supplement: Creatine

Creatine Intermittent

EXPERIMENTAL

(Serving 1: 2.5 grams of creatine monohydrate + 5.5 grams of placebo in the morning; Serving 2: 2.5 grams of creatine monohydrate + 5.5 grams of placebo in the evening) for 21 days.

Dietary Supplement: Creatine

Placebo

PLACEBO COMPARATOR

(Servings 1: 8 grams of placebo in the morning; Serving 2: 8 grams of placebo in the evening) for 21 days.

Dietary Supplement: Placebo

Interventions

Creatine DIETARY_SUPPLEMENT

Creatine monohydrate

Creatine Bolus; Creatine Intermittent

Placebo DIETARY_SUPPLEMENT

Maltodextrin

Placebo

Eligibility Criteria

• Age: 18 Years - 39 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• if you are 18-39 years of age
• if you have not been performing resistance training for at least 4 weeks prior to the start of the study.

You may not qualify if:

• if you are pregnant or nursing
• have taken creatine monohydrate within 30 days prior to the start of the study
• if you have pre-existing allergies to the placebo (corn-starch maltodextrin)

Sponsors & Collaborators

• University of Regina: lead
• Iovate Health Sciences International Inc: collaborator

Study Sites (1)

University of Regina

Regina, Saskatchewan, S4S 0A2, Canada

RECRUITING

MeSH Terms

Interventions

Creatine

Intervention Hierarchy (Ancestors)

Guanidines; Amidines; Organic Chemicals; Amino Acids; Amino Acids, Peptides, and Proteins

Study Officials

• Darren Candow

  University of Regina

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Darren Candow

CONTACT

306-585-4906; Darren.Candow@uregina.ca

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 17, 2024
• First Posted: September 20, 2024
• Study Start: August 20, 2024
• Primary Completion: January 31, 2025
• Study Completion: January 31, 2025
• Last Updated: September 20, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)