Middle Age muScle Krill Study

NCT06005064 | Completed

• 1 other identifier: MASK
• Study Type: interventional
• Target: 54
• Locations: 1 country
• Sites: 1

Brief Summary

This study will determine the effect of 6 months of supplementation with krill oil on muscle strength and mass in middle-aged adults. The study hypothesis is that krill oil supplementation will increase muscle strength and mass in middle-aged adults.

Conditions

Sarcopenia

Keywords

Krill oil; Muscle strength; Muscle mass; Middle-aged

Outcome Measures

Primary Outcomes (1)

• Change in knee extensor maximal isometric torque ( MVC)

  Knee extensor maximal isometric torque measured during a maximal voluntary contraction

  Change from baseline to 24 weeks

Secondary Outcomes (5)

• Change in fat mass

  Change from baseline to 24 weeks

• Change in lean mass

  Change from baseline to 24 weeks

• Change in omega-3 levels

  Change from baseline to 24 weeks

• Change in Grip strength

  Change from baseline to 24 weeks

• Change in Muscle thickness

  Change from baseline to 24 weeks

Other Outcomes (3)

• Change in systemic inflammation

  Change from baseline to 24 weeks

• Change in muscle inflammation

  Change from baseline to 24 weeks

• Change in muscle anabolic signalling

  Change from baseline to 24 weeks

Study Arms (2)

Intervention

EXPERIMENTAL

Krill oil 4g/day for 24 weeks

Dietary Supplement: Krill oil

Placebo

PLACEBO COMPARATOR

Vegetable oil 4g/day for 24 weeks

Dietary Supplement: Vegetable oil

Interventions

Krill oil DIETARY_SUPPLEMENT

Superba krill oil

Intervention

Vegetable oil DIETARY_SUPPLEMENT

Mixed vegetable oil

Placebo

Eligibility Criteria

• Age: 35 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Be 35-60 years old
• Have a BMI of less than 35kg/m2

You may not qualify if:

• People with diabetes, severe cardiovascular disease, seizure disorders, uncontrolled hypertension (\>150/90mmHg at baseline measurement), cancer or cancer that has been in remission \<5 years, ambulatory impairments which would limit the ability to perform assessments of muscle function, dementia, on anticoagulant therapy, and/or taking medication known to affect muscle (e.g., steroids).
• People who have allergies to seafood, and/or regular consumption of more than 1 portion of oily fish per week.
• People who perform regular (\>1 day/week) resistance exercise training.

Sponsors & Collaborators

• University of Glasgow: lead

Study Sites (1)

University of Glasgow

Glasgow, United Kingdom

Location

MeSH Terms

Conditions

Sarcopenia

Interventions

Plant Oils

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Oils; Lipids; Plant Preparations; Biological Products; Complex Mixtures

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: Supplements will be identical in look and taste
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: 1:1 basis

Study Record Dates

• First Submitted: August 16, 2023
• First Posted: August 22, 2023
• Study Start: November 1, 2023
• Primary Completion: October 1, 2025
• Study Completion: October 1, 2025
• Last Updated: April 29, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)