Strategic Ingestion of Creatine Supplementation and Resistance Training in Trained Young Adults

NCT06438887 | Recruiting

• 1 other identifier: Bio-REB 4641
• Study Type: interventional
• Target: 52
• Locations: 1 country
• Sites: 2

Brief Summary

Creatine supplementation improves measures of muscle accretion and performance compared to placebo during a resistance training program. However, the optimal creatine supplementation protocol for maximizing these improvements is unknown.

Conditions

Strength; Muscle

Outcome Measures

Primary Outcomes (7)

• Body Composition

  Whole-body lean mass (kg) using bioelectrical impedance analysis

  baseline, week 16

• Muscle Hypertrophy

  Muscle thickness of the biceps, triceps, quadriceps, hamstrings and calf muscle using B-mode ultrasound (cm)

  baseline, week 16

• Strength

  1-repetition maximum leg press and chest press (kg)

  baseline, week 16

• Endurance

  Repetitions to fatigue for leg press and chest press (total number)

  baseline, week 16

• Power

  Medicine ball throw (cm)

  baseline, week 16

• Hydration

  Total body water (kg) using bioelectrical impedance analysis

  baseline, week 16

• Power

  Vertical jump (watts)

  baseline, weekn 16

Study Arms (4)

Creatine Before Training

EXPERIMENTAL

5 grams of creatine monohydrate + 3 grams of placebo immediately before training sessions; 8 grams of placebo immediately after training sessions; 8 grams of placebo on non-training days.

Dietary Supplement: Placebo; Dietary Supplement: Creatine monohydrate

Creatine After Training

EXPERIMENTAL

5 grams of creatine monohydrate + 3 grams of placebo immediately after training sessions; 8 grams of placebo immediately before training sessions; 8 grams of placebo on non-training days.

Dietary Supplement: Placebo; Dietary Supplement: Creatine monohydrate

Creatine Non-Training

EXPERIMENTAL

5 grams of creatine monohydrate + 3 grams of placebo on non-training days; 8 grams of placebo immediately before training sessions; 8 grams of placebo immediately after training sessions.

Dietary Supplement: Placebo; Dietary Supplement: Creatine monohydrate

Placebo

PLACEBO COMPARATOR

8 grams of placebo immediately before training sessions; 8 grams of placebo immediately after training sessions; 8 grams of placebo on non-training days

Dietary Supplement: Placebo

Interventions

Placebo DIETARY_SUPPLEMENT

Corn-Starch Maltodextrin

Creatine After Training; Creatine Before Training; Creatine Non-Training; Placebo

Creatine monohydrate DIETARY_SUPPLEMENT

Creatine

Creatine After Training; Creatine Before Training; Creatine Non-Training

Eligibility Criteria

• Age: 18 Years - 39 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Physically active (performing structured resistance training \> 2x/week for ≥ 4 weeks)
• Males and females (age 18-39)

You may not qualify if:

• Pregnant or nursing
• Have consumed creatine monohydrate within 30 days prior to the start of the study
• Pre-existing allergies to the placebo

Sponsors & Collaborators

• University of Regina: lead

Study Sites (2)

University of Regina

Regina, Saskatchewan, S4S4H4, Canada

RECRUITING

University of Regina

Regina, Canada

RECRUITING

MeSH Terms

Interventions

Creatine

Intervention Hierarchy (Ancestors)

Guanidines; Amidines; Organic Chemicals; Amino Acids; Amino Acids, Peptides, and Proteins

Study Officials

• Darren Candow

  University of Regina

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Darren Candow

CONTACT

3062090280; Darren.Candow@uregina.ca

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: blinding
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Double-blind, randomized controlled trial

Study Record Dates

• First Submitted: May 16, 2024
• First Posted: June 3, 2024
• Study Start: May 15, 2024
• Primary Completion: December 30, 2024
• Study Completion: August 30, 2025
• Last Updated: June 3, 2024

Record last verified: 2024-05

Data Sharing

• IPD Sharing: Will not share

Locations

CA (2)