Effects of Resistance-band Training and Creatine Supplementation Strategies in Healthy Older Adults

NCT06606704 | Recruiting

• 1 other identifier: 853
• Study Type: interventional
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

The primary purpose is to compare the effects of creatine supplementation (bolus ingestion of 5 grams vs. 3 grams) during 16 weeks of resistance-band training on measures of body composition (i.e., whole-body lean tissue mass, total body water), arm and leg muscle thickness (growth), muscle performance (i.e., power, strength, endurance) and functional ability (i.e., walking speed, balance). A secondary purpose of this research is to examine the effects of bolus ingestion of creatine (5 grams) compared to intermittent ingestion of creatine (2 x 2.5 grams) during 16 weeks of resistance-band training on measures of body composition (i.e., whole-body lean tissue mass, total body water), arm and leg muscle thickness (growth), muscle performance (i.e., power, strength, endurance) and functional ability (i.e., walking speed, balance).

Conditions

Aging

Keywords

Aging; Creatine; Resistance-Bands; Muscle; Strength

Outcome Measures

Primary Outcomes (7)

• Whole-body lean mass (kg)

  Bioelectrical impedance analysis

  baseline, week 16

• Muscle Hypertrophy (cm)

  B-mode ultrasound

  baseline, week 16

• Strength (kg)

  1-repetition maximum leg press and chest press

  baseline, week 16

• Endurance (number of repetitions to fatigue)

  Leg press and chest press

  baseline, week 16

• Power (feet)

  medicine ball throw

  baseline, week 16

• Balance (Centre of Pressure)

  Force Plate

  baseline, week 16

• Gait Speed (meters)

  Walking distance

  baseline, week 16

Study Arms (4)

Creatine Bolus 5

EXPERIMENTAL

Dietary Supplement: Creatine Bolus 5

Creatine Bolus 3

EXPERIMENTAL

Dietary Supplement: Creatine Bolus 3

Creatine Intermittent 5

EXPERIMENTAL

Dietary Supplement: Creatine Intermittent 5

Placebo

PLACEBO COMPARATOR

Dietary Supplement: Placebo

Interventions

Creatine Bolus 5 DIETARY_SUPPLEMENT

(Serving 1: 5 grams of creatine + 3 grams of placebo in the morning; Serving 2: 8 grams of placebo at least 6 hours after Serving 1).

Creatine Bolus 5

Creatine Bolus 3 DIETARY_SUPPLEMENT

(Serving 1: 3 grams of creatine + 5 grams of placebo in the morning; Serving 2: 8 grams of placebo at least 6 hours after Serving 1).

Creatine Bolus 3

Creatine Intermittent 5 DIETARY_SUPPLEMENT

(Serving 1: 2.5 grams of creatine + 5.5 grams of placebo in the morning, Serving 2: 2.5 grams of creatine + 5.5 grams of placebo at least 6 hours after Serving 1).

Creatine Intermittent 5

Placebo DIETARY_SUPPLEMENT

(Serving: 8 grams of placebo in the morning; Servings 2: 8 grams of placebo at least 6 hours after Serving 1).

Placebo

Eligibility Criteria

• Age: 50 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• if you are 50 years of age and older
• if you have not been performing more than 1 resistance training session per week for the past 6 weeks or more.

You may not qualify if:

• if you have taken creatine supplements within 30 days prior to the start of the study
• if you have pre-existing allergies to the placebo (corn-starch maltodextrin).

Sponsors & Collaborators

• University of Regina: lead
• Iovate Health Sciences International Inc: collaborator

Study Sites (1)

University of Regina

Regina, Saskatchewan, S4S4H4, Canada

RECRUITING

Study Officials

• Darren Candow

  University of Regina

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Darren Candow

CONTACT

306-585-4906; Darren.Candow@uregina.ca

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: September 16, 2024
• First Posted: September 23, 2024
• Study Start: August 20, 2024
• Primary Completion: July 30, 2025
• Study Completion: July 30, 2025
• Last Updated: September 23, 2024

Record last verified: 2024-09

Data Sharing

• IPD Sharing: Will not share

Locations

CA (1)