Investigating the Effects of Krill Oil and Krill Protein on Post-exercise Muscle Protein Metabolism

NCT05774444 | Completed DMC

• 1 other identifier: KIPLING
• Study Type: interventional
• Target: 52
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of the current study is to find out if krill oil can increase muscle building processes in response to resistance (weightlifting) type exercise. Others aim are to determine the effects of krill protein, and the interaction of krill oil and protein, on muscle building processes in response to resistance (weightlifting) type exercise.

Conditions

Hypertrophy

Keywords

Omega-3; Krill oil; Protein; Exercise

Outcome Measures

Primary Outcomes (1)

• Post-exercise muscle protein synthesis

  Muscle protein synthesis measured 3-7h after a single bout of resistance exercise

  3-7 hours

Secondary Outcomes (10)

• Change in Muscle thickness

  Change from baseline to 8 weeks

• Change in grip strength

  Change from baseline to 8 weeks

• Change in fat mass

  Change from baseline to 8 weeks

• Change in lean mass

  Change from baseline to 8 weeks

• Change in muscle strength

  Change from baseline to 8 weeks

Study Arms (4)

Vegetable oil + Carbohydrate

PLACEBO COMPARATOR

The vegetable oil will be a placebo control for the Krill oil (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g)

Dietary Supplement: Vegetable oil; Dietary Supplement: Carbohydrate

Vegetable oil + Krill protein

EXPERIMENTAL

The vegetable oil will be a placebo control for the Krill oil (4g/day). Krill protein will be our active intervention (20g)

Dietary Supplement: Krill protein; Dietary Supplement: Vegetable oil

Krill oil + Carbohydrate

EXPERIMENTAL

The Krill oil will be the active supplement for the intervention (4g/day). The carbohydrate will be a placebo control for the Krill protein (20g)

Dietary Supplement: Krill oil; Dietary Supplement: Carbohydrate

Krill oil + Krill protein

EXPERIMENTAL

Both the Krill oil (4g/day) and the Krill protein will be the active intervention supplements (20g)

Dietary Supplement: Krill oil; Dietary Supplement: Krill protein

Interventions

Krill oil DIETARY_SUPPLEMENT

Krill oil will be supplemented to see if they can gain strength and/or muscle mass following supplementation.

Krill oil + Carbohydrate; Krill oil + Krill protein

Krill protein DIETARY_SUPPLEMENT

Krill protein will be given to the participant following a resistance exercise bout.

Krill oil + Krill protein; Vegetable oil + Krill protein

Vegetable oil DIETARY_SUPPLEMENT

This will be the control against the Krill oil

Vegetable oil + Carbohydrate; Vegetable oil + Krill protein

Carbohydrate DIETARY_SUPPLEMENT

This will be the control for the Krill protein

Krill oil + Carbohydrate; Vegetable oil + Carbohydrate

Eligibility Criteria

• Age: 60 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Be 60 years old or older
• Have a BMI of less than 35kg/m2
• Be participating in structured exercise for less than 2h per week

You may not qualify if:

• Diabetes
• Severe cardiovascular disease
• Seizure disorders,
• Uncontrolled hypertension (\>150/90mmHg at baseline measurement)
• Cancer or cancer that has been in remission \<5 years
• Ambulatory impairments which would limit ability to perform assessments of muscle function
• Dementia
• Taking medication known to affect muscle (e.g., steroids)
• Have an implanted electronic device (e.g., pacemaker/defibrillator/insulin pump),
• Anticoagulant therapy
• Allergies to seafood
• Regular consumption of more than 1 portion of oily fish per week.

Sponsors & Collaborators

• University of Glasgow: lead
• Aker BioMarine: collaborator

Study Sites (1)

Stuart Robert Gray

Glasgow, United Kingdom

Location

MeSH Terms

Conditions

Hypertrophy; Motor Activity

Interventions

krill protein extract; Plant Oils; Carbohydrates

Condition Hierarchy (Ancestors)

Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Oils; Lipids; Plant Preparations; Biological Products; Complex Mixtures

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: All supplements with be colour and flavour matched
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Parallel 2x2 factorial design

Study Record Dates

• First Submitted: March 7, 2023
• First Posted: March 17, 2023
• Study Start: May 1, 2023
• Primary Completion: May 25, 2025
• Study Completion: May 25, 2025
• Last Updated: April 29, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)