Antioxidant Vitaminas and Hypertrophy Adaptations to Resistance Training

NCT04828642 | Completed

• 1 other identifier: CIPI/20/209
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This investigations aims to investigate whether supplementation with antioxidant vitamins (vitamin C and vitamin E) can influence, enhancing or blocking, the hypertrophic adaptations caused by strength training in sedentary subjects.

Conditions

Hypertrophy

Outcome Measures

Primary Outcomes (25)

• DEXA

  Evaluation of muscle mass with dual energy X-ray absorptiometry

  Week 0

• DEXA

  Evaluation of muscle mass with dual energy X-ray absorptiometry

  Week 10

• Anthropometry

  Evaluation of muscle mass by a ISAK 1 level anthropometrist

  Week 0

• Anthropometry

  Evaluation of muscle mass by a ISAK 1 level anthropometrist

  Week 5

• Anthropometry

  Evaluation of muscle mass by a ISAK 1 level anthropometrist

  Week 10

• Bioimpedance

  Evaluation of muscle mass with an Inbody

  Week 0

• Bioimpedance

  Evaluation of muscle mass with an Inbody

  Week 5

• Bioimpedance

  Evaluation of muscle mass with an Inbody

  Week10

• DOMS

  Delayed onset muscle soreness evaluated with visual analoguic scale (0 no pain- 10 maximal pain)

  Week 0

• DOMS

  Delayed onset muscle soreness evaluated with visual analoguic scale (0 no pain- 10 maximal pain)

  Week 5

• DOMS

  Delayed onset muscle soreness evaluated with visual analoguic scale (0 no pain- 10 maximal pain)

  Week 10

• Manual dinamometry

  Handgrip

  Week 0

• Manual dinamometry

  Handgrip

  Week 5

• Leg dinamometry

  Dinamometer

  Week 0

• Leg dinamometry

  Dinamometer

  Week 5

• Leg dinamometry

  Dinamometer

  Week 10

• RPE

  10-point scale (no exertion 0- maximal effort 10)

  Week 0

• RPE

  10-point scale (no exertion 0- maximal effort 10)

  Week 5

• RPE

  10-point scale (no exertion 0- maximal effort 10)

  Week 10

• 1 RM

  Bench press and squats

  Week 0

• 1 RM

  Bench press and squats

  Week 5

• 1 RM

  Bench press and squats

  Week 10

• Parameters determined by ENCODER

  Bench press and squats

  Week 0

• Parameters determined by ENCODER

  Bench press and squats

  Week 5

• Parameters determined by ENCODER

  Bench press and squats

  Week 10

Study Arms (2)

Supplementation group

ACTIVE COMPARATOR

Antioxidant vitamins (Vitamin C (1000 mg) + Vitamine E (235 mg))

Dietary Supplement: Vitamin C and vitamin E

Placebo group

PLACEBO COMPARATOR

Placebo supplementation with the same aspect as supplementation

Dietary Supplement: Placebo

Interventions

Vitamin C and vitamin E DIETARY_SUPPLEMENT

1000 mg 235 mg

Also known as: Ascorbic acid and tocopherol

Supplementation group

Placebo DIETARY_SUPPLEMENT

Placebo

Placebo group

Eligibility Criteria

• Age: 18 Years - 30 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Experience in strength training of at least one year

You may not qualify if:

• Smokers
• Antioxidant supplementation
• Injuries or diseases

Sponsors & Collaborators

• Universidad Europea de Madrid: lead

Study Sites (1)

Universidad Europea de Madrid

Madrid, 28011, Spain

Location

Related Publications (2)

• Dutra MT, Martins WR, Ribeiro ALA, Bottaro M. The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis. J Sports Med (Hindawi Publ Corp). 2020 Jan 8;2020:3505209. doi: 10.1155/2020/3505209. eCollection 2020.

  PMID: 31970196 BACKGROUND

• Dutra MT, Alex S, Mota MR, Sales NB, Brown LE, Bottaro M. Effect of strength training combined with antioxidant supplementation on muscular performance. Appl Physiol Nutr Metab. 2018 Aug;43(8):775-781. doi: 10.1139/apnm-2017-0866. Epub 2018 Jun 25.

  PMID: 29939770 RESULT

MeSH Terms

Conditions

Hypertrophy

Interventions

Ascorbic Acid; Vitamin E; Tocopherols

Condition Hierarchy (Ancestors)

Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Sugar Acids; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Hydroxy Acids; Carbohydrates; Benzopyrans; Pyrans; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: The provider will produce the supplementation and the placebo with the same aspect, marked with numbers
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: predoctoral researcher

Model Details: A randomized, double-blind, placebo-control, parallel controlled trial will be conducted.

Study Record Dates

• First Submitted: March 11, 2021
• First Posted: April 2, 2021
• Study Start: February 1, 2021
• Primary Completion: April 15, 2021
• Study Completion: June 30, 2021
• Last Updated: August 3, 2021

Record last verified: 2021-08

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)