Effects of Short Term Creatine Supplementation in Hemodialysis Patients

NCT07033611 | Completed

• 1 other identifier: ORD252023
• Study Type: interventional
• Target: 18
• Locations: 1 country
• Sites: 1

Brief Summary

Adult patients undergoing chronic dialysis therapy for at least three months were selected. A physical function assessment was conducted, including the Short Physical Performance Battery (SPPB) and a handgrip strength test. Additionally, a bioelectrical impedance analysis was performed. Subsequently, 5 grams of creatine were administered daily for a period of eight weeks, after which the same assessments were repeated. The results were then analyzed to identify any differences in the tests, aiming to detect potential changes following creatine supplementation.

Conditions

Dialysis; Complications; Performance Enhancing Product Use

Keywords

dialysis; poor physical performance; creatine; body composition; Short Physical Performance Battery (SPPB); handgrip test

Outcome Measures

Primary Outcomes (1)

• Compare Short Physical Performance Battery (SPPB) before and after 8 weeks of creatine use

  To compare the physical functionality status of selected patients, as assessed by the Short Physical Performance Battery (SPPB), before and after eight weeks of creatine supplementation. Scale range between 0-12 points. Higher points mean a better outcome (higher physical functionality).

  eigth weeks

Secondary Outcomes (7)

• Compare hand grip strength as assessed by a hand dynamometer, before and after eight weeks of creatine supplementation

  eigth weeks

• Compare body composition: skeletal muscle mass, estimated by bioimpedance analysis before and after eight weeks of creatine supplementation

  eigth weeks

• Compare body composition: fat free mass, estimated by bioimpedance analysis before and after eight weeks of creatine supplementation

  eigth weeks

• Compare body composition: total body water (Lt), estimated by bioimpedance analysis before and after eight weeks of creatine supplementation

  eigth weeks

• Compare body composition: extracellular water (Lt), estimated by bioimpedance analysis before and after eight weeks of creatine supplementation

  eigth weeks

Study Arms (1)

Pre creatine and post

EXPERIMENTAL

patients before and after creatine suplemmentation

Dietary Supplement: Creatine

Interventions

Creatine DIETARY_SUPPLEMENT

Five grams of creatine were administered to each patient daily for eight weeks.

Pre creatine and post

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Eligible to provide informed consent
• At least three months on chronic dialysis therapy
• No physical impairments that would prevent completion of the SPPB or bioelectrical impedance analysis

You may not qualify if:

• Pregnancy
• Use of any nutritional supplement

Sponsors & Collaborators

• Carla Basualto Alarcón: lead

Study Sites (1)

Hospital de Puerto Aysen

Puerto Aisén, Región de Aysen, Chile

Location

Related Publications (27)

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MeSH Terms

Interventions

Creatine

Intervention Hierarchy (Ancestors)

Guanidines; Amidines; Organic Chemicals; Amino Acids; Amino Acids, Peptides, and Proteins

Study Officials

• Carla Basualto-Alarcón, PhD

  Universidad de Aysén

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate Professor, U Aysen. MD., MSc., PhD.

Model Details: Functional assessments and bioelectrical impedance analysis conducted pre- and post-creatine supplementation

Study Record Dates

• First Submitted: June 2, 2025
• First Posted: June 24, 2025
• Study Start: January 1, 2024
• Primary Completion: February 28, 2024
• Study Completion: February 28, 2024
• Last Updated: June 24, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will share

Locations

CL (1)