Mycoprotein, Resistance Training, and Hypertrophy

NCT03572127 | Completed

• 1 other identifier: 1718/27
• Study Type: interventional
• Target: 42
• Locations: 1 country
• Sites: 1

Brief Summary

Protein is vital for the preservation of health and optimal adaptation to training. However, animal proteins come with economic and environmental issues. The study will investigate the effect of non-animal vs animal based habitual protein consumption on muscle protein metabolism and changes in muscle mass and function over a longer period of time.

Conditions

Hypertrophy

Keywords

Protein; Resistance Exercise; Skeletal Muscle; Mycoprotein; Sustainability

Outcome Measures

Primary Outcomes (1)

• Muscle Protein Synthesis

  Muscle protein synthesis measured via deuterium oxide

  3 days

Secondary Outcomes (3)

• Muscle fiber CSA

  10 weeks

• Muscle Strength

  10 weeks

• Muscle CSA

  10 weeks

Study Arms (2)

Non-animal derived diet

EXPERIMENTAL

High protein diet derived from non-animal sources.

Other: Diet

Animal derived diet

ACTIVE COMPARATOR

High protein diet derived from animal sources.

Other: Diet

Interventions

Diet OTHER

High protein diet derived from either animal or non-animal sources.

Animal derived diet; Non-animal derived diet

Eligibility Criteria

• Age: 18 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Males and females 18 - 40 years of age.
• Body mass index between 18 and 30.
• Recreationally active.
• Resistance training experienced (have previous performed resistance exercise, and are familiar with the basic movements).

You may not qualify if:

• Any diagnosed metabolic impairment (e.g. type 1 or 2 Diabetes) (as this may affect normal protein metabolism).
• Any diagnosed cardiovascular disease or hypertension (to avoid any complications associated with heavy exercise).
• Elevated blood pressure at the time of screening. (An average systolic blood pressure reading of ≥140mmHg over two or more measurements and an average diastolic blood pressure of ≥90mmHg over two or more measurements.)
• Chronic use of any prescribed or over the counter pharmaceuticals (that may modulate muscle protein metabolism).
• A personal or family history of epilepsy, seizures or schizophrenia.
• Allergic to mycoprotein / Quorn, penicillin, or milk.
• Pregnancy.

Sponsors & Collaborators

• University of Exeter: lead
• Quorn: collaborator

Study Sites (1)

University of Exeter, Sports & Health Sciences, College of Life & Environmental Sciences

Exeter, Devon, EX1 2LU, United Kingdom

Location

Related Publications (1)

• Monteyne AJ, Coelho MOC, Murton AJ, Abdelrahman DR, Blackwell JR, Koscien CP, Knapp KM, Fulford J, Finnigan TJA, Dirks ML, Stephens FB, Wall BT. Vegan and Omnivorous High Protein Diets Support Comparable Daily Myofibrillar Protein Synthesis Rates and Skeletal Muscle Hypertrophy in Young Adults. J Nutr. 2023 Jun;153(6):1680-1695. doi: 10.1016/j.tjnut.2023.02.023. Epub 2023 Feb 22.

  PMID: 36822394 DERIVED

MeSH Terms

Conditions

Hypertrophy

Interventions

Diet

Condition Hierarchy (Ancestors)

Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Nutritional Physiological Phenomena; Diet, Food, and Nutrition; Physiological Phenomena

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: One group will consume a non-animal derived high protein diet, whilst the other group will consume a more traditional animal protein based diet.

Study Record Dates

• First Submitted: May 21, 2018
• First Posted: June 28, 2018
• Study Start: May 16, 2018
• Primary Completion: March 1, 2020
• Study Completion: May 1, 2022
• Last Updated: April 27, 2025

Record last verified: 2025-04

Locations

GB (1)