The Krill Ageing Muscle Mechanisms (KAMM) Study

NCT06296875 | Recruiting

• 1 other identifier: KAMM
• Study Type: interventional
• Target: 80
• Locations: 1 country
• Sites: 1

Brief Summary

This study aims to determine the mechanisms via which krill oil supplementation increases muscle strength and whether this translates to improvements in gait and functional characteristics in older adults. The studies we will carry out will establish, in healthy older adults, the effects of 6 months of supplementation with krill oil Objective 1) Muscle structure and function Hypothesis: Krill oil supplementation will increase muscle size and strength alongside positive changes in muscle architecture (pennation angle and fascicle length). Objective 2) Neuromuscular control and central nervous system (CNS) function Hypothesis: Krill oil supplementation will improve Neuromuscular Junction (NMJ) transmission stability and increase central drive and intramuscular coherence, as a measure of muscle synergy. Objective 3) Gait and functional characteristics Hypothesis: Krill oil supplementation will improve gait and functional characteristics.

Conditions

Sarcopenia

Keywords

Krill oil; Muscle Strength; Neuromuscular function; Physical function

Outcome Measures

Primary Outcomes (3)

• Grip strength

  We will measure grip strength using a handgrip dynamometer, making 3 maximal contractions in each hand, with the dominant hand recorded. The highest grip strength will be used in analysis.

  Change from baseline to 24 weeks

• Neuromuscular junction transmission instability

  We will assess peripheral motor unit (MU) characteristics in the vastus lateralis muscle using intramuscular electromyography

  Change from baseline to 24 weeks

• Gait speed

  We will measure gait speed using a gaitrite connected mat during a 4 m walk test and the timed up and go test at usual speed.

  Change from baseline to 24 weeks

Secondary Outcomes (16)

• Knee extensor maximal torque

  Change from baseline to 24 weeks

• Vastus lateralis muscle cross sectional area

  Change from baseline to 24 weeks

• Vastus lateralis pennation angle

  Change from baseline to 24 weeks

• Vastus lateralis fascicle length

  Change from baseline to 24 weeks

• Erythrocyte fatty acid composition

  Change from baseline to 24 weeks

Study Arms (2)

Vegetable oil

PLACEBO COMPARATOR

4g/day vegetable oil for 24 weeks

Dietary Supplement: Vegetable oil

Krill oil

ACTIVE COMPARATOR

4/g/day krill oil for 24 weeks

Dietary Supplement: Krill oil

Interventions

Vegetable oil DIETARY_SUPPLEMENT

mixed vegetable oil

Vegetable oil

Krill oil DIETARY_SUPPLEMENT

Krill oil

Also known as: (SuperbaBoost)

Krill oil

Eligibility Criteria

• Age: 65 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Older Adult (65+)

You may qualify if:

• body mass index (BMI) \</= 30 kg/m2
• Age \>/= 65 years
• Capacity to consent
• Living within the Glasgow area

You may not qualify if:

• Diabetes mellitus
• Severe cardiovascular disease
• Seizure disorders
• Uncontrolled hypertension (\>150/90mmHg)
• Active cancer or cancer that has been in remission \<5 years
• Participation in any resistance exercise training within the last 6 months
• Impairments which may limit ability to perform assessments of muscle function
• Dementia
• Fish/shellfish allergy
• Taking medication known to affect muscle (e.g. steroids, Selective serotonin reuptake inhibitors) or anticoagulants (e.g. warfarin)
• Taking omega-3 supplements in the last 3 months
• Regularly consuming 1 or more portions of oily fish per week
• Not able to understand English

Sponsors & Collaborators

• University of Glasgow: lead

Study Sites (1)

University of Glasgow

Glasgow, United Kingdom

RECRUITING

MeSH Terms

Conditions

Sarcopenia

Interventions

Plant Oils

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Oils; Lipids; Plant Preparations; Biological Products; Complex Mixtures

Central Study Contacts

Stuart Gray

CONTACT

+441413302569; stuart.gray@glasgow.ac.uk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: All supplements will be matched for taste and look
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor of Muscle and Metabolic Health

Model Details: 1:1 parallel group design

Study Record Dates

• First Submitted: February 29, 2024
• First Posted: March 6, 2024
• Study Start: September 1, 2024
• Primary Completion (Estimated): August 1, 2026
• Study Completion (Estimated): August 1, 2026
• Last Updated: May 1, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)