NCT06208150

Brief Summary

The purpose of this study is to compare the effectiveness of either talquetamab plus pomalidomide (Tal-P) or talquetamab plus teclistamab (Tal-Tec) with elotuzumab, pomalidomide, and dexamethasone (EPd) or pomalidomide, bortezomib, and dexamethasone (PVd).

Trial Health

88
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Strong global presence with extensive site network
Enrollment
795

participants targeted

Target at P75+ for phase_3 multiple-myeloma

Timeline
23mo left

Started Jan 2024

Geographic Reach
26 countries

235 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress55%
Jan 2024Mar 2028

First Submitted

Initial submission to the registry

January 5, 2024

Completed
12 days until next milestone

First Posted

Study publicly available on registry

January 17, 2024

Completed
5 days until next milestone

Study Start

First participant enrolled

January 22, 2024

Completed
2.3 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 23, 2026

Completed
1.9 years until next milestone

Study Completion

Last participant's last visit for all outcomes

March 31, 2028

Expected
Last Updated

March 13, 2026

Status Verified

March 1, 2026

Enrollment Period

2.3 years

First QC Date

January 5, 2024

Last Update Submit

March 12, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Progression Free Survival (PFS)

    PFS is defined as the duration from the date of randomization to either progressive disease or death, whichever comes first.

    Up to 3 years 5 months

Secondary Outcomes (21)

  • Overall Response Rate (ORR)

    Up to 3 years 5 months

  • Complete Response (CR) or Better Rate

    Up to 3 years 5 months

  • Very Good Partial Response (VGPR) or Better Rate

    Up to 3 years 5 months

  • Minimal Residual Disease (MRD)-negative CR Rate

    Up to 3 years 5 months

  • Overall Survival (OS)

    Up to 3 years 5 months

  • +16 more secondary outcomes

Study Arms (3)

Arm A: Talquetamab + Pomalidomide (Tal-P)

EXPERIMENTAL

Participants will receive talquetamab as subcutaneous (SC) injections; pomalidomide will be self-administered as a single dose orally; dexamethasone may be given orally or intravenously as a pretreatment medication and study drug.

Drug: TalquetamabDrug: PomalidomideDrug: Dexamethasone

Arm B: Talquetamab + Teclistamab (Tal-Tec)

EXPERIMENTAL

Participants will receive teclistamab in combination with talquetamab both as SC injection; dexamethasone may be given orally or intravenously as a pretreatment medication and study drug.

Drug: TalquetamabDrug: TeclistamabDrug: Dexamethasone

Arm C: Elotuzumab+ Pomalidomide+Dexamethasone (EPd) or Pomalidomide+Bortezomib+Dexamethasone (PVd)

ACTIVE COMPARATOR

Participants will either receive elotuzumab intravenous (IV) injection in combination with pomalidomide and dexamethasone orally; or pomalidamide orally in combination with bortezomib SC injection and dexamethasone orally as per investigator choice. Dexamethasone will be administered as a pretreatment medication.

Drug: PomalidomideDrug: ElotuzumabDrug: DexamethasoneDrug: Bortezomib

Interventions

Talquetamab will be administered as a SC injection.

Also known as: JNJ-64407564, Talvey
Arm A: Talquetamab + Pomalidomide (Tal-P)Arm B: Talquetamab + Teclistamab (Tal-Tec)

Pomalidomide will be administered orally.

Also known as: Pomalyst, Imnovid
Arm A: Talquetamab + Pomalidomide (Tal-P)Arm C: Elotuzumab+ Pomalidomide+Dexamethasone (EPd) or Pomalidomide+Bortezomib+Dexamethasone (PVd)

Teclistamab will be administered as a SC injection.

Also known as: JNJ-64007957, Tecvayli
Arm B: Talquetamab + Teclistamab (Tal-Tec)

Elotuzumab will be administered intravenously.

Also known as: Empliciti
Arm C: Elotuzumab+ Pomalidomide+Dexamethasone (EPd) or Pomalidomide+Bortezomib+Dexamethasone (PVd)

Dexamethasone will be administered either orally or intravenously.

Arm A: Talquetamab + Pomalidomide (Tal-P)Arm B: Talquetamab + Teclistamab (Tal-Tec)Arm C: Elotuzumab+ Pomalidomide+Dexamethasone (EPd) or Pomalidomide+Bortezomib+Dexamethasone (PVd)

Bortezomib will be administered as a SC injection.

Also known as: Velcade
Arm C: Elotuzumab+ Pomalidomide+Dexamethasone (EPd) or Pomalidomide+Bortezomib+Dexamethasone (PVd)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Documented multiple myeloma as defined by the criteria below: (a) multiple myeloma diagnosis according to the international myeloma working group (IMWG) diagnostic criteria (b) measurable disease at screening as assessed by central laboratory, defined by any of the following: (i) serum M-protein level greater than or equal to (\>=) 0.5 gram per deciliter (g/dL); or (ii) urine M-protein level \>= 200 milligram (mg) per 24 hours; or (iii) light chain multiple myeloma without measurable M-protein in the serum or the urine: serum immunoglobulin (Ig) free light chain (FLC) \>= 10 milligrams per deciliter (mg/dL) and abnormal serum Ig kappa lambda FLC ratio
  • Relapsed or refractory disease as defined below: a) Relapsed disease is defined as an initial response to prior treatment, followed by confirmed progressive disease (PD) by IMWG criteria greater than (\>) 60 days after cessation of treatment. b) Refractory disease is defined as less than (\<) 25 percent (%) reduction in M-protein or confirmed PD by IMWG criteria during previous treatment or less than or equal to (\<=) 60 days after cessation of treatment
  • Documented evidence of PD or failure to achieve a minimal response to the last line of therapy based on investigator's determination of response by IMWG criteria on or after their last regimen
  • Have an Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1, or 2 at screening and immediately prior to the start of administration of study treatment
  • A participant must agree not to be pregnant, breastfeeding, or planning to become pregnant while enrolled in this study or within 6 months after the last dose of study treatment

You may not qualify if:

  • Contraindications or life-threatening allergies, hypersensitivity, or intolerance to any study drug or its excipients
  • Stroke, transient ischemic attack, or seizure within 6 months prior to signing informed consent form (ICF)
  • Major surgery or had significant traumatic injury within 2 weeks prior to the start of administration of study treatment, or will not have fully recovered from surgery, or has major surgery planned during the time the participant is expected to be treated in the study or within 2 weeks after administration of the last dose of study treatment
  • A maximum cumulative dose of corticosteroids of \>=140 mg of prednisone or equivalent within 14-day period before the first dose of study drug
  • Known active central nervous system (CNS) involvement or exhibits clinical signs of meningeal involvement of multiple myeloma. If either is suspected, negative whole brain magnetic resonance imaging (MRI) and lumbar cytology are required

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (242)

UCSF Fresno

Clovis, California, 93611, United States

RECRUITING

UCLA

Santa Monica, California, 90404, United States

RECRUITING

Yale University School Of Medicine

New Haven, Connecticut, 06519, United States

RECRUITING

Medical Oncology Hematology Consultants, PA

Newark, Delaware, 19713, United States

RECRUITING

Memorial Healthcare System

Hollywood, Florida, 33021, United States

RECRUITING

Moffitt Cancer Center

Tampa, Florida, 33612, United States

RECRUITING

Winship Cancer Institute Emory University

Atlanta, Georgia, 30322, United States

RECRUITING

City of Hope Cancer Center

Newnan, Georgia, 30265, United States

RECRUITING

Kootenai Health

Coeur d'Alene, Idaho, 83814, United States

COMPLETED

Loyola University Medical Center

Maywood, Illinois, 60153, United States

RECRUITING

University of Iowa Health Care

Waukee, Iowa, 50263, United States

RECRUITING

Norton Cancer Institute

Louisville, Kentucky, 40207, United States

RECRUITING

Our Lady of the Lake Hospital

Baton Rouge, Louisiana, 70808, United States

RECRUITING

Luminis Health Center for Cancer and Blood Disorders

Annapolis, Maryland, 21401, United States

COMPLETED

University of Maryland School of Medicine

Baltimore, Maryland, 21201, United States

RECRUITING

The Sidney Kimmel Comprehensive Cancer Center at John Hopkins

Baltimore, Maryland, 21287, United States

RECRUITING

University of Michigan

Ann Arbor, Michigan, 48109, United States

RECRUITING

Henry Ford Cancer Institute

Detroit, Michigan, 48202, United States

RECRUITING

Henry Ford Health Providence Southfield Hospital

Southfield, Michigan, 48075, United States

RECRUITING

University Of Minnesota

Minneapolis, Minnesota, 55455, United States

RECRUITING

Mayo Clinic Rochester

Rochester, Minnesota, 55905, United States

RECRUITING

Regions Hospital

Saint Paul, Minnesota, 55101, United States

COMPLETED

University of Nebraska

Omaha, Nebraska, 68105, United States

RECRUITING

Dartmouth Hitchcock Medical Center

Lebanon, New Hampshire, 03756, United States

RECRUITING

John Theurer Cancer Center at Hackensack University Medical Center

Hackensack, New Jersey, 07601, United States

RECRUITING

Roswell Park Cancer Institute

Buffalo, New York, 14263, United States

RECRUITING

Weill Cornell Medical College

New York, New York, 10065, United States

RECRUITING

SUNY Upstate Medical University

Syracuse, New York, 13210, United States

RECRUITING

Duke University Medical Center

Durham, North Carolina, 27705, United States

RECRUITING

Gabrail Cancer Center

Canton, Ohio, 44718, United States

RECRUITING

Louis Stokes Cleveland VA Med Ctr

Cleveland, Ohio, 44106, United States

COMPLETED

Cleveland Clinic

Cleveland, Ohio, 44195, United States

RECRUITING

Oregon Health And Science University

Portland, Oregon, 97239, United States

COMPLETED

Penn State Milton S Hershey Medical Ctr

Hershey, Pennsylvania, 17033, United States

RECRUITING

Thomas Jefferson University

Philadelphia, Pennsylvania, 19107 4215, United States

RECRUITING

West Penn Hospital

Pittsburgh, Pennsylvania, 15224, United States

RECRUITING

University Of Pittsburgh Medical Center UPMC Hillman Cancer Center

Pittsburgh, Pennsylvania, 15232, United States

COMPLETED

Medical University of South Carolina

Charleston, South Carolina, 29425-8900, United States

RECRUITING

Bon Secours Saint Francis Cancer Center

Greenville, South Carolina, 29607, United States

RECRUITING

UT Southwestern Parkland Hospital

Dallas, Texas, 75390, United States

RECRUITING

UT Southwestern

Dallas, Texas, 75390, United States

RECRUITING

Houston Methodist Neal Cancer Center at Texas Medical Center

Houston, Texas, 77030, United States

RECRUITING

Huntsman Cancer Institute

Salt Lake City, Utah, 84112, United States

RECRUITING

University of Virginia

Charlottesville, Virginia, 22903, United States

RECRUITING

Swedish Cancer Institute

Seattle, Washington, 98104, United States

RECRUITING

Fred Hutchinson Cancer Research Center

Seattle, Washington, 98109, United States

RECRUITING

NorthWest Medical Specialties, PLLC

Tacoma, Washington, 98405, United States

RECRUITING

Gundersen Health System

La Crosse, Wisconsin, 54601, United States

RECRUITING

Medical College Of Wisconsin

Milwaukee, Wisconsin, 53226, United States

RECRUITING

Fundaleu

Buenos Aires, C1114AAP, Argentina

ACTIVE NOT RECRUITING

Hospital Aleman

Buenos Aires, C1118AAT, Argentina

ACTIVE NOT RECRUITING

Hospital Britanico de Buenos Aires

Buenos Aires, C1280AEB, Argentina

COMPLETED

Royal Adelaide Hospital

Adelaide, 5000, Australia

ACTIVE NOT RECRUITING

Box Hill Hospital

Box Hill, 3128, Australia

ACTIVE NOT RECRUITING

St Vincents Hospital

Darlinghurst, 2010, Australia

ACTIVE NOT RECRUITING

St Vincents Hospital Melbourne

Fitzroy, 3065, Australia

ACTIVE NOT RECRUITING

Gold Coast University Hospital

Southport, 4215, Australia

ACTIVE NOT RECRUITING

Perth Blood Institute

West Perth, 6005, Australia

ACTIVE NOT RECRUITING

Wollongong Hospital

Wollongong, 2500, Australia

ACTIVE NOT RECRUITING

LKH - Universitätsklinikum der PMU Salzburg

Salzburg, 05020, Austria

ACTIVE NOT RECRUITING

Klinik Ottakring

Vienna, 1160, Austria

ACTIVE NOT RECRUITING

Medical University Vienna MUV

Vienna, A-1090, Austria

COMPLETED

Grand Hopital De Charleroi Site Les Viviers

Charleroi, 6060, Belgium

ACTIVE NOT RECRUITING

Ziekenhuis Oost-Limburg

Genk, 3600, Belgium

ACTIVE NOT RECRUITING

Ghent University Hospital

Ghent, 9000, Belgium

ACTIVE NOT RECRUITING

AZ Nikolaas - Campus Sint-Niklaas Moerland

Sint-Niklaas, 9100, Belgium

ACTIVE NOT RECRUITING

Cetus Oncologia

Belo Horizonte, 30110-022, Brazil

ACTIVE NOT RECRUITING

DF Star

Brasília, 70390-140, Brazil

ACTIVE NOT RECRUITING

Fundacao Universidade de Caxias do Sul

Caxias do Sul, 95070 560, Brazil

ACTIVE NOT RECRUITING

Hospital Erasto Gaertner- Liga Paranaense de Combate ao Cancer

Curitiba, 81520-060, Brazil

ACTIVE NOT RECRUITING

Hospital De Clinicas De Porto Alegre

Porto Alegre, 90035-903, Brazil

ACTIVE NOT RECRUITING

Instituto D Or de Pesquisa e Ensino IDOR

Recife, 50070-480, Brazil

ACTIVE NOT RECRUITING

Instituto de Educacao, Pesquisa e Gestao em Saude Instituto Americas (COI)

Rio de Janeiro, 22793-080, Brazil

ACTIVE NOT RECRUITING

Hospital Sao Rafael

Salvador, 41253 190, Brazil

ACTIVE NOT RECRUITING

Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base

São José do Rio Preto, 15090 000, Brazil

ACTIVE NOT RECRUITING

Real e Benemerita Associacao Portuguesa de Beneficencia

São Paulo, 01323 001, Brazil

ACTIVE NOT RECRUITING

Fundacao Antonio Prudente A C Camargo Cancer Center

São Paulo, 01509 900, Brazil

ACTIVE NOT RECRUITING

Clinica Medica Sao Germano S/S LTDA

São Paulo, 04537-081, Brazil

ACTIVE NOT RECRUITING

Instituto D Or de Pesquisa e Ensino

São Paulo, 04543 000, Brazil

ACTIVE NOT RECRUITING

Arthur J E Child Comprehensive Cancer Centre

Calgary, Alberta, T2N 5G2, Canada

ACTIVE NOT RECRUITING

British Columbia Cancer Agency

Vancouver, British Columbia, V5Z4E6, Canada

ACTIVE NOT RECRUITING

Nova Scotia Health Authority

Halifax, Nova Scotia, B3H 1V7, Canada

ACTIVE NOT RECRUITING

Juravinski Cancer Centre

Hamilton, Ontario, L8V5C2, Canada

ACTIVE NOT RECRUITING

Princess Margaret Cancer Centre University Health Network

Toronto, Ontario, M5G2M9, Canada

ACTIVE NOT RECRUITING

CIUSSS de l Est de l Ile de Montreal Installation Hopital Maisonneuve Rosemont

Montreal, Quebec, H1T 2M4, Canada

ACTIVE NOT RECRUITING

Saskatoon Cancer Centre

Saskatoon, Saskatchewan, S7N 4H4, Canada

ACTIVE NOT RECRUITING

Beijing Chaoyang Hospital

Beijing, 100020, China

ACTIVE NOT RECRUITING

Peking University First Hospital

Beijing, 100034, China

COMPLETED

Peking University People's Hospital

Beijing, 101199, China

ACTIVE NOT RECRUITING

The Second Xiangya Hospital of Central South Hospital

Changsha, 410011, China

ACTIVE NOT RECRUITING

Changzhou No 2 Peoples Hospital

Changzhou, 213000, China

ACTIVE NOT RECRUITING

Sichuan Provincial Peoples Hospital

Chengdu, 610032, China

COMPLETED

Fujian Meidical University Union Hospital

Fuzhou, 350001, China

COMPLETED

The First Affiliated Hospital of Fujian Medical University

Fuzhou, 350005, China

COMPLETED

Sun Yat Sen University Cancer Center

Guangzhou, 510060, China

ACTIVE NOT RECRUITING

Nanfang Hospital of Southern Medical Hospital

Guangzhou, 510515, China

COMPLETED

First hospital affiliated of Zhejiang Medical university

Hangzhou, 310003, China

ACTIVE NOT RECRUITING

The Second Affiliated Hospital of Zhejiang University College of Medicine

Hangzhou, 310009, China

COMPLETED

The Affiliated Hospital of Inner Mongolia Medical College

Hohhot, 010051, China

COMPLETED

Qilu Hospital of Shandong University

Jinan, 250012, China

COMPLETED

The First Affiliated Hospital of NanChang University

Nanchang, 330006, China

ACTIVE NOT RECRUITING

Nanjing Drum Tower Hospital

Nanjing, 210008, China

ACTIVE NOT RECRUITING

The First Affiliated Hospital of Guangxi Medical University

Nanning, 530021, China

COMPLETED

Ruijing Hospital Affiliated To Shanghai Jiaotong University School Of Medicine

Shanghai, 200025, China

ACTIVE NOT RECRUITING

Tongji Hospital of Tongji University

Shanghai, 200065, China

COMPLETED

Shanghai Fourth People s Hospital

Shanghai, 200434, China

ACTIVE NOT RECRUITING

Shengjing Hospital Of China Medical University

Shenyang, 110055, China

ACTIVE NOT RECRUITING

Peking University Shenzhen Hospital

Shenzhen, 518036, China

ACTIVE NOT RECRUITING

Shanxi Bethune Hospital

Taiyuan, 030032, China

COMPLETED

Tianjin Medical University Cancer Institute and Hospital

Tianjin, 30060, China

ACTIVE NOT RECRUITING

The First Affiliated Hospital of Wenzhou Medical University

Wenzhou, 325000, China

ACTIVE NOT RECRUITING

Tongji Hospital, Tongji Medical College of HUST

Wuhan, 430030, China

ACTIVE NOT RECRUITING

The Second Affiliated Hospital of Xi'an Jiaotong University

Xi'an, 710004, China

COMPLETED

The first affiliated hospital of xiamen university

Xiamen, 361026, China

COMPLETED

Fakultni nemocnice Brno

Brno-Bohunice, 625 00, Czechia

ACTIVE NOT RECRUITING

Fakultni nemocnice Hradec Kralove

Hradec Králové, 500 05, Czechia

ACTIVE NOT RECRUITING

University Hospital Olomouc

Olomouc, 779 00, Czechia

ACTIVE NOT RECRUITING

Fakultni Nemocnice Ostrava

Ostrava, 708 52, Czechia

ACTIVE NOT RECRUITING

Aarhus University Hospital

Aarhus, 8200, Denmark

COMPLETED

Odense University Hospital

Odense C, 5000, Denmark

ACTIVE NOT RECRUITING

Vejle Hospital

Vejle, 7100, Denmark

COMPLETED

Hopital Claude Huriez

Lille, 59000, France

ACTIVE NOT RECRUITING

CHU de Limoges Hopital Dupuytren

Limoges, 87042, France

COMPLETED

Hospices Civils de Lyon HCL

Lyon, 69002, France

ACTIVE NOT RECRUITING

Institut Paoli Calmettes

Marseille, 13009, France

ACTIVE NOT RECRUITING

CHU Nantes

Nantes, 44093, France

ACTIVE NOT RECRUITING

Hopital Saint Louis

Paris, 75010, France

ACTIVE NOT RECRUITING

CHU de Bordeaux - Hospital Haut-Leveque

Pessac, 33604, France

ACTIVE NOT RECRUITING

Institut de Cancerologie Strasbourg Europe ICANS

Strasbourg, 67200, France

COMPLETED

Institut Universitaire du Cancer Toulouse Oncopole

Toulouse, 31100, France

ACTIVE NOT RECRUITING

CHRU Tours Hopital Bretonneau

Tours, 37044, France

ACTIVE NOT RECRUITING

Klinikum Augsburg

Augsburg, 86156, Germany

ACTIVE NOT RECRUITING

Universitaetsklinikum Halle Saale

Halle, 06120, Germany

ACTIVE NOT RECRUITING

Universitaetsklinikum Heidelberg

Heidelberg, 69120, Germany

ACTIVE NOT RECRUITING

Universitaetsklinikum Magdeburg A.oe.R

Magdeburg, 39120, Germany

COMPLETED

Klinikum rechts der Isar der TU Muenchen

München, 81675, Germany

COMPLETED

Universitaetsklinikum Tuebingen

Tübingen, 72076, Germany

ACTIVE NOT RECRUITING

Universitaetsklinikum Wuerzburg

Würzburg, 97080, Germany

COMPLETED

251 Airforces Hospital

Athens, 115 25, Greece

ACTIVE NOT RECRUITING

Alexandra General Hospital of Athens

Athens, 115 28, Greece

ACTIVE NOT RECRUITING

Anticancer Hospital of Thessaloniki Theageneio

Thessaloniki, 546 39, Greece

ACTIVE NOT RECRUITING

Semmelweis Egyetem, Belgyogyaszati es Hematologiai Klinika

Budapest, 1088, Hungary

ACTIVE NOT RECRUITING

Del Pesti Centrumkorhaz Orszagos Hematologiai es Infektologiai Intezet Szent Laszlo Telephely

Budapest, 1097, Hungary

ACTIVE NOT RECRUITING

Debreceni Egyetem Klinikai Kozpont

Debrecen, 4032, Hungary

ACTIVE NOT RECRUITING

Szabolcs Szatmar Bereg Varmegyei Oktatokorhaz

Nyíregyháza, 4400, Hungary

ACTIVE NOT RECRUITING

Pecsi Tudomanyegyetem Klinikai Kozpont

Pécs, 7624, Hungary

ACTIVE NOT RECRUITING

Fortis Memorial Research Institute

Gūrgaon, 122002, India

ACTIVE NOT RECRUITING

Sanjay Gandhi Postgraduate Institute of Medical Sciences

Lucknow, 226014, India

COMPLETED

Deenanath Mangeshkar Hospital and Research Centre

Pune, 411004, India

ACTIVE NOT RECRUITING

Shamir Medical Center Assaf Harofeh

Be’er Ya‘aqov, 70300, Israel

ACTIVE NOT RECRUITING

Carmel Medical Center

Haifa, 3436212, Israel

ACTIVE NOT RECRUITING

Rabin Medical center - Petah-Tikva

Petah Tikva, 49100, Israel

ACTIVE NOT RECRUITING

Sheba Medical Center

Ramat Gan, 52621, Israel

ACTIVE NOT RECRUITING

Tel Aviv Sourasky Medical Center

Tel Aviv, 64239, Israel

ACTIVE NOT RECRUITING

Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo Alessandria

Alessandria, 15121, Italy

ACTIVE NOT RECRUITING

A O U Sant Orsola Malpighi

Bologna, 40138, Italy

ACTIVE NOT RECRUITING

oncologia medica - Oncology

Brindisi, 72100, Italy

ACTIVE NOT RECRUITING

ARNAS Garibaldi P O Nesima

Catania, 95122, Italy

ACTIVE NOT RECRUITING

Ospedale Policlinico San Martino IRCCS

Genova, 16132, Italy

ACTIVE NOT RECRUITING

Asst Ovest Milanese - Ospedale Di Legnano

Legnano, 20025, Italy

ACTIVE NOT RECRUITING

Fondazione IRCCS Ca Granda Ospedale Policlinico Di Milano

Milan, 20122, Italy

ACTIVE NOT RECRUITING

IRCCS Ospedale San Raffaele

Milan, 20132, Italy

ACTIVE NOT RECRUITING

Fondazione IRCCS Policlinico San Matteo

Pavia, 27100, Italy

ACTIVE NOT RECRUITING

Presidio Ospedaliero Pescara

Pescara, 65124, Italy

ACTIVE NOT RECRUITING

Ospedale S. Maria Delle Croci

Ravenna, 48121, Italy

ACTIVE NOT RECRUITING

Oncologia Medica-Città Della Salute E Della Scienza Di Torino

Torino, 10126, Italy

ACTIVE NOT RECRUITING

Azienda Ospedaliera Universitaria Integrata Verona

Verona, 37134, Italy

ACTIVE NOT RECRUITING

Juntendo University Hospital

Bunkyō City, 113 8431, Japan

ACTIVE NOT RECRUITING

Fukuoka University Hospital

Fukuoka, 814-0180, Japan

ACTIVE NOT RECRUITING

Hamamatsu University Hospital

Hamamatsu, 431 3192, Japan

ACTIVE NOT RECRUITING

Kanazawa University Hospital

Kanazawa, 920 8641, Japan

COMPLETED

University Hospital Kyoto Prefectural University of Medicine

Kyoto, 602-8566, Japan

ACTIVE NOT RECRUITING

National Hospital Organization Nagasaki Medical Center

Nagasaki, 856-8562, Japan

COMPLETED

Japanese Red Cross Narita Hospital

Narita, 286-8523, Japan

ACTIVE NOT RECRUITING

Niigata Cancer Center Hospital

Niigata, 951-8566, Japan

ACTIVE NOT RECRUITING

Hyogo Medical University Hospital

Nishinomiya Shi, 663 8501, Japan

ACTIVE NOT RECRUITING

Japanese Red Cross Osaka Hospital

Osaka, 543-8555, Japan

ACTIVE NOT RECRUITING

Sapporo City General Hospital

Sapporo, 060-8604, Japan

ACTIVE NOT RECRUITING

Tohoku University Hospital

Sendai, 980 8574, Japan

ACTIVE NOT RECRUITING

Japanese Red Cross Medical Center

Shibuya-ku, 150-8935, Japan

ACTIVE NOT RECRUITING

Iwate Medical University Hospital

Shiwa-gun, 028-3695, Japan

COMPLETED

The University of Osaka Hospital

Suita, 565 0871, Japan

COMPLETED

Shizuoka Cancer Center

Sunto Gun, 411 8777, Japan

ACTIVE NOT RECRUITING

The Cancer Institute Hospital of JFCR

Tokyo, 135 8550, Japan

ACTIVE NOT RECRUITING

Tottori University Hospital

Tottori, 683-0824, Japan

ACTIVE NOT RECRUITING

University of Tsukuba Hospital

Tsukuba, 305 8576, Japan

ACTIVE NOT RECRUITING

Kanagawa Cancer Center

Yokohama, 241 8515, Japan

ACTIVE NOT RECRUITING

Centro de Quimioterapia e Investigacion

Guadalajara, 45645, Mexico

ACTIVE NOT RECRUITING

Hematologica Alta Especialidad

Huixquilucan, 52787, Mexico

ACTIVE NOT RECRUITING

Hospital Universitario Dr Jose Eleuterio Gonzalez

Monterrey, 64460, Mexico

ACTIVE NOT RECRUITING

Flevoziekenhuis

Almere Stad, 1315RA, Netherlands

ACTIVE NOT RECRUITING

Catharinaziekenhuis

Eindhoven, 5623 EJ, Netherlands

ACTIVE NOT RECRUITING

St. Antonius Ziekenhuis Nieuwegein

Nieuwegein, 3435 CM, Netherlands

ACTIVE NOT RECRUITING

Haga ziekenhuis

The Hague, 2545 CH, Netherlands

ACTIVE NOT RECRUITING

Isala Kliniek

Zwolle, 8025 AB, Netherlands

ACTIVE NOT RECRUITING

Wojewodzki Szpital Specjalistyczny

Biała Podlaska, 21 500, Poland

ACTIVE NOT RECRUITING

Szpital Specjalistyczny w Brzozowie Podkarpacki Osrodek Onkologiczny im Ks B Markiewicza

Brzozów, 36-200, Poland

ACTIVE NOT RECRUITING

Swietokrzyskie Centrum Onkologii SPZOZ w Kielcach

Kielce, 25 734, Poland

ACTIVE NOT RECRUITING

Centrum Onkologii Ziemii Lubelskiej

Lublin, 20-090, Poland

ACTIVE NOT RECRUITING

Uniwersytecki Szpital Kliniczny Nr 1 PUM im prof Tadeusza Sokolowskiego w Szczecinie

Szczecin, 71-252, Poland

ACTIVE NOT RECRUITING

Uniwersytecki Szpital Kliniczny im Jana Mikulicza Radeckiego we Wroclawiu

Wroclaw, 50 367, Poland

ACTIVE NOT RECRUITING

King Abdullah International Medical Research Center (KAIMRC)

Riyadh, 11481, Saudi Arabia

COMPLETED

King Faisal Specialist Hospital & Research Center

Riyadh, 11564, Saudi Arabia

ACTIVE NOT RECRUITING

King Fahad Medical City

Riyadh, 12231, Saudi Arabia

COMPLETED

Dong-A University Hospital

Busan, 49201, South Korea

ACTIVE NOT RECRUITING

Pusan National University Hospital

Busan, 49241, South Korea

ACTIVE NOT RECRUITING

Chonnam National University Hwasun Hospital

Jeollanam-do, 58128, South Korea

COMPLETED

Seoul National University Hospital

Seoul, 03080, South Korea

ACTIVE NOT RECRUITING

Samsung Medical Center

Seoul, 06351, South Korea

ACTIVE NOT RECRUITING

The Catholic University of Korea Seoul St Mary s Hospital

Seoul, 06591, South Korea

ACTIVE NOT RECRUITING

Ulsan University Hospital

Ulsan, 44033, South Korea

ACTIVE NOT RECRUITING

Hosp. de Cabuenes

Asturias, 33394, Spain

ACTIVE NOT RECRUITING

Hosp Univ Vall D Hebron

Barcelona, 08035, Spain

ACTIVE NOT RECRUITING

Hosp. Univ. de Burgos

Burgos, 09003, Spain

ACTIVE NOT RECRUITING

Hosp. San Pedro de Alcantara

Cáceres, 10003, Spain

ACTIVE NOT RECRUITING

Hosp. Univ. Donostia

Donostia / San Sebastian, 20014, Spain

ACTIVE NOT RECRUITING

Hosp. Univ. Virgen de Las Nieves

Granada, 18014, Spain

ACTIVE NOT RECRUITING

Hosp. Univ. Lucus Augusti

Lugo, 27003, Spain

ACTIVE NOT RECRUITING

Hosp. Univ. La Paz

Madrid, 28046, Spain

ACTIVE NOT RECRUITING

Hosp. Univ. Son Espases

Palma de Mallorca, 07120, Spain

COMPLETED

Clinica Univ. de Navarra

Pamplona, 31008, Spain

ACTIVE NOT RECRUITING

Complejo Hosp de Navarra - Hosp de Navarra

Pamplona, 31008, Spain

ACTIVE NOT RECRUITING

Hosp Clinico Univ de Salamanca

Salamanca, 37007, Spain

COMPLETED

Hosp. Univ. Marques de Valdecilla

Santander, 39008, Spain

ACTIVE NOT RECRUITING

Hosp. Clinico Univ. de Santiago

Santiago de Compostela, 15706, Spain

ACTIVE NOT RECRUITING

Skanes universitetssjukhus

Lund, 221 85, Sweden

ACTIVE NOT RECRUITING

Norrlands Universitetssjukhus

Umeå, 901 85, Sweden

ACTIVE NOT RECRUITING

Akademiska Sjukhuset

Uppsala, 75185, Sweden

ACTIVE NOT RECRUITING

Varberg Hospital

Varberg, 432 81, Sweden

COMPLETED

Ankara Universitesi Tip Fakultesi Cebeci Arastirma ve Uygulama Hastanesi

Ankara, 06620, Turkey (Türkiye)

ACTIVE NOT RECRUITING

Liv Hospital Ankara

Ankara, 06680, Turkey (Türkiye)

ACTIVE NOT RECRUITING

Pamukkale Universitesi Tip Fakultesi

Denizli, 20070, Turkey (Türkiye)

ACTIVE NOT RECRUITING

Medipol University Hospital

Istanbul, 34214, Turkey (Türkiye)

ACTIVE NOT RECRUITING

Ondokuz Mayis Universitesi Saglik Uygulama ve Arastirma Merkezi

Samsun, 55200, Turkey (Türkiye)

ACTIVE NOT RECRUITING

Blackpool Victoria Hospital

Blackpool, FY3 8NR, United Kingdom

COMPLETED

University Hospital of Wales

Cardiff, CF14 4HY, United Kingdom

ACTIVE NOT RECRUITING

Ninewells Hospital

Dundee, DD1 9SY, United Kingdom

ACTIVE NOT RECRUITING

St James University Hospital

Leeds, LS9 7TF, United Kingdom

ACTIVE NOT RECRUITING

Kings College Hospital

London, SE5 9RS, United Kingdom

ACTIVE NOT RECRUITING

Nottingham City Hospital

Nottingham, NG5 1PB, United Kingdom

ACTIVE NOT RECRUITING

University Hospitals Plymouth NHS Trust

Plymouth, PL6 8DH, United Kingdom

ACTIVE NOT RECRUITING

Queen Alexandra Hospital

Portsmouth, PO6 3LY, United Kingdom

ACTIVE NOT RECRUITING

MeSH Terms

Conditions

Multiple Myeloma

Interventions

talquetamabpomalidomideelotuzumabDexamethasoneBortezomib

Condition Hierarchy (Ancestors)

Neoplasms, Plasma CellNeoplasms by Histologic TypeNeoplasmsHemostatic DisordersVascular DiseasesCardiovascular DiseasesParaproteinemiasBlood Protein DisordersHematologic DiseasesHemic and Lymphatic DiseasesHemorrhagic DisordersLymphoproliferative DisordersImmunoproliferative DisordersImmune System Diseases

Intervention Hierarchy (Ancestors)

PregnadienetriolsPregnadienesPregnanesSteroidsFused-Ring CompoundsPolycyclic CompoundsSteroids, FluorinatedBoronic AcidsAcids, NoncarboxylicAcidsInorganic ChemicalsBoron CompoundsOrganic ChemicalsPyrazinesHeterocyclic Compounds, 1-RingHeterocyclic Compounds

Study Officials

  • Janssen Research & Development, LLC Clinical Trial

    Janssen Research & Development, LLC

    STUDY DIRECTOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
phase 3
Allocation
RANDOMIZED
Masking
NONE
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 5, 2024

First Posted

January 17, 2024

Study Start

January 22, 2024

Primary Completion

April 23, 2026

Study Completion (Estimated)

March 31, 2028

Last Updated

March 13, 2026

Record last verified: 2026-03

Data Sharing

IPD Sharing
Will share

The data sharing policy of Johnson \& Johnson Innovative Medicine is available at www.innovativemedicine.jnj.com/our-innovation/clinical-trials/transparency. As noted on this site, requests for access to the study data can be submitted through Yale Open Data Access (YODA) Project site at yoda.yale.edu.

More information

Locations