Creatine Supplementation in Chronic Fatigue Syndrome
CREFAS
The Effects of Medium-term Creatine Supplementation in Adults With Chronic Fatigue Syndrome
1 other identifier
interventional
60
0 countries
N/A
Brief Summary
This study evaluates the effectiveness of medium-term supplementation with creatine to improve clinical outcomes in well-defined adult CFS population. Half of the participants will receive creatine while the other half will receive placebo.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for not_applicable
Started Jan 2016
Longer than P75 for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 22, 2015
CompletedFirst Posted
Study publicly available on registry
February 27, 2015
CompletedStudy Start
First participant enrolled
January 1, 2016
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 1, 2025
CompletedStudy Completion
Last participant's last visit for all outcomes
December 1, 2025
CompletedMay 23, 2025
May 1, 2025
9.9 years
February 22, 2015
May 22, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Multidimensional Fatigue Inventory (MFI) score
3 months
Secondary Outcomes (1)
health-related quality of life
3 months
Study Arms (2)
Experimental
EXPERIMENTALCreatine supplementation
Control
PLACEBO COMPARATORPlacebo supplementation
Interventions
Eligibility Criteria
You may qualify if:
- older than 18 years
- fulfilled CDC criteria for CFS
You may not qualify if:
- psychiatric co-morbidity
- use of dietary supplement within 4-weeks prior to the study commencing
- pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Related Publications (2)
Vermeulen RC, Kurk RM, Visser FC, Sluiter W, Scholte HR. Patients with chronic fatigue syndrome performed worse than controls in a controlled repeated exercise study despite a normal oxidative phosphorylation capacity. J Transl Med. 2010 Oct 11;8:93. doi: 10.1186/1479-5876-8-93.
PMID: 20937116BACKGROUNDHollingsworth KG, Jones DE, Taylor R, Blamire AM, Newton JL. Impaired cardiovascular response to standing in chronic fatigue syndrome. Eur J Clin Invest. 2010 Jul;40(7):608-15. doi: 10.1111/j.1365-2362.2010.02310.x. Epub 2010 May 23.
PMID: 20497461BACKGROUND
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Sergej M Ostojic, MD, PhD
Center for Health, Exercise and Sport Sciences
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, CARE PROVIDER
- Purpose
- TREATMENT
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor
Study Record Dates
First Submitted
February 22, 2015
First Posted
February 27, 2015
Study Start
January 1, 2016
Primary Completion
December 1, 2025
Study Completion
December 1, 2025
Last Updated
May 23, 2025
Record last verified: 2025-05