Krill Oil and Resistance Exercise in Older Adults

NCT05869513 | Completed

• 1 other identifier: KOREA
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The aim of this study is to determine whether krill oil supplementation enhances effects of a pragmatic resistance exercise programme on adaptations in muscle strength, mass, function and neuromuscular function in sedentary older adults. Hypothesis - krill oil supplementation will enhance the beneficial effects of resistance exercise on muscle strength, function, mass and neuromuscular function in sedentary older adults.

Conditions

Sarcopenia

Keywords

Home exercise; Resistance exercise; Exercise; Krill oil; Muscle strength; Neuromuscular function; Physical function

Outcome Measures

Primary Outcomes (1)

• Nueromuscular Junction (NMJ) transmission instability

  NMJ transmission instability will be measured by iEMG

  Change from baseline to 16 weeks

Secondary Outcomes (7)

• Knee extensor maximal torque

  Change from baseline to 8 16 weeks

• 30s chair stand test

  Change from baseline to 16 weeks

• Gait speed

  Change from baseline to 16 weeks

• Force steadiness during submaximal isometric knee extensor contractions

  Change from baseline to 16 weeks

• Red Blood Cell Omega-3 levels

  Change from baseline to 16 weeks

Other Outcomes (20)

• Step Time (sec)

  Change from baseline to 16 weeks

• Cycle Time (sec)

  Change from baseline to 16 weeks

• Step Length (cm)

  Change from baseline to16 weeks

Study Arms (2)

Vegetable oil + Resistance exercise

PLACEBO COMPARATOR

4g/day vegetable oil and home based resistance exercise for 16 weeks

Dietary Supplement: Vegetable oil; Other: Home-based resistance exercise

Krill oil + Resistance exercise

ACTIVE COMPARATOR

4g/day krill oil and home based resistance exercise for 16 weeks

Dietary Supplement: Krill oil; Other: Home-based resistance exercise

Interventions

Vegetable oil DIETARY_SUPPLEMENT

Mixed vegetable oil

Vegetable oil + Resistance exercise

Krill oil DIETARY_SUPPLEMENT

Superba Krill Oil

Krill oil + Resistance exercise

Home-based resistance exercise OTHER

Home based resistance band and body weight exercise

Krill oil + Resistance exercise; Vegetable oil + Resistance exercise

Eligibility Criteria

• Age: 60 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Over the age of 60 years
• scoring a low level of physical activity based on international physical activity questionnaire (not meeting the recommend physical activity which is at least 600 MET-min per week).

You may not qualify if:

• Diabetes
• severe cardiovascular disease
• seizure disorders
• uncontrolled hypertension (\>150/90mmHg at baseline measurement)
• cancer or cancer that has been in remission \<5 years
• ambulatory impairments which would limit ability to perform assessments of muscle function
• dementia
• taking medication known to affect muscle (e.g. steroids)
• have an implanted electronic device (e.g. pacemaker/defibrillator/insulin pump)
• on anticoagulant therapy
• allergies to seafood
• regular consumption of more than 1 portion of oily fish per week
• already taking fish or krill oil or other n3 PUFA supplements
• femoral neck fracture or other severe of hip or knee operations
• stroke

Sponsors & Collaborators

• University of Glasgow: lead

Study Sites (1)

University of Glasgow

Glasgow, United Kingdom

Location

MeSH Terms

Conditions

Sarcopenia; Motor Activity

Interventions

Plant Oils

Condition Hierarchy (Ancestors)

Muscular Atrophy; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Atrophy; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Behavior

Intervention Hierarchy (Ancestors)

Oils; Lipids; Plant Preparations; Biological Products; Complex Mixtures

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: TRIPLE
• Who Masked: PARTICIPANT, INVESTIGATOR, OUTCOMES ASSESSOR
• Masking Details: All supplements will be matched for taste and look
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: 1:1 parallel group design

Study Record Dates

• First Submitted: May 11, 2023
• First Posted: May 22, 2023
• Study Start: May 5, 2023
• Primary Completion: February 1, 2024
• Study Completion: February 1, 2024
• Last Updated: March 30, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

GB (1)